Therapeutic nanosweepers promote β-amyloid removal from the brain for Alzheimer's disease treatment

Xu, Huaibao; Zhao, Yu; Qi, Yilin; Xue, Xue; Liu, Yang

doi:10.1039/d2bm01319c

Biomater. Sci.

2022

DOI: 10.1039/d2bm01319c

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Therapeutic nanosweepers promote β-amyloid removal from the brain for Alzheimer's disease treatment

Huaibao Xu

Yu Zhao

Yilin Qi

et al.

Abstract: Neurotoxic β-amyloid (Aβ) deposits are generally believed as the crucial pathogenic event in Alzheimer’s disease (AD). However, current Aβ-targeting medicines show limited therapeutic efficacy due to ineffective Aβ removal and...

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2023

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Cited by 4 publications

References 55 publications

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Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Huang,

Liao,

et al. 2023

Adv Funct Materials

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Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that constitutes the third most common cause of death among elderly individuals. AD patients suffer from behavioral problems regularly, like memory loss, thinking deficits, and cognitive disorders. Currently, the incidence rate of AD has been on the rise worldwide. Therefore, it is imperative to develop effective strategies for the treatment and prevention of AD. The inherent characteristics of low‐dimensional nanomaterials, primarily their smaller size and surface structure, make them well‐suited for fulfilling the essential requirements of therapeutic drug design. Consequently, these nanomaterials offer a highly appealing and alternative approach to treating AD. Here, the low‐dimensional nanomaterials used in the treatment of AD to provide new ideas, methods, and comprehensive perspectives for the management of AD are reviewed. This review will advance the comprehensive understanding of the potential of low‐dimensional nanomaterials in the field of neuro medicine, which also will have a positive impact on future research.

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Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Huang,

Liao,

et al. 2023

Adv Funct Materials

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Self‐Destructive Nanoscavengers Capture and Clear Neurotoxic Soluble β‐Amyloid Aggregates

Huang

Liu

2023

Macromol. Rapid Commun.

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Cerebral soluble β‐amyloid aggregates (sAβs) accumulation is one of the most important causes in Alzheimer's disease (AD) progression. In order to mitigate the neurotoxicity induced by sAβs and achieve enhanced AD therapeutic outcomes, robust sAβs clearance become an emerging task. Herein, we report a self‐destructive nanoscavenger (SDNS) based on multifunctional peptide‐polymer complexes that can capture extracellular sAβs via hydrogen‐bonding interactions and deliver them into microglial lysosomes. The internalized SDNS then occurs self‐destruction within lysosomes and upregulates autophagy, thereby promoting the degradation of neurotoxic sAβs. Importantly, the enhanced autophagy also significantly suppresses the secretion of inflammatory factors by microglia, which is induced by internalized sAβs. Given that cerebral persistent inflammatory environment disturbs microglia‐mediated phagocytosis and degradation, we believe that this synergistic approach has valuable potential as a therapeutic strategy for AD.This article is protected by copyright. All rights reserved

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ROS-responsive nanomodulators downregulate IFITM3 expression and eliminate ROS for Alzheimer’s disease combination treatment

Liu

2023

Journal of Colloid and Interface Science

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Therapeutic nanosweepers promote β-amyloid removal from the brain for Alzheimer's disease treatment

Abstract: Neurotoxic β-amyloid (Aβ) deposits are generally believed as the crucial pathogenic event in Alzheimer’s disease (AD). However, current Aβ-targeting medicines show limited therapeutic efficacy due to ineffective Aβ removal and...

Cited by 4 publications

References 55 publications

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

Self‐Destructive Nanoscavengers Capture and Clear Neurotoxic Soluble β‐Amyloid Aggregates

ROS-responsive nanomodulators downregulate IFITM3 expression and eliminate ROS for Alzheimer’s disease combination treatment

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