Abstract:Cerebral soluble β‐amyloid aggregates (sAβs) accumulation is one of the most important causes in Alzheimer's disease (AD) progression. In order to mitigate the neurotoxicity induced by sAβs and achieve enhanced AD therapeutic outcomes, robust sAβs clearance become an emerging task. Herein, we report a self‐destructive nanoscavenger (SDNS) based on multifunctional peptide‐polymer complexes that can capture extracellular sAβs via hydrogen‐bonding interactions and deliver them into microglial lysosomes. The inter… Show more
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