Therapeutic modality of plasmacytoid dendritic cells in a murine model of &lt;em&gt;Aspergillus fumigatus&lt;/em&gt; sensitized and infected asthma

Matsuse, Hiroto; Yamagishi, Tohru; Kodaka, Norio; Nakano, Chihiro; Obase, Yasushi; Mukae, Hiroshi

doi:10.3934/allergy.2017.4.232

Cited by 2 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, IL-17, but not IL-6, had a positive correlation with ED visits and had a significant mediation effect on the association between Candida albicans sensitization and ED visit. A previous study found that IL-17 increased in Aspergillus fumigatus -sensitized mice [ 29 ]. In addition, IL-17A response is associated strongly with acute ABPA, and its specific decline in response to ABPA treatment suggests that this atypical Th17 response plays an active role in manifesting and/or exacerbating disease [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Mediating Effect of Cytokines on the Association between Fungal Sensitization and Poor Clinical Outcome in Asthma

Lin

Kor

et al. 2022

Biomedicines

View full text Add to dashboard Cite

Sensitization to fungal allergens is one of the proposed phenotypes in asthma. An association between fungal sensitization and worse clinical outcomes is apparent. Moreover, fungal sensitization in asthma that is associated with different type of immunological mechanism has been reported. How the role of cytokines mediates the association between fungal sensitization and poorer asthmatic outcomes remains unclear. We aimed to determine role of cytokines in the relationship between fungal sensitization and worse clinical outcomes in asthma. Method: We conducted a prospective study to recruit adult patients with asthma. Data including age, sex, height, weight, smoking history, medication, emergency visit and admission, pulmonary function testing result, and Asthma Control Test (ACT) scores were collected. We used the automated BioIC method to measure fungal allergen sIgE in sera. Serum levels of Interleukin (IL) -4, IL-13, IL-6, IL-9, IL-10, IL-17 A, IL-22, Interferon (IFN) -γ, Immunoglobulin E (IgE), Tumor necrosis factor-α (TNF-α), and Transforming growth factor-β (TGF-β) were measured using ELISA. Result: IL-6 and IL-17A had a significant positive correlation between sensitization and most fungi species compared to IgE. Sensitization to Candida albicans had strongly positive association both with IL-6 and IL-17A. However, only IL-17A had significant relationship with ED visit times. The mediation analysis result indicates that IL-17A had a significant positively mediating effect (ME) on the association between Candida albicans and ED visit times. Conclusion: IL-17A is a potential mediator to link Candida albicans sensitization and ED visits for asthma. We suggest that patients with fungal sensitization, such as Candida albicans, have poorer outcomes associated with Th17-mediated immune response rather than Th2.

show abstract

Section: Discussionmentioning

confidence: 99%

The Mediating Effect of Cytokines on the Association between Fungal Sensitization and Poor Clinical Outcome in Asthma

Lin

Kor

et al. 2022

Biomedicines

View full text Add to dashboard Cite

show abstract

“…On the observations in HDM- and OVA-induced asthma models, pDCs have been reported to dampen allergic inflammation (utilising depletion and cell transfer strategies) [ 98 – 100 ]. In the context of fungi, transfer of pDCs from Af sensitised mice successfully suppressed allergic inflammation via IL-10 secretion in recipient mice [ 101 ]. Furthermore, pDCs can mediate Treg generation leading to dampening of airway hyperreactivity [ 102 ].…”

Section: Introductionmentioning

confidence: 99%

Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells

Furlong-Silva

Cook

2022

PLoS Pathog

View full text Add to dashboard Cite

Fungi are abundant in the environment, causing our lungs to be constantly exposed to a diverse range of species. While the majority of these are cleared effectively in healthy individuals, constant exposure to spores (especially Aspergillus spp.) can lead to the development of allergic inflammation that underpins and worsen diseases such as asthma. Despite this, the precise mechanisms that underpin the development of fungal allergic disease are poorly understood. Innate immune cells, such as macrophages (MΦs) and dendritic cells (DCs), have been shown to be critical for mediating allergic inflammation to a range of different allergens. This review will focus on the crucial role of MΦ and DCs in mediating antifungal immunity, evaluating how these immune cells mediate allergic inflammation within the context of the lung environment. Ultimately, we aim to highlight important future research questions that will lead to novel therapeutic strategies for fungal allergic diseases.

show abstract

Therapeutic modality of plasmacytoid dendritic cells in a murine model of <em>Aspergillus fumigatus</em> sensitized and infected asthma

Cited by 2 publications

References 31 publications

The Mediating Effect of Cytokines on the Association between Fungal Sensitization and Poor Clinical Outcome in Asthma

The Mediating Effect of Cytokines on the Association between Fungal Sensitization and Poor Clinical Outcome in Asthma

Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells

Contact Info

Product

Resources

About