The Mediating Effect of Cytokines on the Association between Fungal Sensitization and Poor Clinical Outcome in Asthma

Lin, Ching-Hsiung; Li, Yirong; Kor, Chew‐Teng; Lin, Sheng‐Hao; Ji, Bin‐Chuan; Lin, Ming-Tai; Chai, Woei-Horng

doi:10.3390/biomedicines10061452

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Recent studies documented the association between fungal sensitization and asthmatic severity. Lin et al reported that the connection between fungal sensitization and poorer clinical findings is evident [21]. While Kao et al added that fungal sensitization not only contributes to the development of asthma but also the severity of asthmatic condition [22].…”

Section: Discussionmentioning

confidence: 99%

Association between severity of asthma and fungal sensitization in severely asthmatic patients

Eldeen

Elkolaly

Sharshar

et al. 2023

Microbes and Infectious Diseases

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Background: Fungal sensitization is usually associated with increased asthmatic severity, morbidity and mortality, including higher rates of hospital and intensive care admission. However, the possible association between fungal airway colonization with regard to sensitization remains controversial. Objectives: to investigate the presence of severe asthma with fungal sensitization among asthmatic patients and to find evidence of Aspergillus fumigatus (A. fumigatus) role in severely asthmatic patients. Methods: this study investigated forty asthmatic patients and twenty controls. Demographic data of all subjects within the study was collected, as well as total serum IgE, A.fumigatus specific IgE and A. fumigatus galactomannan antigen ELISA test. Results: our results showed significant elevation of total IgE, Aspergillus specific IgE and A. fumigatus galactomannan antigen in 75% of severely asthmatic patients, compared to patients with mild asthma and negative values in control. Conclusion:We report a high percent of A. fumigatus colonization among severely asthmatic patients. This supports the hypothesis of the role of fungal elements colonization in the airways of patients with severe asthma.

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Section: Discussionmentioning

confidence: 99%

Association between severity of asthma and fungal sensitization in severely asthmatic patients

Eldeen

Elkolaly

Sharshar

et al. 2023

Microbes and Infectious Diseases

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“…Exposure to different environmental factors may affect different mechanisms and asthma progression. For example, IL-17A is a potential mediator to link Candida albicans sensitization and poor outcomes for asthma [ 127 ].…”

Section: Biomarkers Of Asthmamentioning

confidence: 99%

Current Understanding of Asthma Pathogenesis and Biomarkers

Habib

Pasha

Tang

2022

Cells

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Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect the cellular and molecular mechanisms of asthma. Aberrant T helper type 2 (Th2) inflammation is the most important pathological process for asthma, which is mediated by Th2 cytokines, such as interleukin (IL)-5, IL-4, and IL-13. Approximately 50% of mild-to-moderate asthma and a large portion of severe asthma is induced by Th2-dependent inflammation. Th2-low asthma can be mediated by non-Th2 cytokines, including IL-17 and tumor necrosis factor-α. There is emerging evidence to demonstrate that inflammation-independent processes also contribute to asthma pathogenesis. Protein kinases, adapter protein, microRNAs, ORMDL3, and gasdermin B are newly identified molecules that drive asthma progression, independent of inflammation. Eosinophils, IgE, fractional exhaled nitric oxide, and periostin are practical biomarkers for Th2-high asthma. Sputum neutrophils are easily used to diagnose Th2-low asthma. Despite progress, more studies are needed to delineate complex endotypes of asthma and to identify new and practical biomarkers for better diagnosis, classification, and treatment.

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