Therapeutic management in cardiac lymphoma

Yoshihara, Mari; Itamura, Hidekazu; Fukushima, Noriyasu; Itoh, Masatoshi; Furukawa, Kojiro; Nagashima, Daisuke; Kamachi, Kazuharu; Kitamura, Hiroaki; Shindo, Takero; Kubota, Yasushi; Sueoka, Eisaburo; Morita, Shigeki; Ichinohe, Tatsuo; Kimura, Shinya

doi:10.3109/10428194.2013.828355

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…This regimen gradually decreased the size of the tumour (figure 1A2, B2), and the patient became stable without any symptoms 15 months after the first admission. This case was previously reported in a case series, ‘Therapeutic management in cardiac lymphoma’, which focused on the management of lymphoma 1. Therefore, we newly report this case, focusing on the importance of cardiac management.…”

Section: Case Presentationmentioning

confidence: 73%

Successful treatment of primary cardiac lymphoma causing ST-elevation myocardial infarction by percutaneous coronary intervention combined with chemotherapy

et al. 2014

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SUMMARYA 76-year-old immunocompetent woman presented to our hospital with general fatigue. Her blood pressure was 60/40 mm Hg and pulse rate was 110 bpm. An electrocardiogram showed ST-elevation in the II, III and aVF leads with complete atrioventricular block. An echocardiogram and CT revealed pericardial effusion and a 6 cm solid tumour lying anterior to the heart. The right coronary artery (RCA) ran through the centre of the tumour, which bulged into the right atrium for 35 mm and vibrated. Emergent coronary angiography revealed 99% stenosis with delay at the proximal RCA; however, intravascular ultrasound showed no atheromatous changes, and the RCA was compressed by the extravascular mass. Successful coronary stenting improved the coronary flow. The following day, a biopsy was performed via thoracotomy without any events, the results of which showed diffuse-type large B-cell lymphoma histologically. Chemotherapy gradually reduced the tumour size, and the patient became stable haemodynamically. BACKGROUND

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Section: Case Presentationmentioning

confidence: 73%

Successful treatment of primary cardiac lymphoma causing ST-elevation myocardial infarction by percutaneous coronary intervention combined with chemotherapy

et al. 2014

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“…In most cases of secondary cardiac lymphoma, symptoms are attributed to heart failure or rhythm alterations [14], which is similar to our case. While there are no established guidelines for the management of cardiac lymphoma, treatment approaches for cardiac lymphoma involve chemotherapy, often combined with radiotherapy, surgery, autologous hematopoietic stem cell transplantation, and chimeric antigen receptor (CAR) T-cell therapy [15,16]. Unfortunately, in our case of secondary cardiac lymphoma, autologous hematopoietic stem cell transplantation and CAR T-cell therapy were not considered due to the patient's age and overall general condition.…”

Section: Discussionmentioning

confidence: 99%

Chromosomal Translocations t(1; 22)(q21; q11.2) and t(6; 18)(p25; q21) in a Patient with Diffuse Large B-cell Lymphoma: FISH Analysis

Kitamura,

Kubota,

Hanamura

et al. 2023

Preprint

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Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and a heterogeneous disease characterized by mature B-cell neoplasms. The standard immunochemotherapy for DLBCL is R-CHOP, which includes rituximab, cyclophosphamide, doxoru-bicin, vincristine, and prednisone. Up to 30-40% of patients with DLBCL either exhibit primary refractory disease to standard treatment or experience relapse after the initial response. A 72-year-old man diagnosed with DLBCL involving chromosomal translocations t(1;22)(q21;q11.2) and t(6;18)(p25;q21) showed primary refractory disease after the fourth cycle of R-CHOP. The patient ultimately experienced cardiac involvement by the lymphoma and received salvage chemotherapy. He passed away about 15 months away after the diagnosis of DLBCL. We conducted fluorescence in situ hybridization (FISH) for further analysis of the chromosomal translocations. The breakpoint of chromosome 1q21 was located at a distance of around 151 Mb from the telomeric end of chromosome 1p. The breakpoint in chromosome 22q11 contains the immunoglobulin lambda locus. Furthermore, the breakpoint of chromosome 6p was in the telomeric region of chromosome 6p21. The breakpoint of chromosome 18q21 contains BCL2. This case report presents the first documented co-occurrence of chromosomal translocations t(1;22)(q21;q11.2) and t(6;18)(p25;q21) in a patient with DLBCL. These chromosomal translocations may indicate a worse clinical outcome.

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“…Anthracycline and cyclophosphamide are key therapies for DLBCL [2]. To date, it seems clear that the introduction of a rituximab containing regimen has led to improvement in the overall survival (OS) of patients with PCL [3]; however the optimum schedule of chemotherapy in PCL has not been determined [4]. …”

Section: Discussionmentioning

confidence: 99%

Primary cardiac lymphoma with isolated parenchymal central nervous system relapse: report of two cases and review of the literature

Montoro

Mattia

Bertazzoni

et al. 2014

ecancer

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Primary cardiac lymphoma (PCL) is a rare subset of non-Hodgkin’s lymphoma involving the heart and/or pericardium with no or minimal evidence of extracardiac involvement at presentation. Distant relapses have infrequently been observed.We report two cases of this disorder that showed isolated central nervous system (CNS) relapse. Diagnosis by endomyocardial biopsy was consistent with diffuse large B-cell lymphoma. After immunochemotherapy they achieved complete remission (CR). Eight and five weeks after, isolated CNS relapses were observed respectively. The first patient was treated with high-dose methotrexate (HD-MTX) and high-dose cytarabine, resulting in a second CR. She then went onto receive autologous stem-cell transplantation but unfortunately died shortly after because of infection. The second patient received systemic CNS prophylaxis with HD-MTX, and later she was treated with an induction chemotherapy strategy with evidencing of progressive disease after two courses of treatment. She was subsequently initiated on a salvage therapy with cytarabine, followed by whole-brain radiotherapy, and autologous stem-cell transplant (ASCT), finally achieving a complete remission.Isolated CNS relapse is a very uncommon pattern in PCL and a standard approach to treatment is not yet well established. Nevertheless, the importance of CNS evaluation, using magnetic resonance imaging (MRI) and lumbar puncture, in patients with PCL should be considered, and further studies are recommended to determine the appropriate management of this complication.

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Therapeutic management in cardiac lymphoma

Cited by 5 publications

References 13 publications

Successful treatment of primary cardiac lymphoma causing ST-elevation myocardial infarction by percutaneous coronary intervention combined with chemotherapy

Successful treatment of primary cardiac lymphoma causing ST-elevation myocardial infarction by percutaneous coronary intervention combined with chemotherapy

Chromosomal Translocations t(1; 22)(q21; q11.2) and t(6; 18)(p25; q21) in a Patient with Diffuse Large B-cell Lymphoma: FISH Analysis

Primary cardiac lymphoma with isolated parenchymal central nervous system relapse: report of two cases and review of the literature

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