Therapeutic Implications of microRNAs in Depressive Disorders: A Review

Abstract

MicroRNAs are hidden players in complex psychophysical phenomena such as depression and anxiety related disorders though the activation and deactivation of multiple proteins in signaling cascades. Depression is classified as a mood disorder and described as feelings of sadness, loss, or anger that interfere with a person’s everyday activities. In this review, we have focused on exploration of the significant role of miRNAs in depression by affecting associated target proteins (cellular and synaptic) and their signaling pathways which can be controlled by the attachment of miRNAs at transcriptional and translational levels. Moreover, miRNAs have potential role as biomarkers and may help to cure depression through involvement and interactions with multiple pharmacological and physiological therapies. Taken together, miRNAs might be considered as promising novel therapy targets themselves and may interfere with currently available antidepressant treatments.

Human Gut Microbiota for Diagnosis and Treatment of Depression

“…Emerging data demonstrate that miRNA activity may play an important role in long-term changes related to the pathogenesis and treatment of depression [ 90 ]. miRNAs have already been recommended as pharmacological targets and biomarkers for the treatment and diagnosis of depression and anxiety [ 98 ].…”

Is it possible to develop a vaccine against depression based on microRNA?

“…Hassan et al 23 's research demonstrates the critical role miRNAs play in innate and adaptive immune responses, controlling the growth, activation, survival, and proliferation of T and B cells. Acute inflammatory responses and pathogen recognition are significantly regulated by miRNAs, including miR-155, miR-146, and miR-223.…”

MicroRNAs as Potential Biomarkers of Mental Disorders: Diagnostic and Prognostic Implications

“…В последние годы чрезвычайно активно изучалась роль микроРНК в оценке психических функций человека. Основные усилия были сконцентрированы в области изучения когнитивного функционирования [30][31][32][33], а также исследования механизмов обучения и памяти [34], эмоциональных расстройств [20,35,36] и психологического стресса [13][14][15]37].…”

“…Нельзя не упомянуть и о потенциальных терапевтических возможностях использования микроРНК при психических заболеваниях. Такие попытки предпринимаются, в частности, в отношении депрессивного расстройства [53], биполярного расстройства [54], расстройств аутистического спектра [55], резистентной к терапии эпилепсии [56].…”