Therapeutic hypothermia after cardiac arrest

Hypothermia After Cardiac Arrest as a Novel Approach to Increase Survival in Cardiopulmonary Cerebral Resuscitation: A Review

“…Initial studies on patients with cardiac arrest at the early stages of CPCR have shown that the use of thrombolytic agents may increase life expectancy and improve neurological outcome ( 7 , 39 ). Since hypothermia affects the number of platelets, function of platelets and coagulation cascade, which causes slight increase in susceptibility to bleeding, the anticoagulant effect of hypothermia may have a protective effect on the central nervous and cardiac systems ( 8 , 32 , 44 ).…”

Hypothermia After Cardiac Arrest as a Novel Approach to Increase Survival in Cardiopulmonary Cerebral Resuscitation: A Review

“…Initial studies on patients with cardiac arrest at the early stages of CPCR have shown that the use of thrombolytic agents may increase life expectancy and improve neurological outcome ( 7 , 39 ). Since hypothermia affects the number of platelets, function of platelets and coagulation cascade, which causes slight increase in susceptibility to bleeding, the anticoagulant effect of hypothermia may have a protective effect on the central nervous and cardiac systems ( 8 , 32 , 44 ).…”

The effects of mild induced hypothermia on the myocardium: a systematic review

“…Firstly, a failure of perfusion caused by global hypoperfusion, with or without coronary artery stenosis or occlusion, leads to ischaemia of the myocardium and resultant ischaemic damage [1,[19][20][21]. Secondly, reperfusion of the ischaemic tissue, occurring when an adequate perfusion pressure is restored or when coronary revascularisation occurs, leads to reperfusion and re-oxygenation injury [25].…”

“…These harmful effects are reversible with rewarming. Most patients who have a cardiac arrest do not survive, and full neurological recovery occurs in only 6-23% [1]. In order to improve survival and reduce such neurological injury, guidelines have recently been published describing the post-cardiac arrest bundle of care: this includes early coronary reperfusion if appropriate (primary angioplasty or thrombolysis), haemodynamic optimisation, and control of ventilation, blood glucose, temperature and seizures [2,3].…”

Overview and future prospects of out-of-hospital cardiac arrest registries in Japan

“…Consequently, most data regarding OHCA were derived exclusively from either pre- or in-hospital registries. 37 , 38 , 39 , 40 , 41 Without an integrated registry, it was challenging to comprehensively assess resuscitation strategies including those at the scene and in hospital. To address this limitation, it was necessary to develop a registry with comprehensive data that could provide insights into factors changing over time and those associated with improved outcomes.…”

Hypothermia After Cardiac Arrest as a Novel Approach to Increase Survival in Cardiopulmonary Cerebral Resuscitation: A Review

“…Initial studies on patients with cardiac arrest at the early stages of CPCR have shown that the use of thrombolytic agents may increase life expectancy and improve neurological outcome ( 7 , 39 ). Since hypothermia affects the number of platelets, function of platelets and coagulation cascade, which causes slight increase in susceptibility to bleeding, the anticoagulant effect of hypothermia may have a protective effect on the central nervous and cardiac systems ( 8 , 32 , 44 ).…”

The effects of mild induced hypothermia on the myocardium: a systematic review

“…Firstly, a failure of perfusion caused by global hypoperfusion, with or without coronary artery stenosis or occlusion, leads to ischaemia of the myocardium and resultant ischaemic damage [1,[19][20][21]. Secondly, reperfusion of the ischaemic tissue, occurring when an adequate perfusion pressure is restored or when coronary revascularisation occurs, leads to reperfusion and re-oxygenation injury [25].…”

“…These harmful effects are reversible with rewarming. Most patients who have a cardiac arrest do not survive, and full neurological recovery occurs in only 6-23% [1]. In order to improve survival and reduce such neurological injury, guidelines have recently been published describing the post-cardiac arrest bundle of care: this includes early coronary reperfusion if appropriate (primary angioplasty or thrombolysis), haemodynamic optimisation, and control of ventilation, blood glucose, temperature and seizures [2,3].…”

Overview and future prospects of out-of-hospital cardiac arrest registries in Japan

“…Consequently, most data regarding OHCA were derived exclusively from either pre- or in-hospital registries. 37 , 38 , 39 , 40 , 41 Without an integrated registry, it was challenging to comprehensively assess resuscitation strategies including those at the scene and in hospital. To address this limitation, it was necessary to develop a registry with comprehensive data that could provide insights into factors changing over time and those associated with improved outcomes.…”

Hypothermia After Cardiac Arrest as a Novel Approach to Increase Survival in Cardiopulmonary Cerebral Resuscitation: A Review

“…Initial studies on patients with cardiac arrest at the early stages of CPCR have shown that the use of thrombolytic agents may increase life expectancy and improve neurological outcome ( 7 , 39 ). Since hypothermia affects the number of platelets, function of platelets and coagulation cascade, which causes slight increase in susceptibility to bleeding, the anticoagulant effect of hypothermia may have a protective effect on the central nervous and cardiac systems ( 8 , 32 , 44 ).…”

The effects of mild induced hypothermia on the myocardium: a systematic review

“…Firstly, a failure of perfusion caused by global hypoperfusion, with or without coronary artery stenosis or occlusion, leads to ischaemia of the myocardium and resultant ischaemic damage [1,[19][20][21]. Secondly, reperfusion of the ischaemic tissue, occurring when an adequate perfusion pressure is restored or when coronary revascularisation occurs, leads to reperfusion and re-oxygenation injury [25].…”

“…These harmful effects are reversible with rewarming. Most patients who have a cardiac arrest do not survive, and full neurological recovery occurs in only 6-23% [1]. In order to improve survival and reduce such neurological injury, guidelines have recently been published describing the post-cardiac arrest bundle of care: this includes early coronary reperfusion if appropriate (primary angioplasty or thrombolysis), haemodynamic optimisation, and control of ventilation, blood glucose, temperature and seizures [2,3].…”

Overview and future prospects of out-of-hospital cardiac arrest registries in Japan

“…Consequently, most data regarding OHCA were derived exclusively from either pre- or in-hospital registries. 37 , 38 , 39 , 40 , 41 Without an integrated registry, it was challenging to comprehensively assess resuscitation strategies including those at the scene and in hospital. To address this limitation, it was necessary to develop a registry with comprehensive data that could provide insights into factors changing over time and those associated with improved outcomes.…”