Therapeutic Hypothermia After Cardiac Arrest

Nolan, Jerry P.; Morley, Peter; Hoek, Terry L. Vanden; Hickey, Robert W.; Kloeck, Walter; Billi, John E.; Böttiger, Bernd W.; Okada, Kazuhiro; Reyes, Carlo; Shüster, Michael; Steen, Petter Andreas; Weil, Max Harry; Wenzel, Volker; Carli, Pierre; Atkins, Dianne L.

doi:10.1161/01.cir.0000079019.02601.90

Cited by 792 publications

(207 citation statements)

References 41 publications

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“…Cardiac arrest and post-resuscitation period is associated with cellular necrosis due to hypoxia during the no-flow period, but substantial cellular damage also occurs after circulation has been restored [1,15,16], as a consequence of reperfusion injury and inflammatory response. Harmful processes that occur during the post-resuscitation period have in the past years been targeted with mild therapeutic hypothermia (MTH) which was proven to reduce mortality [17] and was adopted as a recommended treatment in such patients [18].…”

Section: Introductionmentioning

confidence: 99%

“…In the later paper [19], DNA was also quantified 24 hours and 72 hours after arrest, but no significant difference associated with hospital mortality was found. Respecting the facts that significant cellular damage may occur during the post-arrest period [1], and that that damage might be reduced by MTH [18], we investigated the prognostic value of cell free DNA at ICU admission and 24 hours after admission.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission

et al. 2014

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“…2,3 Therapeutic hypothermia (TH) has been shown to improve both survival and neurological outcomes after cardiac arrest in several clinical trials, and has been endorsed as an evidencebased treatment modality by the International Liaison Committee on Resuscitation. [4][5][6][7] Currently TH is applied in the post-resuscitation time period, to minimize reperfusion injury following ischemia and improve neurological outcome after ROSC is achieved. 8 Earlier animal work by our group and others has suggested that intra-arrest hypothermia may provide additional survival benefit compared to TH after resuscitation.…”

Section: Introductionmentioning

confidence: 99%

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

Zhao¹,

Abella²,

Beiser³

et al. 2008

Resuscitation

103

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SummaryBackground-Therapeutic hypothermia (TH) represents an important method to attenuate postresuscitation injury after cardiac arrest. Laboratory investigations have suggested that induction of hypothermia before return of spontaneous circulation (ROSC) may confer the greatest benefit. We hypothesized that a short delay in resuscitation to induce hypothermia before ROSC, even at the expense of more prolonged ischemia, may yield both physiological and survival advantages.

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“…It must be considered for all patients in whom there is indication for active treatment. This is regardless of the heart rate at the moment of the CA (IIa indication of the ILCOR for CA post ventricular fi brillation occurred in out-of-hospital environment and indication IIb for CA at any rhythm, and any place) whenever there is no contraindication 22 (Table 2). 19,23 .…”

Section: Temperaturementioning

confidence: 99%

Abordagem do paciente reanimado, pós-parada cardiorrespiratória

Pereira¹

2008

Rev. bras. ter. intensiva

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SUMMARY BACKGROUND AND OBJECTIVES:Out-of-hospital cardiac arrest is a major cause of death with survival rates as low as 5% to 35%. A large number of patients who survive resuscitation will face significant neurological damage, as a result of the ischemia that occurs both during cardiac arrest and reperfusion. However understanding of the mechanisms responsible for brain damage has not resulted in prognostic improvement. Therapeutic hypothermia after resuscitation may be a valid option associated to reduction of neurological damage. The purpose of this study was to review scientific evidence related to a therapy for patients resuscitated from cardiac arrest. CONTENTS: Description and analysis of the main risk factors associated with neurological damage after resuscitation from cardiac arrest as well as prognostic criteria was carried out. A non-systematic search was conducted in the PubMed data base for papers on a therapeutic approach for patients resuscitated from cardiac arrest. Bibliographic references of reviewed papers were also analyzed. Practical rules were drafted for such an approach.

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Therapeutic Hypothermia After Cardiac Arrest

Cited by 792 publications

References 41 publications

Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission

Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

Abordagem do paciente reanimado, pós-parada cardiorrespiratória

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