Therapeutic Evaluation of Unani Formulation in Dyslipidaemia:a Randomized Controlled Study

Abstract

Dyslipidaemia is a leading medical problem affecting overall health status of an individual. Deranged levels of lipid profile are responsible for atherosclerosis which ultimately leads to development of vascular diseases. If left untreated, it may result in various life threatening complications. Objective was to compare and evaluate the efficacy of test drug Qurs-e-Luk with control drug "Lipotab" in the management of Dyslipidaemia. It was a single blind, randomized, controlled, clinical trial. Thirty subjects of dyslipidaemia were selected and randomly assigned to test (20 patients) and control group (10 patients). Qurs-e-Luk and Lipotab were given to test and control groups in the form of powder (5 gm twice a day) and tablet (2 tablets per day) respectively for 60 days. All the patients of both groups were assessed on subjective and objective parameters at the baseline and after completion of trial, and the study outcome was analyzed using appropriate statistical tests. The test drug showed significant effect on few subjective and objective parameters in comparison to control drug without any significant side effects or toxicity. In test group, improvement in palpitation, fatigue and reduction in S. triglycerides and LDL was statistically significant (p < 0.05). The study infers that the comparative analyses of both drugs was not statistically significant; although improvement in subjective parameters was noted in both groups, and the effect on objective parameters was observed only in test group.

Dyslipidemia and its concept in Unani medicine: A review

“…They can also balance the Akhlat (Humors), such as Badyan (Foeniculm vulgare) [37] , Bikh Ajmod (Apium graveolens) [38] , Gudmar Booti (Gymnema sylvestre) [39] , Halela (Terminalia chebula) [40,41] , Lehsun (Allium sativum) [42,43] , Kaloonji (Nigella Sativa) [42] , Luk Maghsul (Laccifer lacca) [43] , Methi (Trigonella foenum-graecum) [44] , Sandrus (Trachelobium hornemanianum), Saad kofi (Cyperus rotundus), Soya (Anethum sowa) [45] , Sumbuluttib (Valeriana officinalis), Tukhme Karafs (Apium graveolens) [46] and Tukhme Suddab (Ruta graveolens) [47] Kasni (Cichorium intybus) [47] , Maku (Solanum nigrum) [48] , Afsanteen (Artemisia absinthium) [49] , Muquil (Commiphora mukul) [50] , Chhal Arjun (Terminalia arjuna) [51] , Badranjboya (Mellisa officinalis) [52] , Abresham (Bombyx mori) [53] , which have been reported as having antihyperlipidemic activity. Various Unani formulation have been used by physicians, based on their clinical experiences, to manage dyslipidemia and Farbahi such as Safoof Kalonji [54] , Habbe Sundarus [35] , Qurs Luk [55] , Itriphal Sagheer [56] , Majoon Sheer Alvi Khan [57] and Safoof Muhazzil [58,59] . [60] are the same as those stated by Sina [11] , Rushd [11] , and Nafis [16] (deranged cold temperament).…”