Therapeutic evaluation of the oral retinoid Ro 10-9359 in several non-psoriatic dermatoses

Viglioglia, P A

doi:10.1111/j.1365-2133.1980.tb01662.x

Cited by 36 publications

(21 citation statements)

References 9 publications

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“…An example of the beneficial effect of etretinate is shown in figure 2. Good results have also been report ed by Dinet et al [13], Viglioglia [14], and by Atherton and Wells [15], who performed a double-blind trial of maintenance therapy.…”

Section: Lamellar Ichthyosessupporting

confidence: 50%

“…A good result of oral retinoid therapy has been reported by Viglioglia [14] in 1 o f 2 pa tients affected with epidermal nevus. No response was observed in the second case, but it is not clear which type of epidermal nevus has been treated.…”

Section: Systematized Verrucous Lipidermal Nevimentioning

confidence: 92%

“…In this type o f hereditary palm oplantar keratosis, a good response is obtained with oral retinoid treatment [14,31], Before start ing the treatment, however, a biopsy should be performed in order to rule out the possi bility that the disease represents epidermolytic hyperkeratosis of Vorncr's type. This is even more important because the UnnaThost type seems to be much less frequent than the Vomer type of palm oplantar keralodcrma [29].…”

Section: Palmoplantar Kerutoderma O F the Unna-thost Typementioning

confidence: 99%

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Retinoids in Disorders of Keratinization: Their Use in Adults

Happle

Kerkhof²,

Traupe³

1987

Dermatology

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Hereditary disorders of keratinization may be a considerable handicap. Oral treatment with retinoids has been shown to be effective in many of these diseases. In the group of ichthyoses, the best results can be obtained in the various types of nonbullous congenital ichthyosis (erythrodermic autosomal recessive lamellar ichthyosis, nonerythrodermic autosomal recessive lamellar ichthyosis, autosomal dominant lamellar ichthyosis). It should be borne in mind, however, that retinoid therapy alone cannot lead to a complete response of these forms of ichthyosis and that this treatment cannot replace an appropriate topical treatment. During continuous treatment with etretinate a reduction of the dosis to 0.5 mg/kg is often necessary. Etretinate treatment of bullous congenital ichthyosiform erythroderma is more difficult, and it is advisable to begin with a low dosis of 0.25–0.5 mg/kg. The epidermolytic form of palmoplantar keratoderma is in our opinion no indication for retinoid treatment which seems to result inevitably in large erosions. Good or excellent results have been seen in other forms of palmoplantar keratoderma including mal de Meleda, Papillon-Lefèvre syndrome, erythrokeratodermia variabilis, verrucous epidermal nevi, Darier disease and pityriasis rubra pilaris. In patients with Darier disease it is wise to begin with a relatively low dosage of 0.5 mg/kg and to adjust the dosage to the further course of the disease. The same is true for the ichthyosis seen in the Netherton syndrome, which may be either a diffuse hyperkeratosis or ichthyosis linearis circumflexa. In view of the fact that any inherited keratinization disorder requires long-term treatment, the risk of bone toxicity should be carefully weighed against the benefit of this therapy. The results so far obtained indicate that the effect of etretin is comparable to that of etretinate in the treatment of inherited keratinization disorders. Intermittent therapy should be tried whenever possible. A combination therapy seems reasonable in pityriasis rubra pilaris of the adult type. We have seen good results by combination with PUVA treatment. Autosomal dominant ichthyosis vulgaris and X-linked recessive ichthyosis are inappropriate to treat with oral retinoid therapy because these diseases are too mild. Papillomatous epidermal nevi should also be excluded because they do not respond to the drug. Hailey-Hailey disease may even be worsened by this treatment. According to our experience, oral retinoid therapy has no effect in monilethrix.

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Section: Lamellar Ichthyosessupporting

confidence: 50%

Section: Systematized Verrucous Lipidermal Nevimentioning

confidence: 92%

Section: Palmoplantar Kerutoderma O F the Unna-thost Typementioning

confidence: 99%

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Retinoids in Disorders of Keratinization: Their Use in Adults

Happle

Kerkhof²,

Traupe³

1987

Dermatology

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“…Another similar keratinization disorderPapillon-Lefèvre syndrome -was reported to have normal [13][14][15] or depressed [16] PHA response in the patients or to have de pressed PHA, ConA, PWM response in both the patients and the unaffected members [17]. The HLA antigen distribution for our Mai de Meleda families will be a require ment for further studies on any existing genoimmunological specificity.…”

Section: Discussionmentioning

confidence: 99%

Report of a Family with Mal de Meleda in Taiwan: a Clinical, Histopathological and Immunological Study

Jee

Lee

et al. 1985

Dermatology

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A family in Taiwan is reported to have Mai de Meleda with possibly autosomal recessive inheritance among 5 of its members. The glove- and sock-like erythrokeratosis and the hyperkeratotic plaques of the knees and elbows are the common features. Erythema of the nose, cheeks, and the perioral area in 4 affected members, actinic elastosis in 2 severely affected members, and partially impaired cell-mediated immunity in vitro in both affected and unaffected members are notable findings. Tigason (etretinate) treatment was beneficial in regard to hyperkeratinization, but not to erythema.

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“…Two small groups of patients with "chronic" cutaneous LP 15 Oral Isotretinoin and Tretinoin. Oral isotretinoin, 0.5 mg/kg per day, was effective in 2 cases of severe LP with both cutaneous and oral lesions, 21 but we could not find a controlled study using this drug.…”

mentioning

confidence: 99%

Treatment of Lichen Planus

Cribier

Françès²,

Chosidow³

1998

Arch Dermatol

172

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To critically appraise the body of literature concerning treatment of lichen planus (LP).Design: Review of MEDLINE and BIOSIS databases to identify articles published with at least an English abstract before March 1998 that examined treatment of LP.Main Outcome Measures: Forming a primary database on which most recommendations are based. We thus selected 83 clinical trials or small series of patients in the medical literature that referenced clinical data on patients treated for LP.Results: There are no large randomized trials with definitive results in the medical literature examining the efficacy of the various drugs or physical treatments of LP. There are only 3 level B trials (small randomized trials with uncertain results because of moderate to high ␣ or ␤ error) that address efficacy of treatment in LP, ie, 1 with acitretin in cu-

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Therapeutic evaluation of the oral retinoid Ro 10-9359 in several non-psoriatic dermatoses

Cited by 36 publications

References 9 publications

Retinoids in Disorders of Keratinization: Their Use in Adults

Retinoids in Disorders of Keratinization: Their Use in Adults

Report of a Family with Mal de Meleda in Taiwan: a Clinical, Histopathological and Immunological Study

Treatment of Lichen Planus

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