Therapeutic Evaluation of Intralesional 5% 5‐Fluorouracil in Condyloma Acuminata

Pall, Anuj; Mahajan, Bharat Bhushan; Puri, Karanjit Pal Singh; Gupta, Rajesh Rani

doi:10.1111/j.1346-8138.2004.tb00678.x

Cited by 5 publications

(5 citation statements)

References 47 publications

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“…17 The intralesional 5-FU + LE injection was also used for the treatment of genital warts, and the results were 45%-75% complete response in the treatment of patients or lesions. 16,29,30 A previous study found easier and better response rates in common warts than palmoplantar warts. 9 On the other hand, another study reported better responses in palmoplantar warts than common and periungual warts.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the efficacy of intralesional5‐fluorouracil/lidocaine/epinephrine injection with cryotherapy to treat common and palmoplantar warts: A randomized, controlled trial

Sepaskhah

Sarani

Bagheri

2022

Dermatologic Therapy

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Cutaneous warts are treated by different treatments with various efficacy. Intralesional injection of 5-fluorouracil (IL 5-FU) has been compared with placebo and a few other wart treatments. Our objective was to compare the efficacy of IL 5-FU injection with cryotherapy to treat common and palmoplantar warts. Forty-five patients with common and palmoplantar warts were treated with either IL 5-FU admixed with lidocaine and epinephrine (5-FU + LE) or cryotherapy, once weekly for six sessions. The patients were assessed for clinical response score, the thickness of warts, pain score, and quality of life in treatment sessions, 2 and 8 weeks after the last session. Nine patients (64.3%) in the 5-FU + LE group, and five patients (35.7%) in cryotherapy group experienced complete response (p = 0.285). Both treatments caused improvement of clinical response score in the patients during the treatment time (p < 0.001), but the efficacy of treatments was not significantly different (p = 0.793).Changes in wart thickness were significantly more marked in the 5-FU + LE group compared to the cryotherapy group (p = 0.021). The patients in the cryotherapy group experienced more severe pain compared to the 5-FU + LE group (p = 0.011).The quality of life better improved in the 5-FU + LE group compared to the cryotherapy group (p = 0.02). To conclude, most of the patients that experienced complete clinical response had received 5-FU + LE injection, though the difference was not significant. However, 5-FU + LE injection accompanied less pain and caused more reduction in wart thickness and more improvement in quality of life compared to the cryotherapy.

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Section: Discussionmentioning

confidence: 99%

“…The intralesional 5‐FU + LE injection was also used for the treatment of genital warts, and the results were 45%–75% complete response in the treatment of patients or lesions 16,29,30 …”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of intralesional5‐fluorouracil/lidocaine/epinephrine injection with cryotherapy to treat common and palmoplantar warts: A randomized, controlled trial

Sepaskhah

Sarani

Bagheri

2022

Dermatologic Therapy

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“…Nanosystems can also be loaded onto a muco-adhesive in-situ gelling vehicle. The intimate interface between the mucus and gel enables transfer of the nanosystems to the site of action on the vaginal mucosa 78 .…”

Section: Designing a Cervico-vaginal Drug Delivery Systemmentioning

confidence: 99%

The Development of Locoregional Therapies as a Strategy for Reducing Cervical Cancer Mortality in Low to Middle Income Countries.

Chituku

Jones

Phillips

2022

Preprint

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Early detection concomitant with appropriate treatment intervention for pre-invasive cervical cancer has proved effective in the ‘war on cervical cancer’ in the developed world. Unfortunately, these advances have not been mirrored in the developing world, where incidence and mortality rates are currently approximately 90% of the world’s burden. Due to economic, infrastructure and skilled personnel constraints, the impact of cytology screening as a method for early detection and reducing mortality rates from cervical cancer is lower. Typically, women present with advanced disease that is difficult to treat because of de novo and pharmacokinetic resistance. Whilst the HPV vaccine is a welcome development in the fight against cervical cancer, for women who are outside the target age of vaccination, or indeed do not have access to vaccination, screening remains the only form of protection. Current excisional treatments available for cervical dysplasia are effective but have limitations, including increased incidence of obstetric complications and risk of recurrence. This is a particular issue in cases of HIV, which is endemic in the regions most affected by cervical cancer. Therefore, early detection combined with early treatment is an attractive strategy to reduce the number of women presenting with drug resistant disease in developing countries where cytology screening and vaccination services are poorly developed. This review makes the case for developing a locoregional treatment therapy for cervical dysplasia which could be incorporated into a cervical cancer screening strategy in a rural setting within a developing country.

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“…[3] and Pall et al . [4] However, there have been subtle differences in 5-FU administered by both authors [Table 1]. …”

mentioning

confidence: 99%

“…[6] Recently, intralesional usage of 5-FU at weekly intervals has been utilized for GW. [34] I, however, utilized 5-FU on a monthly basis. The reason for using this schedule was excruciating pain complained by my patient following the first intralesional session.…”

mentioning

confidence: 99%

Successful management of recalcitrant perianal warts with two sessions of intralesional 5-fluorouracil

Bubna

2016

Indian J Sex Transm Dis

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Therapeutic Evaluation of Intralesional 5% 5‐Fluorouracil in Condyloma Acuminata

Cited by 5 publications

References 47 publications

Comparison of the efficacy of intralesional5‐fluorouracil/lidocaine/epinephrine injection with cryotherapy to treat common and palmoplantar warts: A randomized, controlled trial

Comparison of the efficacy of intralesional5‐fluorouracil/lidocaine/epinephrine injection with cryotherapy to treat common and palmoplantar warts: A randomized, controlled trial

The Development of Locoregional Therapies as a Strategy for Reducing Cervical Cancer Mortality in Low to Middle Income Countries.

Successful management of recalcitrant perianal warts with two sessions of intralesional 5-fluorouracil

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