Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats

Castangia, Inés; Nácher, Amparo; Caddeo, Carla; Merino, Virginia; Dı́ez-Sales, Octavio; Catalán-Latorre, Ana; Fernàndez‐Busquets, Xavier; Fadda, Anna Maria; Manconi, Maria

doi:10.1016/j.actbio.2014.11.017

Cited by 74 publications

(44 citation statements)

References 32 publications

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“…Chronic inflammation in rat colon was chemically induced as previously described 6,13 , with slight modifications. Rats (n=4 per group) were anesthetized with isoflurane, and TNBS (0.13 M) dissolved in ethanol/water (50:50) was instilled (0.5 ml) into the colon lumen (day 0).…”

Section: Efficacy Of Curcumin Against Colitismentioning

confidence: 99%

“…Previous studies demonstrated that a daily dose of up to ~90 g of Nutriose ® is well tolerated in man and provides beneficial effects on intestinal flora 5 . Moreover, its use in pharmaceutical formulations can offer protection against colitis, in synergy with a natural flavonoid 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidant flavonoids have been widely used as protective and curative agents in intestinal pathologies, and chronic inflammatory colon disorders [7][8][9] . Their loading in nanoparticulate systems plays an important role in maximizing their efficacy, thanks to enhanced bioavailability and targeted delivery 6,10 .…”

Section: Introductionmentioning

confidence: 99%

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Nutriosomes: prebiotic delivery systems combining phospholipids, a soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

et al. 2018

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Nutriosomes, new phospholipid nanovesicles specifically designed for intestinal protection were developed by simultaneously loading a water-soluble dextrin (Nutriose® FM06) and a natural antioxidant (curcumin). Nutriosomes were easily fabricated in a one-step, organic solvent-free procedure. The stability and delivery performances of the vesicles were improved by adding hydroxypropyl methylcellulose. All the vesicles were small in size (mean diameter ∼168 nm), negatively charged (zeta potential ∼-38 mV, irrespective of their composition), and self-assembled predominantly in unilamellar vesicles stabilized by the presence of Nutriose®, which was located in both the inter-lamellar and inter-vesicle media, as confirmed by cryo-TEM and SAXS investigation. The dextrin acted also as a cryo-protector, avoiding vesicle collapse during the lyophilization process, and as a protector against high ionic strength and pH changes encountered in the gastrointestinal environment. Thanks to the antioxidant properties of curcumin, nutriosomes provided an optimal protective effect against hydrogen peroxide-induced oxidative stress in Caco-2 cells. Moreover, these innovative vesicles showed promising efficacy in vivo, as they improved the bioavailability and the biodistribution of both curcumin and dextrin upon oral administration, which acted synergically in reducing colonic damage chemically induced in rats.

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Section: Efficacy Of Curcumin Against Colitismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nutriosomes: prebiotic delivery systems combining phospholipids, a soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

et al. 2018

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“…These cross-linking interactions are physical in nature and reversible, but can provide the required properties for optimal drug delivery if the polymer is properly complexed. In a previous work, chitosan was complexed with Nutriose FM06 ® , a branched dextrin obtained from starch, and used to coat polyethylene glycol-containing vesicles, with the aim of producing an enzyme-sensitive, prebiotic, delayed release system for the delivery of quercetin to inflamed colon [14].…”

mentioning

confidence: 99%

Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin

Caddeo

Dı́ez-Sales

Pons³

et al. 2016

Journal of Colloid and Interface Science

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117

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1Quercetin is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when 2 administered orally. To increase its bioavailability and optimize its release in the intestine, a hybrid Scattering. 9The release of quercetin in simulated gastric and intestinal pH was investigated, the results showing 10 that the system provided resistance to acidic conditions, and promoted the release in alkaline pH, 11mimicking the intestinal environment. 12The proposed hybrid system represents a promising combination of nanovesicles and chitosan for

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“…Scientific literature reports the use of nanotechnologies approach to improve the stability and to enhance the therapeutic effect of plant constituents like polyphenols, tannins, alkaloids, terpenoids and herbal extracts [10][11][12][13][14].These innovative carriers are able, on one hand, to optimize some unfavourable chemical physical features of the natural active compounds, such as the solubility and the biological stability, while on the other hand, can improve their antioxidant/radical scavenging activity and promote their bioavailability [5][6][7][15][16][17]. The improving in antioxidant/radical scavenging activity of the active compound could be explained considering the protective effect against degradative phenomena derived from the encapsulation into the CDDS.…”

Section: Main Cdds Applied To Natural Active Compoundsmentioning

confidence: 99%

Modern drug delivery strategies applied to natural active compounds

Puglia

Lauro

Tirendi

et al. 2016

Expert Opinion on Drug Delivery

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Colloidal drug delivery systems (CDDSs) are innovative carriers that have been studied in pharmaceutical field from many years to overcome unfavorable physical and chemical features of synthetic drugs. Recently the use of CDDS as carriers for phytochemicals has seen an exponential increase which, in some cases, has led to the rediscovery of ancient and forgotten natural molecules. Area covered: This article focuses on the main features of CDDS, particularly micro- and nanoemulsions, vesicular carriers and micro- and nanoparticles, loaded with natural active compounds. A detailed review of the literature is presented, introducing the importance of these systems in terms of their capability to optimize the stability of phytochemicals, their absorption through biological membranes and their bioavailability. Expert opinion: The delivery of phytochemicals is problematic due to poor solubility, poor permeability, low bioavailability, instability in biological milieu and extensive first-pass metabolism. Global research efforts investigating nanotechnology have attempted to overcome these limitations rediscovering and, in some cases, 'discovering ex novo' unexpected virtues and benefits associated to these compounds. The 'nanotechnological approach' can definitely enhance the pharmacokinetics and therapeutic index of natural active compounds and improve their performance in therapy.

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Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats

Cited by 74 publications

References 32 publications

Nutriosomes: prebiotic delivery systems combining phospholipids, a soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

Nutriosomes: prebiotic delivery systems combining phospholipids, a soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin

Modern drug delivery strategies applied to natural active compounds

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