Therapeutic efficacy of ozone in patients with diabetic foot

Martı́nez-Sánchez, Gregorio; Al-Dalain, Saied Mohammed; Menéndez, Silvia; Re, Lamberto; Giuliani, Attilia; Candelario‐Jalil, Eduardo; Alvarez, Héctor M.; Fernández-Montequín, José I; León, Olga Sonia

doi:10.1016/j.ejphar.2005.08.020

Cited by 203 publications

(172 citation statements)

References 46 publications

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“…It enhances the oxygenation of tissues and triggers the secretion of cytokines 6 . It has been used as a therapeutic agent for chronic and diabetic wounds 7 . Ozone exerts its beneficial effects by supression of infection, regulation of inflammation and increasing local oxygen tension at the site of injury 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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PURPOSE:To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS:Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury.RESULTS: Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p<0.001) and inflammation in peripheral tissue (p=0.006).Degeneration was remarkably low in Group III, while no change in nerve sheath cell was noted in Group II. CONCLUSION:The combined use of methylprednisolone and ozone treatment can have beneficial effects for regeneration after crush type nerve injury.

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Section: Introductionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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“…Medical ozone, a mixture gas of ozone and oxygen, has been used for several decades in the therapy of diabetic foot, arthritis, arterial angiemphraxis and ulcerative colitis [1][2][3][4][5][6][7][8][9] . It has been used in an empirical fashion in recent years for therapy of viral hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs

Li¹

2007

WJG

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“…While the study group (n 5 52) received ozone therapy (local and rectal insufflation of the gas) the control group (n 5 49) received topical and systemic antibiotics. 3 After 20 days of treatment, although the healing rate was significantly higher in the ozone group (2.66 6 0.05 cm 2 /days vs. 1.21 6 0.01 cm 2 patients with diabetic foot ulcers were randomly assigned to ozone (n 5 32) and placebo (n 5 29) groups. 4 Only 34 (56%) of these patients completed the study.…”

Section: Discussionmentioning

confidence: 99%

Pitfalls of Intralesional Ozone Injection in Diabetic Foot Ulcers: A Case Study

Uzun

Mutluoğlu

Karagöz

et al. 2012

Journal of the American College of Clinical Wound Specialists

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Although the history of ozone therapy dates back to the 19th century, its use has shown a rapid growth of interest in recent decades. Intralesional ozone injection is seldom performed and its safety has not yet been reliably assessed for the treatment of diabetic foot wounds. Herein, we describe a diabetic patient who developed severe foot necrosis and infection after receiving intralesional ozone injections for a non-healing wound.

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Therapeutic efficacy of ozone in patients with diabetic foot

Cited by 203 publications

References 46 publications

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs

Pitfalls of Intralesional Ozone Injection in Diabetic Foot Ulcers: A Case Study

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