Therapeutic efficacy of intraperitoneally injected curcumin on experimentally induced hamster buccal pouch carcinoma

Abstract

Objective:The aim of the present study was directed to investigate the therapeutic efficacy of intraperitoneally injected curcumin as anticarcinogenic treatment modality on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch(s) (HBP(s)) carcinoma. Subjects and methods: Materials and Methods: Thirty Syrian male hamsters, five weeks old, weighing 90-130g were divided into three group(s) (G(s)): A, B, and C. G-A (negative control): HBP mucosa of 10 animals were painted with liquid paraffin alone three times a week for 14 weeks. G-B (positive control): 10 animals were painted with 0.5% DMBA in paraffin oil 3 times a week for 14 weeks. Then animals were left untreated for 6 weeks after DMBA painting. G-C (curcumin treated group): 10 animals were injected intraperitoneally with curcumin 80 mg/kg body weight every day for 6 weeks following DMBA-treatment. The assessment was based on the gross observation, histological and immunohistochemical examination utilizing anti-apoptotic Bcl-2 antibody. Results: Gross observation revealed variation in reduction of the tumor size in the treated group (G-C) compared to that observed in group G-B. Histopathological findings revealed variations between G-B and G-C groups. Immunohistochemical results revealed that Bcl-2 expression has a variability in the area % throughout the groups used. Groups G-A, G-B, and G-C were 7.78%, 75.51%, and 41.65% respectively. Conclusion: The therapeutic effect of intraperitoneally injected curcumin resulted in promising outcome in regression of DMBA induced HBP carcinoma.

Topical Chemotherapeutic Effect of Thymoquinone, Epigallocatechin-3-gallate, and Curcumin on Chemically Induced Oral Epithelial Dysplasia in Hamsters.

“…It has anti-inflammatory, antioxidant, anticancer, anti-ischemic, antifungal, and antibacterial effects. [7,8] One of the hallmarks of tumor progression is altered rates of cell proliferation through detection of proliferating cell nuclear antigen (PCNA). Also, dysregulation of apoptosis was found to be involved in the pathogenesis of cancer.…”