Therapeutic efficacy and promise of stem cell-derived extracellular vesicles in Alzheimer’s disease and other aging-related disorders

Rather, Hilal Ahmad; Almousa, Sameh; Craft, Suzanne; Deep, Gagan

doi:10.1016/j.arr.2023.102088

Cited by 8 publications

(1 citation statement)

References 238 publications

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“…Among those, EVs produced by stem cells are the most extensively studied. 120 In the UVBtriggered photoaging and natural senescence models, EVs released by human induced pluripotent stem cells (iPSCs) activated the proliferation and migration of fibroblasts, restored the collagen type I expression, as well as reduced the expression of MMP-1/3 and senescenceassociated β-galactosidase (SA-β-gal), a marker of senescence, in aged human dermal fibroblasts (HDFs), 70 indicating the therapeutic potential of iPSCs-derived EVs in the skin senescence. Mesenchymal stem cells (MSCs) are multipotent stem cells derived from various tissues, including the adipose, bone marrow, and umbilical cord.…”

Section: Skin Aging Ipscsmentioning

confidence: 99%

Extracellular vesicles in skin health, diseases, and aging

Wang,

Yuan,

et al. 2024

Interdisciplinary Medicine

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The skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. The dynamic interactions between various cell types are essential for skin homeostasis and function. Emerging research has unveiled the significant role of extracellular vesicles (EVs) as key mediators of cell communication in regulating many aspects of skin physiological and pathological processes. In this review, we provide an overview of recent advances in understanding the physiological and pathological roles of EVs in skin health, aging, and diseases, and discuss natural and engineered EVs in skin disease treatment along with the potential challenges. The burgeoning area of EVs may expand new therapeutic approaches for various skin disorders and open new avenues for personalized skincare treatments.

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Section: Skin Aging Ipscsmentioning

confidence: 99%