Therapeutic Effects of Withania somnifera: An Overview with Special Focus on Alzheimer’s Disease and Infertility among Youth

Saini, Deepika; Srivastava, Mansi; Vaid, Sandhya; Kesharwani, Vipin

doi:10.1007/978-981-19-2507-8_14

Cited by 2 publications

(2 citation statements)

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“…Researchers have hypothesised that the ashwagandha root extracts are effective in treating neurodegenerative illnesses and also promote neurite growth, and have anti-inflammatory, antiapoptotic, and anxiolytic effects. Moreover, they have the capacity to minimise mitochondrial dysfunctioning, boost antioxidant defence levels, reduce glutathione levels, and can cross the blood-brain barrier and reduce inflammation in the brain [200]. In a double-blind, randomized, placebocontrolled study, 50 participants with moderate cognitive impairment (MCI) were treated with a 300 mg dose of W. somnifera root extract twice daily for an eight-week period.…”

Section: Ashwagandhamentioning

confidence: 99%

“…Phytochemicals have been shown in in vitro and in vivo investigations to have a possibility for AD treatment, allowing for a few of them to go into the clinical trial phases [187]. According to research, phytochemicals can raise α-secretase activity, decrease Aβ formation, reduce tau hyperphosphorylation, increase antioxidant enzymes, and improve learning and memory [185,190,200], and shows significant potential in treating AD by acting on various mechanisms, as shown in Figure 3.…”

Section: Phytochemicalsmentioning

confidence: 99%

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Phytochemicals: A Promising Alternative for the Prevention of Alzheimer’s Disease

Koul

Farooq

Yadav

et al. 2023

Life

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Alzheimer’s disease (AD) is a neurological condition that worsens with ageing and affects memory and cognitive function. Presently more than 55 million individuals are affected by AD all over the world, and it is a leading cause of death in old age. The main purpose of this paper is to review the phytochemical constituents of different plants that are used for the treatment of AD. A thorough and organized review of the existing literature was conducted, and the data under the different sections were found using a computerized bibliographic search through the use of databases such as PubMed, Web of Science, Google Scholar, Scopus, CAB Abstracts, MEDLINE, EMBASE, INMEDPLAN, NATTS, and numerous other websites. Around 360 papers were screened, and, out of that, 258 papers were selected on the basis of keywords and relevant information that needed to be included in this review. A total of 55 plants belonging to different families have been reported to possess different bioactive compounds (galantamine, curcumin, silymarin, and many more) that play a significant role in the treatment of AD. These plants possess anti-inflammatory, antioxidant, anticholinesterase, and anti-amyloid properties and are safe for consumption. This paper focuses on the taxonomic details of the plants, the mode of action of their phytochemicals, their safety, future prospects, limitations, and sustainability criteria for the effective treatment of AD.

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Section: Ashwagandhamentioning

confidence: 99%

Section: Phytochemicalsmentioning

confidence: 99%

Phytochemicals: A Promising Alternative for the Prevention of Alzheimer’s Disease

Koul

Farooq

Yadav

et al. 2023

Life

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Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans

Zimmer,

Mueller,

Frank-Herrmann

et al. 2024

Cell Death Dis

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Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility. We used different study groups: individuals with Differences of Sex Development (DSD), including Complete Androgen Insensitivity Syndrome (CAIS) due to mutated androgen receptor (AR), and men with idiopathic nonobstructive azoospermia. Both showed genome integrity status influenced by androgen signaling via innate immune response activation in blood and gonads. Whole proteome analysis connected low AR to interleukin-specific gene expression, while compromised genome stability and tumorigenesis were also supported by interferons. AR expression was associated with predominant DNA damage phenotype, that eliminated AR-positive Sertoli cells as the degeneration of gonads increased. Low AR contributed to resistance from the inhibition of DNA repair in primary leukocytes. Downregulation of androgen promoted apoptosis and specific innate immune response with higher susceptibility in cells carrying genomic instability.

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Therapeutic Effects of Withania somnifera: An Overview with Special Focus on Alzheimer’s Disease and Infertility among Youth

Cited by 2 publications

References 50 publications

Phytochemicals: A Promising Alternative for the Prevention of Alzheimer’s Disease

Phytochemicals: A Promising Alternative for the Prevention of Alzheimer’s Disease

Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans

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