Therapeutic Effects of Systemic Vitamin K2 and Vitamin D3 on Gingival Inflammation and Alveolar Bone in Rats With Experimentally Induced Periodontitis

Aral, Kübra; Alkan, Banu Arzu; Saraymen, Recep; Yay, Arzu; Şen, Ahmet; Önder, Gözde Özge

doi:10.1902/jop.2015.140467

Cited by 24 publications

(24 citation statements)

References 40 publications

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“…The findings of the present study are in accordance with Aral, et al 3 (2015), which also demonstrated that vitamin D3 and vitamin K2 supplementation were not effective in the reduction of alveolar bone resorption in rats with experimentally induced periodontitis. Conversely, Hong, et al 13 (2015) recently demonstrated in dogs that vitamin D3 and calcium supplementation during the early stage of socket healing promoted accelerate bone regeneration, improving new bone formation, bone density, and reducing the extent of vertical ridge resorption.…”

Section: Discussionsupporting

confidence: 92%

“…Because trabecular bone contains marrow cavities, the BV/TV should be <100%. The VOI corresponded to dilatation of the implant shape of 25 voxels: the inners 5 layers of voxels were discarded to avoid the artifacts observed in this region, resulting in a VOI of 7.933 mm 3 , and the top of the VOI was placed on the implant neck. The BIC was also calculated in outside of these 5 layers of voxels.…”

Section: Methodsmentioning

confidence: 99%

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Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats

et al. 2016

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The use of natural substances and micronutritional approaches has been suggested as a therapeutic alternative to benefit the bone healing associated with no side effects. Nevertheless, the influence of micronutritional interventions with therapeutic proprieties on the bone repair has yet to be intensely evaluated, and no evidence is available exploring the impact of micronutrient supplementation on the peri-implant bone healing. Objective This study investigated the effect of micronutrients supplementation on the bone repair around implants.Material and Methods One screw-shaped titanium implant was inserted in each tibia of each rat, which were assigned to: daily administration, for 30 d, of the placebo solution (Placebo group-n:18) or micronutrients supplementation (Micronutrients group-n:18), based on calcium, magnesium, zinc, and vitamin D3 intake. After, the animals were sacrificed. One of the implants was removed by applying a counter-torque force to evaluate the force to rupture the bone-implant interface. The other implant was evaluated by microcomputed tomography (CT) examination to determine the bone-to-implant contact (BIC) and the bone volume (BV/TV).Results No statistically significant differences were observed between the groups for both counter-torque values and microCT parameters (p>0.05).Conclusion Within the limits of this study, micronutrients supplementation did not provide additional benefits to the bone healing around dental implants.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats

et al. 2016

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“…No significant differences were seen in the gingival contents of IL-1β and IL-10, blood B-ALP, TRAP-5b, and calcium, nor in alveolar bone mass between the groups receiving SRP and vitamins, and the experimental group receiving SRP alone. Furthermore, vitamin D3 and K2 alone, or combined, failed to affect gingival levels ofIL-1β and IL-10, as well as blood B-ALP and TRAP-5b, or the alveolar bone mass, as compared with traditional periodontal treatment per se [52].…”

Section: Some Recent Articles "Establishing" the Vitamin K2 Effect Onmentioning

confidence: 89%

Vitamin K2 and its Impact on Tooth Epigenetics

Gordeladze¹,

Landin²,

Johnsen³

et al. 2017

Vitamin K2 - Vital for Health and Wellbeing

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The impact of nutritional signals plays an important role in systemic-based «models» of dental caries. Present hypotheses now focus both on the oral environment and other organs, like the nervous system and brain. The tooth is subjected to shear forces, nourishing and cleansing, and its present "support system" (the hypothalamus/parotid axis) relays endocrine signaling to the parotid gland. Sugar consumption enhances hypothalamic oxidative stress (ROS), reversing dentinal fluid flow, thus creating an enhanced vulnerability to the oral bacterial flora. The acid, produced by the oral bacterial flora, then leads to erosion of the dentine, and an irreversible loss of dental enamel layers. This attack brings about inflammatory responses, yielding metalloproteinase-based "dissolution". However, vitamin K2 (i.e. MK-4/MK-7) may come to the rescue with its antioxidant property, locally (mouth cavity) or systemically (via the brain), thus sustaining/preserving hormone-induced dentinal fluid flow (encompassing oxidative stress) and boosting/magnifying bodily inflammatory responses. However, sugars may also reduce the tooth's natural defences through endocrine signaling, thus enhancing acid-supported enamel dentine erosion. Vitamin K2 sustains and improves the salivary buffering capacity via its impact on the secretion/flow of calcium and inorganic phosphates. Interestingly, primitive cultures' diets (low-sugar and high-K2 diets) preserve dental health.

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“…We, therefore, think that there is a significant positive correlation between the presence of periodontal disease and low intake of magnesium in not only the elderly but also in young adults. Both animal and human studies have reported that a lack of calcium intake leads to alveolar bone resorption [34, 35] and a decrease in bone density [36], indicating that insufficient calcium intake might cause the progression of periodontal disease. In addition, it was shown that the risk of periodontal disease associated with calcium intake was observed in both men and women aged between 20 and 39 years (odds ratio; 1.99 and 1.84), only in men aged between 40 and 59 years, and in neither men nor women aged ≥60 years [37].…”

Section: Discussionmentioning

confidence: 99%

The association between dietary habits and periodontal disease in young adult women

Hosoda

Komagamine

Kanazawa

et al. 2019

Preprint

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Therapeutic Effects of Systemic Vitamin K2 and Vitamin D3 on Gingival Inflammation and Alveolar Bone in Rats With Experimentally Induced Periodontitis

Abstract: Within the limitations of this study, vitamin D3 and K2 alone or in combination did not affect gingival IL-1β and IL-10, serum B-ALP and TRAP-5b levels, or alveolar bone compared with conventional periodontal therapy alone.

Cited by 24 publications

References 40 publications

Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats

Impact of micronutrients supplementation on bone repair around implants: microCT and counter-torque analysis in rats

Vitamin K2 and its Impact on Tooth Epigenetics

The association between dietary habits and periodontal disease in young adult women

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