2001
DOI: 10.1097/00006123-200103000-00035
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Therapeutic Effects of Sodium Butyrate on Glioma Cells in Vitro and in the Rat C6 Glioma Model

Abstract: These data support further consideration of direct interstitial infusion of sodium butyrate in a Phase I clinical study for patients with recurrent glioblastoma multiforme.

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Cited by 39 publications
(24 citation statements)
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“…That is, these data suggest that at clinically achievable serum concentrations (1-10 mM), VPA may have significant anti-GBM effects as a monotherapy. Interestingly these concentrations are in the range of the anti-proliferative concentration of 2 mM seen in the treatment of primary and established glioma cells with commonly used HDACi, butyrate [27]. Subsequently, three of the five cultures assayed showed uniformly additive effects when a clinically relevant concentration of VPA (1 mM) was added 24 h before treatment with TMZ and/or irradiation.…”
Section: Discussionmentioning
confidence: 94%
“…That is, these data suggest that at clinically achievable serum concentrations (1-10 mM), VPA may have significant anti-GBM effects as a monotherapy. Interestingly these concentrations are in the range of the anti-proliferative concentration of 2 mM seen in the treatment of primary and established glioma cells with commonly used HDACi, butyrate [27]. Subsequently, three of the five cultures assayed showed uniformly additive effects when a clinically relevant concentration of VPA (1 mM) was added 24 h before treatment with TMZ and/or irradiation.…”
Section: Discussionmentioning
confidence: 94%
“…The C6 orthotropic glioma model is simple, reliable, and easily reproducible, which has been extensively used to study growth kinetics, mechanisms of angiogenesis, as well as the expression of growth factors and receptors involved in the progression of astrocytic tumor [10,26]. Many studies indicate that the C6 glioma model best mimics the cell biological stages of early glioma progression in human.…”
Section: Discussionmentioning
confidence: 99%
“…Note that relatively few examples of retro virus-mediated transfer of the p16 cDNA in animal models of glioma are reported in the literature [29], although using a different cell line and several reports demonstrate the adeno viral transfer of p16 [30-32]. The C6/Wistar rat model continues to be widely used [33,34] and this study adds a new component to this system: retrovirus-mediated transfer followed by assessment of p1 6 function in tissue culture and in vivo. The p1 6 protein acts through a well defined pathway and has strong suppressive activity in experimental models, including the C6/Wistar rat system.…”
Section: Discussionmentioning
confidence: 99%