Brainstem glioma progression in juvenile and adult rats

Liu, Qing; Liu, Ran; Kashyap, Meghana V.; Agarwal, Rajnee; Shi, Xiaoyan; Wang, Chung Cheng; Yang, Shao Hua

doi:10.3171/jns/2008/109/11/0849

Cited by 17 publications

(21 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats in groups A and C exhibited a ‘decrease-increase-decrease’ pattern of weight gain, which is in contrast with the data reported by Liu et al (19). Subsequent to implantation, the stress response following surgery and anesthesia caused a short-term reduction in eating and drinking, which resulted in weight loss.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Differences between brainstem gliomas in juvenile and adult rats

et al. 2013

View full text Add to dashboard Cite

Clinical studies have shown that gliomas of the brainstem behave differently in children and adults. The aim of the present study was to compare and analyze the differences between these gliomas in juvenile and adult rats with regard to tumor growth, survival, pathology and magnetic resonance imaging (MRI). A total of 25 juvenile and 25 adult Wistar rats were divided into groups A (15 juvenile rats), B (10 juvenile rats), C (15 adult rats) and D (10 adult rats). The rats of groups A and C (experimental) were injected with glioma cells, while groups B and D (control) were injected with a physiological saline solution. Rat neurological signs, survival time, tumor size, hematoxylin and eosin (HE) staining and immunohistochemical staining for MMP-2, MMP-9 and β-catenin were compared. The survival time of group A was 19.47±2.232 days, whereas that of group C was 21.47±2.232 days (P<0.05). The tumor sizes were 4.55 and 4.62 mm (P>0.05) in groups A and C, respectively. HE and immunohistochemical staining revealed no differences between the groups. The results suggest that the growth patterns and invasiveness of brainstem gliomas may vary in children compared with adults due to the varied biological behaviors of the tumor cells.

show abstract

Section: Discussioncontrasting

confidence: 99%

“…Additionally, in the present study, hydrocephalus appeared earlier in the juvenile rats, which resulted in shorter survival times. This is consistent with the results from a study by Liu et al (19). …”

Section: Discussionsupporting

confidence: 94%

Differences between brainstem gliomas in juvenile and adult rats

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In an animal model of brainstem glioma, the authors found that the tumors were more diffuse in young rats and relatively focal in adult rats. Furthermore, brainstem gliomas in young rats were more proliferative and had less apoptotic cells than those in adult rats [20]. Their findings suggested that the growth pattern and invasiveness differed between the groups.…”

Section: International Journal Of Neurosciencementioning

confidence: 96%

Expression of β-catenin and E- and N-cadherin in human brainstem gliomas and clinicopathological correlations

Tian

Wan

et al. 2013

International Journal of Neuroscience

View full text Add to dashboard Cite

Brainstem gliomas are usually associated with serious dysfunction and poor prognosis especially for diffuse intrinsic brainstem gliomas; however, the reasons are still unclear. Some clinical studies have suggested that the invasive ability may be different among brainstem gliomas, and the dysfunction of β-catenin and E- and N-cadherin appears to be connected with tumor invasion and progression. In this study, the expression of β-catenin and E- and N-cadherin was detected in 40 brainstem glioma samples using immunochemistry and was further analyzed in 18 samples using reverse transcription-polymerase chain reaction. The clinicopathological characteristics were also analyzed. The results show that there was no obvious staining for E-cadherin, but weak expression at the messenger RNA (mRNA) level could be seen in a few samples. The protein and mRNA expression levels of β-catenin and N-cadherin were significantly associated with the pathological grades of brainstem gliomas. No significant differences in the expression levels of β-catenin and N-cadherin were observed for age, sex, location or diffuse growing pattern. The overall survival of patients with low β-catenin expression was longer than that with high β-catenin expression, and there was a trend toward increased expression of N-cadherin with shorter survival; however, both of them had no statistical differences. These results demonstrate that expression of β-catenin and N-cadherin is associated with the malignant progression of brainstem gliomas but not correlated with the diffuse and invasive growing pattern. β-catenin and N-cadherin are potential therapeutic targets and prognostic markers for brainstem glioma, which need to be validated in a larger patient cohort.

show abstract

“…These and other data suggest that BSG is a unique glioma subtype with biological and molecular pathology mechanisms different from common gliomas (6). Discerning the key differences between pediatric and adult BSG may prove indispensable to the fight against pediatric BSG (10), a fight that has not yielded many positive victories in recent years (1).…”

Section: Introductionmentioning

confidence: 92%

Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas

Wang

Zhang

et al. 2012

Oncology Reports

Self Cite

View full text Add to dashboard Cite

Brainstem glioma (BSG) is an entity which commonly occurs in pediatric patients and carries a dismal prognosis. However, the category of adult BSG has displayed considerably benign biological behavior, thus providing a unique perspective to comparatively understand the malignant features of pediatric BSG. microRNAs (miRNAs) have been associated with cancer development and progression. To identify miRNAs specifically involved in the acquisition of malignant progression of pediatric BSG, we analyzed the miRNA expression profiles in orthotopic models which could simulate the BSG heterogeneity by microarrays. Our research revealed that miR-20a and miR-106b (known to be closely related) were the two most robust upregulated miRNAs in pediatric BSG compared to adult subtype. Furthermore, the two types of human BSG tissue were utilized to verify the microarray data by qRT-PCR and in situ hybridization. The results indicated good consistency with that of the microarray method. In conclusion, our studies provide evidence that miR-20a and miR-106b may serve as putative causative involvement of malignant progression of pediatric BSG, thereby serving as likely novel targets for constraining the rapid fatal course of pediatric BSG.

show abstract

Brainstem glioma progression in juvenile and adult rats

Cited by 17 publications

References 40 publications

Differences between brainstem gliomas in juvenile and adult rats

Differences between brainstem gliomas in juvenile and adult rats

Expression of β-catenin and E- and N-cadherin in human brainstem gliomas and clinicopathological correlations

Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas

Contact Info

Product

Resources

About