Therapeutic Effects of Royal Jelly on Some Biochemical Parameters in Nephrotoxicity Induced by Carbon Tetrachloride (Ccl4) In Albino Rats.

Abstract

The present study was designed to determine the possible therapeutic effects of royal jelly against carbon tetrachloride (CCl4) induced oxidative stress and biochemical changes in the kidney of albino rats. A patch of 20 male albino rats averaged weights (190±10 g) at the beginning of the experiment were divided into 4 main groups according to the treatment and requirements of the experiment. The rats injected i.p. with CCl4 at a dose (1 mL/kg, 1:1 in olive oil) twice per week and received, via gavage, royal jelly at a dose (400 mg/kg b. wt) along the experimental period. Each group contains 5 rats that were sacrificed on the45 days from the start of the experiment. The results refer to a significant elevation of renal parameters (creatinine, blood Urea and Uric acid) on the 6 th week in rats injected intraperitoneal with CCl4 as compared to the control groups. The administration of the royal jelly has beneficial and decrease side effects against the deleterious changes of CCl4.In conclusion, according to the results obtained the administration of the royal jelly provides considerable nephroprotective effects against intoxicated with CCl4 in male Wister albino rats by preventing oxidative stress through ROS scavenger and improvement in the former biochemical parameters.

Ameliorative Effects of Propolis and Royal Jelly against CCl4‐Induced Hepatotoxicity and Nephrotoxicity in Wistar Rats

“…Improvements in red blood cells and hemoglobin content was recorded after royal jelly administration in CCl 4 ‐induced liver injury in rats. Royal jelly may have positive nephroprotective effects on the ethylene glycol and CCl 4 induced renal injury [23,24] …”

“…Royal jelly may have positive nephroprotective effects on the ethylene glycol and CCl 4 induced renal injury. [23,24] Given that CCl 4 is associated with significant liver and kidney injury, the aim of this study is to investigate the potential effectiveness of propolis and royal jelly against CCl 4 -induced hepato-renal damage.…”

Therapeutic benefit of oregano oil in the acute idiosyncratic hepatotoxicity induced by carbon tetrachloride in rats: Adverse effects of high dose of oreganum

“…CCl 4 in a concentration of 1 mL/kg diluted in olive oil 1:1 (approximately 0.22 mL per animal in relation to the mean body weight) was administered twice a week, via oral gavage. The dose criterion was taken in accordance with the research of Ali et al 18 and Suljević et al 19 Oregano oil ( Origanum minutiflorum extract, OME; Probotanic) in a concentration of 20 and 60 mg/kg dissolved in 1 mL of olive oil was given three times a week, via oral gavage 20,21 . OME is commercially available pure organic oil intended for oral consumption.…”

Impact of dietary supplementation with chokeberry (Aronia melanocarpa, Michx.) on tetrachloride‐induced liver injury in Wistar rats: Hematological and biochemical implication

“…of CCl 4 twice a week for 2 weeks was used to induce liver injury. Dosing criteria and exposure time were based on previous studies 30,31 …”

“…Dosing criteria and exposure time were based on previous studies. 30,31 The animals were divided into groups as follows.…”