Therapeutic effects of rosmarinic acid on airway responses in a murine model of asthma

Liang, Zhengmin; Nie, Haiying; Xu, Yangfeng; Peng, Jianbo; Zeng, Yun; Wei, Ying‐Yi; Wen, Xiaoyan; Qiu, Jiazhang; Zhong, Weiying; Deng, Xuming; He, Jiakang

doi:10.1016/j.intimp.2016.10.010

Cited by 46 publications

(34 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We hypothesize that the lower dose of 5 mg/kg might exert beneficial effects if the treatment duration is lengthened to one week or ten days. Our other study, in which we evaluated the therapeutic effects of RA (20 mg/kg) administered after Ova challenge for 1 h on Ova-induced mice, also demonstrated its strong protective effects in a mouse model of asthma [45]. Therefore, the effective dose of RA is lower than those of other active components that we have reported in previous studies, for example, the effective dose of emodin [46] and ginkgolide B [47] are 40 mg/kg, and that of geniposide [48] is 80 mg/kg.…”

Section: Resultsmentioning

confidence: 99%

Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

Liang

Wen

et al. 2016

Molecules

Self Cite

View full text Add to dashboard Cite

Rosmarinic acid (RA) has numerous pharmacologic effects, including anti-oxidant, anti-inflammatory, and analgesic effects. This study aimed to evaluate the preventive activity of RA in a murine model of asthma and to investigate its possible molecular mechanisms. Female BALB/c mice sensitized and challenged with ovalbumin (Ova) were pretreated with RA (5, 10 or 20 mg/kg) at 1 h before Ova challenge. The results demonstrated that RA markedly inhibited increases in inflammatory cells and Th2 cytokines in the bronchoalveolar lavage fluid (BALF), significantly reduced the total IgE and Ova-specific IgE concentrations, and greatly ameliorated airway hyperresponsiveness (AHR) compared with the control Ova-induced mice. Histological analyses showed that RA substantially decreased the number of inflammatory cells and mucus hypersecretion in the airway. In addition, our results suggested that the protective effects of RA might be mediated by the suppression of ERK, JNK and p38 phosphorylation and activation of nuclear factor-κB (NF-κB). Furthermore, RA pretreatment resulted in a noticeable reduction in AMCase, CCL11, CCR3, Ym2 and E-selectin mRNA expression in lung tissues. These findings suggest that RA may effectively delay the progression of airway inflammation.

show abstract

Section: Resultsmentioning

confidence: 99%

Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

Liang

Wen

et al. 2016

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…AHR has been used in epidemiological studies as a useful marker of airway abnormalities in asthma, and it is a predictor of the subsequent course of the disease 21. It is believed that inflammatory mediators released during the allergic inflammation play a critical role in AHR development 22.…”

Section: Discussionmentioning

confidence: 99%

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

et al. 2017

View full text Add to dashboard Cite

Asthma is a chronic respiratory disease characterized by airway inflammation and remodeling, resulting in a substantial economic burden on both patients and society. Deguelin, a constituent of the Leguminosae family, exhibits anti-proliferative and anti-inflammatory activities in cancer mice models via inhibiting phosphatidylinositol 3-kinases and the NF-κB pathway. We demonstrated that deguelin effectively reduced OVA-induced inflammatory cell recruitment, decreased lung tissue inflammation and mucus production, suppressed airway hyperresponsiveness, and inhibited serum immunoglobulin and Th2 cytokine levels in a dose-dependent manner in asthmatic mice. In addition, we found that deguelin reduced inflammatory gene expressions both in vivo and in vitro, which were closely associated with activation of the NF-κB signaling pathway. Thus, we further explored the underlying mechanisms of deguelin in normal human bronchial epithelial cells (BEAS-2B). Our results suggested that deguelin inhibited NF-κB binding activity by enhancing the ability of IκBα to maintain NF-κB in an inactive form in the cytoplasm and preventing the TNF-α induced translocation of p65 to the nucleus. In conclusion, our research indicates that deguelin attenuates allergic airway inflammation via inhibition of NF-κB pathway in mice model and may act as a potential therapeutic agent for patients with allergic airway inflammation.

show abstract

“…Changes in the number of goblet cells and production of mucus are key to airway inflammation and obstruction (8). The mitogen-activated protein kinase (MAPK) signaling pathways have an important role in the inflammatory processes of allergic asthma (9). The activation of c-Jun N-terminal kinase (JNK) has been implicated in IgE class switching (10).…”

Section: Introductionmentioning

confidence: 99%

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

et al. 2019

View full text Add to dashboard Cite

Pistacia weinmannifolia (Anacardiaceae) has been used in herbal medicine for the treatment of influenza, dysentery and enteritis in china. It was recently observed that P. weinmannifolia root extract (PWRE) exerts anti-inflammatory effects both in in vitro and in vivo models. Based on the results from previous studies, the present study investigated the protective effect of PWRE on airway inflammation and mucus hypersecretion. Treatment with PWRE significantly decreased the number of eosinophils and the levels of Th2 cytokines, such as interleukin (IL)-4, IL-5 and IL-13, in the bronchoalveolar lavage fluid (BALF) of OVA-exposed mice. PWRE decreased the high serum levels of total and OVA-specific immunoglobulin E. PWRE also effectively inhibited the influx of inflammatory cells into the lung, as well as airway mucus hypersecretion. In addition, the increased level of monocyte chemoattractant protein-1 was significantly decreased with the PWRE treatment in the BALF of OVA-exposed mice and in lipopolysaccharide-stimulated RAW264.7 macrophages. These protective effects of PWRE on OVA-induced pulmonary inflammation were accompanied by the downregulation of mitogen associated protein kinases and nuclear factor-κB activation. Thus, the results from the present study indicate that PWRE could be valuable adjuvant for the treatment of asthma.

show abstract

Therapeutic effects of rosmarinic acid on airway responses in a murine model of asthma

Cited by 46 publications

References 51 publications

Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

Contact Info

Product

Resources

About