Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

Liang, Zhengmin; Xu, Yangfeng; Wen, Xiaoyan; Nie, Haiying; Hu, Ting‐Jun; Yang, Xiaofeng; Chu, Xiao; Yang, Jian; Deng, Xuming; He, Jiakang

doi:10.3390/molecules21060769

Cited by 49 publications

(26 citation statements)

References 49 publications

(62 reference statements)

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“…Data of the present study showed that RA treatment exhibited anti-inflammatory effects as evidenced by a significant decrease in kidney level of proinflammatory marker TNF-α. Similar antiinflammatory effects of RA were obtained in different models of inflammatory diseases 11,62 . The anti-inflammatory properties of RA were proven to be attained through the inhibition of COX-2 and inhibition of production of inflammatory chemokines and cytokines 63 .…”

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confidence: 77%

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2018

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The present study aimed to investigate the anticancer effect of rosmarinic acid (RA), both alone and in combination with cisplatin (cis). Also, the potential nephroprotective effects of RA against cis-induced nephrotoxicity in mice and the possible mechanisms underlying this protection were explored. Treatment of HepG2 cells with RA produced a significant decline in cellular proliferation. RA induced cell cycle arrest at G 0 / G 1 phase and S phase, significantly inhibited vascular endothelial growth factor (VEGF) concentration and induced caspase-3 level in cell lysate. While pre-treatment with IC 50 RA before cis addition significantly enhanced cis cytotoxic activity in HepG2 cells. Moreover, Pre-treatment with RA significantly mitigated cis-induced elevation of blood urea nitrogen (BUN) and serum creatinine levels. The elevated levels of malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), Bax and caspase-9 in kidney tissues were significantly reversed. Additionally, RA significantly abrogated cis-induced reduction in reduced glutathione level (GSH). The histopathological examination emphasized the obtained results. Conclusion: RA possesses cytotoxic activity against HepG2 cell line through cell cycle arrest, induction of caspase-3 and inhibition of VEGF. In addition, RA enhances cis-induced cytotoxicity in HepG2 cells. Also, it ameliorates cis-induced nephrotoxicity in mice; an effect which could be attributed to inhibition of oxidative stress, inflammation and apoptosis.

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confidence: 77%

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2018

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“…RosA has been found to inhibit ovalbumin (Ova)-stimulated airway inflammation in a mouse model of asthma (Liang et al, 2016). The mitogen-activated protein kinases (MAPKs) regulate the synthesis and secretion of pro-inflammatory mediators during the inflammatory process, and their family contains three different stress-activated protein kinase pathways: p38, JNK, and ERK .…”

Section: Asthmamentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the antiinflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including antioxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The antiinflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the antiinflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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“…The mitogen-activated protein kinase (MAPK) family consisting of three different stress-activated protein kinase pathways namely p38, JNK and ERK, has been found to modulate the level of IL-5 and other cytokines during inflammation. Therefore, MAPK pathway can also be used as a potential molecular target for the treatment of chronic inflammatory diseases [ 14 ] (Fig. 1 ).…”

Section: Molecular Pathways Linked To Inflammationmentioning

confidence: 99%

Chronic diseases, inflammation, and spices: how are they linked?

et al. 2018

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Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. It is now well established that these factors induce chronic diseases through induction of inflammation. However, inflammation could be either acute or chronic. Acute inflammation persists for a short duration and is the host defense against infections and allergens, whereas the chronic inflammation persists for a long time and leads to many chronic diseases including cancer, cardiovascular diseases, neurodegenerative diseases, respiratory diseases, etc. Numerous lines of evidence suggest that the aforementioned risk factors induced cancer through chronic inflammation. First, transcription factors NF-κB and STAT3 that regulate expression of inflammatory gene products, have been found to be constitutively active in most cancers; second, chronic inflammation such as pancreatitis, prostatitis, hepatitis etc. leads to cancers; third, activation of NF-κB and STAT3 leads to cancer cell proliferation, survival, invasion, angiogenesis and metastasis; fourth, activation of NF-κB and STAT3 leads to resistance to chemotherapy and radiation, and hypoxia and acidic conditions activate these transcription factors. Therefore, targeting these pathways may provide opportunities for both prevention and treatment of cancer and other chronic diseases. We will discuss in this review the potential of various dietary agents such as spices and its components in the suppression of inflammatory pathways and their roles in the prevention and therapy of cancer and other chronic diseases. In fact, epidemiological studies do indicate that cancer incidence in countries such as India where spices are consumed daily is much lower (94/100,000) than those where spices are not consumed such as United States (318/100,000), suggesting the potential role of spices in cancer prevention.

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Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma

Cited by 49 publications

References 49 publications

Untitled

Untitled

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

Chronic diseases, inflammation, and spices: how are they linked?

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