Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review

Abstract

Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.

Erxian Decoction‐induced serum exosomes slowed bone marrow mesenchymal stem cell senescence through mitophagy

“…With age and the accumulation of damaged macromolecules in the body, the function of tissues and organs gradually declines. [50][51][52][53] Stem cell senescence is an important cause of organism aging, which is closely related to degenerative diseases. [54][55][56][57] For instance, BMSC dysfunction has been shown to be an important cause of osteoporosis, where senescent BMSCs develop dysfunction, their self-renewal capacity is reduced, osteogenic differentiation is reduced, and they tend toward adipogenic differentiation.…”

“…Senescence is a complex natural process. With age and the accumulation of damaged macromolecules in the body, the function of tissues and organs gradually declines 50–53 . Stem cell senescence is an important cause of organism aging, which is closely related to degenerative diseases 54–57 .…”

Tanshinone IIA ameliorates cisplatin‐induced toxicology and cisplatin resistance via regulating SLC7A11 expression

“…Cisplatin, a platinum‐based chemotherapeutic agent, has revolutionized cancer treatment due to its potent anticancer properties 1,2 . Since its introduction in the 1970s, cisplatin has become a cornerstone in the treatment of various solid tumors, including testicular, ovarian, bladder, and lung cancers.…”