Therapeutic Effects of High-Intensity Interval Training Exercise Alone and Its Combination with Ecdysterone Against Amyloid Beta-Induced Rat Model of Alzheimer’s Disease: A Behavioral, Biochemical, and Histological Study

Gholipour, Parsa; Komaki‬, Alireza; Parsa, Hesam; Ramezani, Mahdi

doi:10.1007/s11064-022-03603-2

Cited by 20 publications

(8 citation statements)

References 88 publications

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“…showed that Aβ injection led to impairment in cognitive memory in rats, which is consistent with previous studies Gholipour et al, 2022). According to the results of the present study, the time spent exploring the novel object and familiar object in the acetylcholinesterase activity in the brain (Goverdhan et al, 2012).…”

Section: Discussionsupporting

confidence: 93%

“…The effects of SEL treatment on cognitive memory were assessed using the NOR, PAL, and MWM tests in the present study. The results showed that Aβ injection led to impairment in cognitive memory in rats, which is consistent with previous studies (Ahmadi et al., 2021; Gholipour et al., 2022). According to the results of the present study, the time spent exploring the novel object and familiar object in the NOR test was almost the same in the AD group, indicating impairment in object recognition memory.…”

Section: Discussionsupporting

confidence: 92%

“…The video tracking software (Borjsanat Co) analyzed the locomotor activity of the rats inside the box using a camera placed on top of the box. The rats were transferred to the testing room 30 min before the start of the experiment to acclimate to the environment (Gholipour et al., 2022). Each rat was placed in the center of the box to freely explore for 10 min.…”

Section: Methodsmentioning

confidence: 99%

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Protective effects of selegiline against amyloid beta‐induced anxiety‐like behavior and memory impairment

Mohamadpour,

Mirazi,

Komaki

et al. 2024

Brain and Behavior

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BackgroundAlzheimer's disease (AD) is a complex and common neurodegenerative disorder. The present study aimed to investigate the potential effects of selegiline (SEL) on various aspects of memory performance, anxiety, and oxidative stress in an AD rat model induced by intracerebroventricular injection of amyloid beta1‐42 (Aβ1‐42).MethodsOral administration of SEL at a dose of 0.5 mg/kg/day was performed for 30 consecutive days. Following the 30 days, several tests, including the open‐field, elevated plus‐maze, novel object recognition, Morris water maze, and passive avoidance learning were conducted to assess locomotor activity, anxiety‐like behavior, recognition memory, spatial memory, and passive avoidance memory, respectively.ResultsThe results indicate that the induction of AD in rats led to recognition memory, spatial memory, and passive avoidance memory impairments, as well as increased anxiety. Additionally, the AD rats exhibited a decrease in total antioxidant capacity and an increase in total oxidant status levels, suggesting an imbalance in oxidative‐antioxidant status. However, the administration of SEL improved memory performance, reduced anxiety, and modulated oxidative‐antioxidant status in AD rats.ConclusionsThese findings provide evidence that SEL may alleviate anxiety‐like behavior and cognitive deficits induced by Aβ through modulation of oxidative‐antioxidant status.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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Protective effects of selegiline against amyloid beta‐induced anxiety‐like behavior and memory impairment

Mohamadpour,

Mirazi,

Komaki

et al. 2024

Brain and Behavior

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“…The results showed that exercise pre-training reduced Aβ deposition and tau hyperphosphorylation, inhibited mitochondrial dynamic imbalance, and significantly inhibited oxidative stress and neuroinflammation in AD rats ( Yang et al, 2022 ). Another study ( Gholipour et al, 2022 ) reported the effect of high-intensity interval training on AD. The results showed that high-intensity interval training can reduce hippocampal oxidative stress and Aβ deposition, reduce neuronal damage, and improve AD symptoms.…”

Section: Discussionmentioning

confidence: 99%

Research trends and hotspots of exercise for Alzheimer’s disease: A bibliometric analysis

Chen

Song

et al. 2022

Front. Aging Neurosci.

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ObjectiveAlzheimer’s disease (AD) is a socially significant neurodegenerative disorder among the elderly worldwide. An increasing number of studies have revealed that as a non-pharmacological intervention, exercise can prevent and treat AD. However, information regarding the research status of this field remains minimal. Therefore, this study aimed to analyze trends and topics in exercise and AD research by using a bibliometric method.MethodsWe systematically searched the Web of Science Core Collection for published papers on exercise and AD. The retrieved data regarding institutions, journals, countries, authors, journal distribution, and keywords were analyzed using CiteSpace software. Meanwhile, the co-occurrence of keywords was constructed.ResultsA total of 1,104 papers were ultimately included in accordance with our specified inclusion criteria. The data showed that the number of published papers on exercise and AD is increasing each year, with papers published in 64 countries/regions and 396 academic journals. The Journal of Alzheimer’s Disease published the most papers (73 publications). Journals are concentrated in the fields of neuroscience and geriatrics gerontology. The University of Kansas and the United States are the major institution and country, respectively. The cited keywords show that oxidative stress, amyloid beta, and physical exercise are the research hotspots in recent years. After analysis, the neuroprotective effect of exercise was identified as the development trend in this field.ConclusionsBased on a bibliometric analysis, the number of publications on exercise and AD has been increasing rapidly, especially in the past 10 years. “Amyloid beta,” “oxidative stress,” and “exercise program” trigger the most interest among researchers in this field. The study of exercise program and mechanism of exercise in AD is still the focus of future research.

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“…The encoding of spatial memory relies on the capture of behaviorally relevant spatial cues on a timescale of seconds, which is known as spatial working memory [ 8 ]. Moreover, the hippocampus is highly vulnerable to oxidative stress under hypoxia and multiple diseases [ 9 ]. This vulnerability contributes to the characteristic memory and learning impairments observed in pathologies like Alzheimer’s disease (AD), addiction or major depression, among others [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

Jiménez-Herrera,

Contreras,

Djebari

et al. 2023

Biol Sex Differ

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Background The amyloid-β (Aβ) cascade is one of the most studied theories linked to AD. In multiple models, Aβ accumulation and dyshomeostasis have shown a key role in AD onset, leading to excitatory/inhibitory imbalance, the impairments of synaptic plasticity and oscillatory activity, and memory deficits. Despite the higher prevalence of Alzheimer’s disease (AD) in women compared to men, the possible sex difference is scarcely explored and the information from amyloidosis transgenic mice models is contradictory. Thus, given the lack of data regarding the early stages of amyloidosis in female mice, the aim of this study was to systematically characterize the effect of an intracerebroventricular (icv.) injection of Aβ1–42 on hippocampal-dependent memory, and on associated activity-dependent synaptic plasticity in the hippocampal CA1–CA3 synapse, in both male and female mice. Methods To do so, we evaluated long term potentiation (LTP) with ex vivo electrophysiological recordings as well as encoding and retrieval of spatial (working, short- and long-term) and exploratory habituation memories using Barnes maze and object location, or open field habituation tasks, respectively. Results Aβ1–42 administration impaired all forms of memory evaluated in this work, regardless of sex. This effect was displayed in a long-lasting manner (up to 17 days post-injection). LTP was inhibited at a postsynaptic level, both in males and females, and a long-term depression (LTD) was induced for the same prolonged period, which could underlie memory deficits. Conclusions In conclusion, our results provide further evidence on the shifting of LTP/LTD threshold due to a single icv. Aβ1–42 injection, which underly cognitive deficits in the early stages of AD. These long-lasting cognitive and functional alterations in males and females validate this model for the study of early amyloidosis in both sexes, thus offering a solid alternative to the inconsistence of amyloidosis transgenic mice models.

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Therapeutic Effects of High-Intensity Interval Training Exercise Alone and Its Combination with Ecdysterone Against Amyloid Beta-Induced Rat Model of Alzheimer’s Disease: A Behavioral, Biochemical, and Histological Study

Cited by 20 publications

References 88 publications

Protective effects of selegiline against amyloid beta‐induced anxiety‐like behavior and memory impairment

Protective effects of selegiline against amyloid beta‐induced anxiety‐like behavior and memory impairment

Research trends and hotspots of exercise for Alzheimer’s disease: A bibliometric analysis

Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

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