Protective effects of selegiline against amyloid beta‐induced anxiety‐like behavior and memory impairment
Behnam Mohamadpour,
Naser Mirazi,
Alireza Komaki
et al.
Abstract:BackgroundAlzheimer's disease (AD) is a complex and common neurodegenerative disorder. The present study aimed to investigate the potential effects of selegiline (SEL) on various aspects of memory performance, anxiety, and oxidative stress in an AD rat model induced by intracerebroventricular injection of amyloid beta1‐42 (Aβ1‐42).MethodsOral administration of SEL at a dose of 0.5 mg/kg/day was performed for 30 consecutive days. Following the 30 days, several tests, including the open‐field, elevated plus‐maze… Show more
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