Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study

Kamiya, Tetsuro; Shikano, Michiko; Tanaka, Mamoru; Ozeki, Keiji; Ebi, Masahide; Katano, Takahito; Hamano, Shingo; Nishiwaki, Hirotaka; Tsukamoto, Hironobu; Mizoshita, Tsutomu; Mori, Yoshinori; Kubota, Eiji; Tanida, Satoshi; Kataoka, Hiromi; Okuda, Noriaki; Joh, Takashi

doi:10.1155/2014/828137

Cited by 31 publications

(31 citation statements)

References 37 publications

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“…The updated systematic review and meta-analysis on fiber in IBS performed for this guideline identified 15 RCTs, involving 946 patients (58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72). Only one trial was at low risk of bias (70).…”

Section: Quality Of Evidence: Moderatementioning

confidence: 99%

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

Ford

Martin

Chey

et al. 2018

American Journal of Gastroenterology

276

396

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IntroductionIrritable bowel syndrome (IBS) is the most prevalent of the functional gastrointestinal disorders (FGIDs). Current estimates are that IBS affects up to 10-12% of adults in North America (1,2). Although it can affect all individuals regardless of age, creed, or gender, IBS is more common among women and is most commonly diagnosed in younger individuals (< age 50) (2, 3). IBS is characterized by recurrent abdominal pain and altered bowel habits; bloating and distention frequently coexist. The diagnosis of IBS is made by taking a careful history, eliciting key symptoms, as well as performing a physical examination and limited diagnostic testing (4-6). IBS is categorized into four main subtypes based on the predominant bowel habit: IBS with constipation (IBC-C); IBS with diarrhea (IBS-D); IBS with mixed symptomology (IBS-M); and unclassified IBS (5).IBS imposes a significant burden to the health care system and to individuals.Direct medical costs attributed to IBS in the US, excluding prescription and over-thecounter medicines, were estimated at $1.5-$10 billion per year in 2005 (7). Patients with IBS enrolled in a large Health Maintenance Organization (HMO) had significantly more outpatient visits and incurred nearly 50% more in total costs than individuals without IBS (8). A retrospective case-control study from another large HMO reported that patients with IBS had significantly more diagnostic tests, imaging, and surgery compared with patients without a diagnosis of IBS (9). Significant variations in care across the United States related to the diagnosis and treatment of IBS also play a role in excessive health care costs (10). The burden of IBS on individuals can be measured in a number of ways. Studies have demonstrated consistently that IBS impairs work-related activities (e.g., lost work time, reduced productivity while at work) and also reduces quality of life (11,12). The development Ford et al.Page 3 of 91 of effective and efficient treatment strategies for IBS assumes considerable importance, therefore, not just for the individual sufferer, but for society at large.Given the clinical heterogeneity that is a hallmark of the disorder and the absence of a single effective therapy for all sufferers, available therapies tend to focus on predominant symptomatology at presentation (i.e., altered bowel habits, abdominal pain, or bloating) (4-6). Based on their purported mode of action, many pharmacological therapies for IBS developed in recent decades have been directed towards those with a particular bowel habit, whether diarrhea or constipation.However, treating IBS patients can be difficult as no validated treatment algorithm exists, not all patients respond to treatment, and patients with similar symptoms frequently respond to the same treatment differently. Fortunately, a variety of novel therapeutic strategies are being explored and new compounds have appeared since the last iteration of the ACG monograph on IBS (4). The goal of this document, therefore, is to provide an updated, evidence-based d...

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Section: Quality Of Evidence: Moderatementioning

confidence: 99%

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

Ford

Martin

Chey

et al. 2018

American Journal of Gastroenterology

276

396

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“…It was also shown to have anti-inflammatory effects, with observed protective actions in acute liver injury in rats [29] and improvement effects on chronic rheumatism [30] and IBS [31] in humans.…”

Section: Discussionmentioning

confidence: 99%

Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis <i>in vitro</i> via VEGFR2 and its downstream signaling pathways

Zhu¹,

Okubo²,

Igari³

et al. 2017

Bioscience of Microbiota, Food and Health

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Angiogenesis is implicated in diverse pathological conditions such as cancer, rheumatoid arthritis, psoriasis, atherosclerosis, and retinal neovascularization. In the present study, we investigated the effects of modified rice bran hemicellulose (MRBH), a water-soluble hemicellulose preparation from rice bran treated with shiitake enzymes, on vascular endothelial growth factor (VEGF)-induced angiogenesis in vitro and its mechanism. We found that MRBH significantly inhibited VEGF-induced tube formation in human umbilical vein endothelial cells (HUVECs) co-cultured with human dermal fibroblasts. We also observed that MRBH dose-dependently suppressed the VEGF-induced proliferation and migration of HUVECs. Furthermore, examination of the anti-angiogenic mechanism indicated that MRBH reduced not only VEGF-induced activation of VEGF receptor 2 but also of the downstream signaling proteins Akt, extracellular signal-regulated protein kinase 1/2, and p38 mitogen-activated protein kinase. These findings suggest that MRBH has in vitro anti-angiogenic effects that are partially mediated through the inhibition of VEGF signaling.

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“…; Kamiya et al . ). Phenolic compounds show great potential to treat cancer and prevent oxidation in our body (Huang et al .…”

Section: Introductionmentioning

confidence: 97%

“…Rice bran is also beneficial to lower the blood cholesterol level, blood glucose level and blood pressure (Prasad et al 2011). Moreover, such bran serves as anticancer, anti-aging and anti-inflammatory agents as it is a rich source of phenolic antioxidants (Prasad et al 2011;Esa et al 2013;Kamiya et al 2014). Phenolic compounds show great potential to treat cancer and prevent oxidation in our body (Huang et al 2010).…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD System-Based Phenolic Content Analysis andIn VitroAntioxidant Activities of Rice Bran Obtained from Aush Dhan (Oryza Sativa) of Bangladesh

Reza

Gias

Islam

et al. 2015

Journal of Food Biochemistry

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Food fibers are recently gaining interest in the scientific community for their beneficial role in various diseases such as diabetes, cardiovascular diseases, cancer and neurodegenerative diseases. Rice bran is an important source of food fibers. The objective of this study was to determine the presence of polyphenolic compounds in rice bran of Aush Dhan and determine the in vitro antioxidant activities in different extracts such as ethanol, ethylacetate and toluene extracts. Various antioxidant assays, including DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging, nitric oxide scavenging, hydrogen peroxide, reducing power, total phenolic content and total flavonoid content, were studied. Moreover, high-performance liquid chromatography (HPLC) was used to identify and quantify the phenolic compounds. The extracts showed effective DPPH free radical, hydrogen peroxide radical and nitric oxide scavenging activities. However, reducing power was not significant compared with the standard antioxidant ascorbic acid. Phytochemical analysis shows that rice bran contains reducing sugar, flavonoids and tannins. Furthermore, high-performance liquid chromatography coupled with photodiode array detector (HPLC-DAD) analysis showed that rice bran contains high amount of rutin hydrate along with epicatechin, which are strong natural antioxidants. These results suggest that rice bran contains high amount of antioxidants, which may be used as a source of polyphenolic compounds and can be used to treat chronic disease.

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Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study

Cited by 31 publications

References 37 publications

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome

Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis <i>in vitro</i> via VEGFR2 and its downstream signaling pathways

HPLC-DAD System-Based Phenolic Content Analysis andIn VitroAntioxidant Activities of Rice Bran Obtained from Aush Dhan (Oryza Sativa) of Bangladesh

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