Therapeutic effects of 5-ALA-induced photodynamic therapy in vulvar lichen sclerosus

Inflammatory Linear Verrucous Epidermal Nevus Successfully Treated with Methyl-Aminolevulinate Photodynamic Therapy

“…21 Biniszkiewicz and colleagues treated 24 patients with lichen sclerosus, and symptoms resolved in 78.1% of them after 4 weeks. 22 One patient diagnosed with cutaneous sarcoidosis was successfully treated with PDT. The lesions were refractory to different approaches, including topical and systemic corticosteroids, cryotherapy, clofazimine, allopurinol, and psoralen and long-wave ultraviolet radiation therapy.…”

Photodynamic therapy as a therapeutic alternative in vulvar lichen sclerosus: series of 8 cases

“…No clinical benefit has been proved with topical administration of progesterone and testosterone (1). Photodynamic therapy has been described in the literature as an effective therapeutic alternative in vulvar LS in adult women, with significant improvement in both clinical appearance and quality of life (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). This work shows our experience with 8 patients with severe vulvar lichen sclerosus et atrophicus undergoing photodynamic therapy using methyl aminolevulinate and 635-nm light.…”

Clinical Trials and Basic Research in Photodynamic Diagnostics and Therapies from the Center for Laser Diagnostics and Therapy in Poland

“…In 17 patients, the itching ceased completely; in six women itching decreased, and for one patient, the itching continued; none of the patients presented exacerbation of itching. PDD after completion of therapy revealed normal green fluorescence of vulva in 10 patients and in 14 women pathological, red fluorescence, usually fainter than before PDT (58).…”