Photodynamic therapy as a therapeutic alternative in vulvar lichen sclerosus: series of 8 cases

Imbernón-Moya, Adrián; Martínez-Pérez, Marcela; Churruca-Grijelmo, Micaela; Lobato‐Berezo, Alejandro; Vargas-Laguna, Elena; Fernández-Cogolludo, Eva; Aguilar-Martínez, Antonio; Gallego-Valdés, Miguel Ángel

doi:10.1111/phpp.12242

Cited by 11 publications

(10 citation statements)

References 14 publications

(12 reference statements)

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“…Sotiriou et al [21] treated five patients with recalcitrant vulvar lichen sclerosis with ALA-PDT with a single session and reported complete alleviation of symptoms sustained over 3 months, but again with only minor improvement in the appearance of the vulval lesions. Imbernón-Moya et al [22] used PDT to treat eight patients with vulvar lichen sclerosus. All patients could tolerate the treatments.…”

Section: Discussionmentioning

confidence: 99%

5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases

Lan

Zou

Hamblin

et al. 2018

Photodiagnosis and Photodynamic Therapy

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Section: Discussionmentioning

confidence: 99%

5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases

Lan

Zou

Hamblin

et al. 2018

Photodiagnosis and Photodynamic Therapy

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“…In addition, some investigators used 5-ALA with the addition of dimethyl sulfoxide (DMSO) at a concentration of 2% or 20% ( n = 4), mainly due to the increased efficacy of the treatments resulting from the higher penetration of 5-ALA into deeper skin layers [ 36 , 37 , 40 , 45 ]. Methyl aminolevulinate (MAL) was employed in two studies [ 30 , 34 ]. The duration of the maintenance of the photosensitizer on the skin ranged from 115 min to 6 h, with a clear dominance of the 3-h period ( n = 11).…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen studies have described the efficacy of PDT in the resolution of pruritus. The considerable reduction of itching as measured by VAS or VRS scales was reported in eight publications [ 28 , 29 , 31 , 34 , 35 , 38 , 40 , 41 ]. Other studies indicated high therapeutic efficacy of PDT in relieving pruritus, in some cases of a gradual nature with subsequent treatments [ 27 , 30 , 32 , 33 , 37 , 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…Sotiriou et al described a mediocre improvement in terms of clinical signs (hyperkeratosis, atrophy, induration, depigmentation) in 9/10 women receiving PDT and a complete lack of improvement in 1/10 patients [ 28 ]. In addition, Imbernón-Moya demonstrated that the evaluation of VLS lesions regarding clinical and morphological aspects was similar before and after PDT [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

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Photodynamic Therapy in the Treatment of Vulvar Lichen Sclerosus: A Systematic Review of the Literature

Gerkowicz

Szczepanik-Kułak

Krasowska

2021

JCM

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Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease involving the genital skin and mucous membrane. Patients exhibit focal atrophy and destructive scarring, with an increased risk of malignant transformation. Due to objective symptoms as well as subjective complaints, patients with VLS experience emotional distress, lowered mood, and sexual dysfunction, which is reflected in impaired health-related quality of life. Thus, the necessity of implementing appropriate therapy at the earliest possible stage of the disease in order to avoid serious complications is highlighted. We presented the systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, and Web of Science databases. We identified a total of twenty relevant studies which indicate that photodynamic therapy (PDT) is a valuable therapeutic modality in the treatment of VLS.

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“…Further data are provided by some noncomparative studies including prospective cohorts and case series [199][200][201][202][203][204][205][206][207]. The majority of the patients included in these studies were treated with 5-ALA before the application of radiation (5-ALA PDT), whereas the remaining patients with methyl-aminolevulinate (methyl-PDT).…”

Section: Photodynamic Therapymentioning

confidence: 99%

Vulvar Lichen Sclerosus from Pathophysiology to Therapeutic Approaches: Evidence and Prospects

et al. 2021

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Vulvar lichen sclerosus (VLS) is a chronic, distressing, inflammatory disease with an enormous impact on quality of life. Treatment goals are relieving symptoms, reversing signs and preventing anatomical changes. Despite the availability of numerous therapeutic options, treatment outcome may not be entirely satisfactory and a definitive cure does not exist. This may be due to the fact that the exact VLS etiopathogenesis remains unknown. The objectives of this paper were to review the most up-to-date knowledge on VLS etiopathogenesis and to consider the available therapies through the lens of a plausible pathogenetic model. An electronic search on both VLS etiopathogenesis and its treatment was performed using the National Library of Medicine PubMed database. Based on current knowledge, it is conceivable that various, heterogeneous environmental factors acting on a genetic background trigger an autoimmune, Th-1 response, which leads to a chronic inflammatory state. This, in turn, can determine both tissue and micro-vascular injury and activation of signaling pathways involved in fibroblast and collagen metabolism. This pathogenetic sequence may explain the effectiveness of anti-inflammatory treatments, mostly topical corticosteroids, in improving VLS clinical-pathological changes. Further deepening of the disease pathways will presumably allow key mediators to become new therapeutic targets and optimize the available treatments.

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Photodynamic therapy as a therapeutic alternative in vulvar lichen sclerosus: series of 8 cases

Cited by 11 publications

References 14 publications

5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases

5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases

Photodynamic Therapy in the Treatment of Vulvar Lichen Sclerosus: A Systematic Review of the Literature

Vulvar Lichen Sclerosus from Pathophysiology to Therapeutic Approaches: Evidence and Prospects

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