5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases

Lan, Ting; Zou, Yongzhen; Hamblin, Michael R.; Yin, Rui

doi:10.1016/j.pdpdt.2017.12.003

Cited by 25 publications

(10 citation statements)

References 22 publications

(32 reference statements)

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“…In a study performed on ten patients with refractory vulvar LS, nine out of ten patients reported improved clinical response and complete disappearance of itching and one patient reported decrease of itching from severe to mild. Side effects were pain, swelling and erythema and were tolerable (107). Another study performed on 102 patients with vulvar LS treated with ALA-PDT weekly for ten weeks found complete and partial response in 87.25% of patients, the greatest response being observed in the reduction of subepithelial ecchymoses and telangiectasia (108).…”

Section: Updates In Pdt For Lichen Sclerosus -A Dermatosis With Potenmentioning

confidence: 96%

Photodynamic therapy: A hot topic in dermato-oncology (Review)

et al. 2019

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Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Data available so far indicate that PDT is a promising treatment method which can be successfully employed in several medical fields including dermatology, urology, ophthalmology, pneumology, cardiology, dentistry and immunology. Numerous authors therefore have studied this technique in order to improve its efficacy. As a result, significant advancement has been achieved with regard to PSs and drug delivery systems. Substantial progress was also obtained with respect to PDT for the treatment of precancerous skin lesions, several authors focusing their efforts on the study of daylight-PDT and on identifying methods of decreasing technique-related pain. This review reports on the most recent findings in PDT, with emphasis on cutaneous precancerous lesions. Contents 1. Introduction 2. Photodynamic therapy-generalities 3. Updates in PDT components 4. Updates in PDT for the management of actinic keratoses 5. Updates in PDT for Bowen's disease and erythroplasia of Queyrat 6. Updates in PDT in the treatment of other precancerous skin lesions: Actinic cheilitis and keratoacanthoma 7. Updates in PDT for lichen sclerosus-a dermatosis with potential for malignant transformation 8. Discussion

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Section: Updates In Pdt For Lichen Sclerosus -A Dermatosis With Potenmentioning

confidence: 96%

Photodynamic therapy: A hot topic in dermato-oncology (Review)

et al. 2019

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“…Photodynamic therapy (PDT) with the use of topical 10% 5-ALA cream (5-aminolaevulinic acid) has been found to be useful in treating VLS [ 32 ]. In a study, after application of freshly prepared 10% 5-ALA cream with a one-cm margin and incubating for three hours, the lesions were irradiated with 100 J/cm 2 633 nm red light at 100 mW/cm 2 [ 33 ]. The same PDT procedure was repeated three times at two-week intervals.…”

Section: Reviewmentioning

confidence: 99%

Treatment Options in Vulvar Lichen Sclerosus: A Scoping Review

Singh¹,

Mishra²,

Ghatage³

2021

Cureus

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Vulvar lichen sclerosus (VLS) is a chronic inflammatory disorder, which affects women of all ages. The aim of this review is to focus on first-line, second-line, and maintenance therapies as well as follow-up of women with VLS. With numerous controversies, we decided to conduct a scoping review on this subject. A review protocol was developed, and the Knowledge Resource Services website was used to run a search of articles pertaining to VLS with keywords "Vulvar," "Vulval," and "Lichen Sclerosus." The search was limited to published data from the last 10 years, i.e., July 2009 onward, and researches published in English language. A total of 338 articles pertaining to VLS were obtained. Out of this, 62 were original articles related to management of VLS. Effective treatments such as high-potency topical steroids are now the standard of care and first-line treatment. Follow-up may be done every three to six months for the first two years and then at least yearly to ensure adequacy of treatment and encourage compliance. Long-term follow-up in specialist clinics is recommended for women who have persistent complaints, thickened skin, or history of neoplastic lesion. Monitoring young patients yearly is recommended as there are chances of recurrence.

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“…Sixteen studies have described the efficacy of PDT in the resolution of pruritus. The considerable reduction of itching as measured by VAS or VRS scales was reported in eight publications [ 28 , 29 , 31 , 34 , 35 , 38 , 40 , 41 ]. Other studies indicated high therapeutic efficacy of PDT in relieving pruritus, in some cases of a gradual nature with subsequent treatments [ 27 , 30 , 32 , 33 , 37 , 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Photodynamic Therapy in the Treatment of Vulvar Lichen Sclerosus: A Systematic Review of the Literature

Gerkowicz

Szczepanik-Kułak

Krasowska

2021

JCM

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Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease involving the genital skin and mucous membrane. Patients exhibit focal atrophy and destructive scarring, with an increased risk of malignant transformation. Due to objective symptoms as well as subjective complaints, patients with VLS experience emotional distress, lowered mood, and sexual dysfunction, which is reflected in impaired health-related quality of life. Thus, the necessity of implementing appropriate therapy at the earliest possible stage of the disease in order to avoid serious complications is highlighted. We presented the systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, and Web of Science databases. We identified a total of twenty relevant studies which indicate that photodynamic therapy (PDT) is a valuable therapeutic modality in the treatment of VLS.

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5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: Series of ten cases

Abstract: ALA-PDT is an effective and safe approach for the treatment of VLSA.

Cited by 25 publications

References 22 publications

Photodynamic therapy: A hot topic in dermato-oncology (Review)

Photodynamic therapy: A hot topic in dermato-oncology (Review)

Treatment Options in Vulvar Lichen Sclerosus: A Scoping Review

Photodynamic Therapy in the Treatment of Vulvar Lichen Sclerosus: A Systematic Review of the Literature

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