Photodynamic therapy: A hot topic in dermato-oncology (Review)

Tampa, Mircea; Sârbu, Maria Isabela; Matei, Clara; Mitran, Cristina-Iulia; Mitran, Madalina-Irina; Căruntu, Constantin; Constantin, Carolina; Neagu, Monica; Georgescu, Simona Roxana

doi:10.3892/ol.2019.9939

Cited by 51 publications

(58 citation statements)

References 99 publications

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“…10). After absorbing light, this photosensitizer produces ROS, leading to apoptosis, necrosis, autophagy, inflammation and a systemic immune response against tumor tissues (212–214). This ROS‐based tumor destruction mechanism is similar to the mechanism of action of widely used chemotherapeutics such as bleomycin (215).…”

Section: Prevention and Treatment Of Nonmelanoma Skin Cancermentioning

confidence: 99%

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer

Lee

Ratnakumar

Hung

et al. 2020

Photochem & Photobiology

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Ultraviolet (UV) radiation is among the most prevalent environmental factors that influence human health and disease. Even 1 h of UV irradiation extensively damages the genome. To cope with resulting deleterious DNA lesions, cells activate a multitude of DNA damage response pathways, including DNA repair. Strikingly, UV‐induced DNA damage formation and repair are affected by chromatin state. When cells enter S phase with these lesions, a distinct mutation signature is created via error‐prone translesion synthesis. Chronic UV exposure leads to high mutation burden in skin and consequently the development of skin cancer, the most common cancer in the United States. Intriguingly, UV‐induced oxidative stress has opposing effects on carcinogenesis. Elucidating the molecular mechanisms of UV‐induced DNA damage responses will be useful for preventing and treating skin cancer with greater precision. Excitingly, recent studies have uncovered substantial depth of novel findings regarding the molecular and cellular consequences of UV irradiation. In this review, we will discuss updated mechanisms of UV‐induced DNA damage responses including the ATR pathway, which maintains genome integrity following UV irradiation. We will also present current strategies for preventing and treating nonmelanoma skin cancer, including ATR pathway inhibition for prevention and photodynamic therapy for treatment.

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Section: Prevention and Treatment Of Nonmelanoma Skin Cancermentioning

confidence: 99%

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer

Lee

Ratnakumar

Hung

et al. 2020

Photochem & Photobiology

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“…PDT can be regarded as a particular form of photochemotherapy, based on a photochemical reaction, which uses a photosensitizer, a source of light and oxygen, exerting a selective cytotoxic effect (35,36). The activation of the photosensitizer by light results in the generation of reactive oxygen species, especially singlet oxygen, leading to tissue necrosis and apoptosis (37,38).…”

Section: Photodynamic Therapya Promising Therapymentioning

confidence: 99%

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Tocut¹,

Mitran²,

Mitran³

et al. 2019

JMMS

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Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity and genetic predisposition). The therapeutic approach should take into account the type of lesion and the extent of the disease, as well as the possible adverse effects. Although several therapies are available, OLP treatment still remains a challenge. Photodynamic therapy (PDT) is widely used in dermatology, finding applicability in the treatment of an increasing number of conditions. Recent research has shown the role of PDT in the treatment of OLP. It is a minimally invasive therapy with few side effects and promising results. Keywords  oral lichen planus, photosensitizer, therapy Highlights  The therapeutic approach in the OLP remains a challenge; although many therapies are available, none of them can still be considered the ideal therapeutic approach.  PDT seems to be a promising therapy, but with heterogeneous results due to lack of standardization (the available studies using different sources of light, wavelengths and photosensitizers).

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“…Its use for treatment of age-related macular degeneration (3)(4)(5), actinic keratosis (6,7), esophageal cancers (8,9), and non-small cell lung cancer (10,11) has been approved by the FDA. The use of PDT in pre-clinical studies and clinical trials for skin (12)(13)(14), bladder (15), prostate (16), brain (17,18), and head and neck cancers (19)(20)(21)(22), as well as malignant mesothelioma (23)(24)(25) and gynecologic disease (26) have been reported. In contrast with chemotherapy, PDT is a highly localized treatment technique that can spare healthy cells.…”

Section: Introductionmentioning

confidence: 99%

Light Sources and Dosimetry Techniques for Photodynamic Therapy

Kim

Darafsheh

2020

Photochem & Photobiology

225

180

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Effective treatment delivery in photodynamic therapy (PDT) requires coordination of the light source, the photosensitizer, and the delivery device appropriate to the target tissue. Lasers, light‐emitting diodes (LEDs), and lamps are the main types of light sources utilized for PDT applications. The choice of light source depends on the target location, photosensitizer used, and light dose to be delivered. Geometry of minimally accessible areas also plays a role in deciding light applicator type. Typically, optical fiber‐based devices are used to deliver the treatment light close to the target. The optical properties of tissue also affect the distribution of the treatment light. Treatment light undergoes scattering and absorption in tissue. Most tissue will scatter light, but highly pigmented areas will absorb light, especially at short wavelengths. This review will summarize the basic physics of light sources, and describe methods for determining the dose delivered to the patient.

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Photodynamic therapy: A hot topic in dermato-oncology (Review)

Cited by 51 publications

References 99 publications

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Light Sources and Dosimetry Techniques for Photodynamic Therapy

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