Therapeutic effect of the preparation Aqua Maris® Ectoin in patients with allergic intermittent rhinitis

Mokronosova, M A; Mechnikov, Moscow Serums named after I. I.; Zheltikova, T. M.; Aref’eva, A. S.; Tarasova, G D

doi:10.18692/1810-4800-2017-2-142-148

Cited by 1 publication

(8 citation statements)

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“…Consequently, summary scores were calculated differently. Several trials applied additional methods, such as rhinocytogram, rhinoscopy, or eosinophil counting [ 44 , 45 ].…”

Section: Methodsmentioning

confidence: 99%

“…Only 3 of the selected studies applied a randomization [ 43 , 46 , 50 ], whereas 3 did not carry out randomization due to local regulatory restrictions [ 47 , 49 ]. Two studies were single-arm trials [ 44 , 45 ], and the remaining studies did not present any information regarding randomization.…”

Section: Methodsmentioning

confidence: 99%

“…(b) Application of ENS alone compared to other therapies or placebo [43,47,49,55] (Table 3) (c) Application of ENS only without comparator [44,45,48,54] (Table 4)…”

Section: Efficacy and Effectiveness Of Ectoine Nasalmentioning

confidence: 99%

“…Given that INS are the most efficacious pharmacological treatment for allergic rhinoconjunctivitis [30], it is not surprising that the effectiveness of ENS alone, which still showed an impressive >50% symptom improvement, does not match up to that of INS. Mokronosova et al showed in 2 studies that treatment for 14 days with ENS resulted in successful treatment of 58.8% and >90% of patients, respectively [44,45]. According to Abdulkerimov et al [46], significant nasal symptom relief was evident within 18 to 21 days in moderate-to-severe rhinitis patients who underwent treatment with ENS.…”

Section: Monotherapy With Ectoinementioning

confidence: 99%

“…Intranasal corticosteroids (INS) (mometasone, fluticasone, beclomethasone) [46][47][48] Oral or local antihistamine or local cromoglicate [49,50] Standard of care (guideline conform use of antihistamine and cromoglicate) [51][52][53] Intranasal isotonic salt solution [43,54,55] Only 3 of the selected studies applied a randomization [43,46,50], whereas 3 did not carry out randomization due to local regulatory restrictions [47,49]. Two studies were single-arm trials [44,45], and the remaining studies did not present any information regarding randomization.…”

mentioning

confidence: 99%

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The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis

Bilstein¹,

Werkhäuser

Rybachuk

et al. 2021

BioMed Research International

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Nonpharmacological therapies with a good tolerability and safety profile are of interest to many patients with allergic rhinitis, as a relevant proportion of them have reservations about guideline-concordant pharmacological therapies due to their local irritations and side effects. Ectoine is a bacterial-derived extremolyte with an ability to protect proteins and biological membranes against damage caused by extreme conditions of salinity, drought, irradiation, pH, and temperature. Evidence from preclinical and clinical studies attests its effectiveness in the treatment of several inflammatory diseases, including allergic rhinitis. In this review, we analyzed 14 recent clinical trials investigating ectoine nasal spray in patients with allergic rhinitis and/or conjunctivitis, including sensitive patient groups like children or pregnant women. Some studies investigated monotherapy with ectoine; others investigated combination therapy of ectoine and an antihistamine or a corticosteroid. Analysis of the study results demonstrated that patients with mild-to-moderate symptoms of allergic rhinitis can be successfully treated with ectoine-containing nasal spray. When applied as monotherapy, ectoine exerted noninferior effects compared to first-line therapies such as antihistamines and cromoglicic acid. Using ectoine as an add-on therapy to antihistamines or intranasal glucocorticosteroids accelerated symptom relief by days and improved the level of symptom relief. Importantly, concomitant treatment with ectoine was proven beneficial in a group of difficult-to-treat patients suffering from moderate-to-severe rhinitis symptoms. Taken together, the natural substance ectoine represents a viable alternative for allergic rhinitis and conjunctivitis patients who wish to avoid local reactions and side effects associated with pharmacological therapies.

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“…Consequently, summary scores were calculated differently. Several trials applied additional methods, such as rhinocytogram, rhinoscopy, or eosinophil counting [ 44 , 45 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…(b) Application of ENS alone compared to other therapies or placebo [43,47,49,55] (Table 3) (c) Application of ENS only without comparator [44,45,48,54] (Table 4)…”

Section: Efficacy and Effectiveness Of Ectoine Nasalmentioning

confidence: 99%