Therapeutic effect of prolonged hyperbaric oxygen in adjuvant arthritis of the rat

Abstract

Development of adjuvant disease in the rat is suppressed if hyperbaric oxygen is administered within one day after the inoculation of an oil suspension of Mycobacterium tuberculosis and continued for 16 to 17 days. Although 10 to 40% of the rodents developed mild arthritis after discontinuance of therapy, most remained symptom-free for at least 50 days. Oxygen administered after arthritis is advanced still exerted a significant curative effect. Possible mechanisms underlying the therapeutic action of oxygen are discussed.Prolonged exposure of rodents to hyperbaric oxygen (HBO) will suppress experimental autoimmune disease and block the delayed hypersensitivity reaction (DHR) to several antigens. Adjuvant disease in the rat (AD), a systemic, immune disorder induced by exogenous antigen and a useful model for the development of anti-arthritic drugs, is also modified by HBO. Fischer 344 rats were exposed to oxygen at 2 atmospheres absolute (15 psi) for 6 hours daily beginning at various times after their sensitization with Mycobacterium tuberculosis

Human Amniotic Fluid Mesenchymal Stem Cells in Combination with Hyperbaric Oxygen Augment Peripheral Nerve Regeneration

“…One study used HBO at 2.4 ATA and 100% oxygen, which is equivalent to diclofenac 20 mg/kg [35]. HBO has also been shown to decrease the symptoms of advanced arthritis in rats [36], and it attenuated the inflammatory response in the peritoneal cavity caused by injected meconium [37]. In addition, one study using HBO at 2.5 ATA showed increased survival and decreased proteinuria, anti-dsDNA antibody titers, and immune-complex deposition in lupusprone autoimmune mice [38].…”

Hyperbaric oxygen therapy may improve symptoms in autistic children

“…HBOT has also been shown to decrease the symptoms of advanced arthritis in rats [96] and attenuates the inflammatory response in the peritoneal cavity caused by injected meconium [97]. In addition, one animal study using HBOT at 2.5 ATA showed increased survival and decreased proteinuria, anti-dsDNA antibody titers, and immune-complex deposition in lupus-prone autoimmune mice [98].…”

Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain

“…Experimentally, HBO 2 treatment can reduce allodynia in rats with peripheral nerve injuries (Thompson et al, 2010; Li et al, 2011; Gu et al, 2012; Zhang et al, 2012) and experimental arthritis (Warren et al, 1979; Wilson et al, 2006, 2007). Research from our laboratory demonstrated that HBO 2 treatment effectively reduces pain in animal models of acute pain (Ohgami et al, 2009; Zelinski et al, 2009a; Chung et al, 2010; Quock et al, 2011).…”