Therapeutic effect of phenolic compounds isolated from Rhododendron ungernii leaves

Abstract

The sum of phenolic compounds was obtained from the leaves of Caucasian endemic plant Rhododendron ungernii (Trautv.) in the amount of 7%. The extract contains flavonoids, catechins, and anthocyanidins, in particular, quercetin, isoquercetin, quercitrin, hyperin, rutin, (+)-catechin, (-)-epicatechin, (+)-gallocatechin, and leucoanthocyanidins. The sum of phenolic compounds from Rhododendron ungernii completely inhibits Herpes simplex virus reproduction in a bioassay. A new medicinal preparation (Rhodopes) in the form of a 5% ointment was created on the basis of this extract and tested under clinical conditions at a dental clinic and three other specialized medical departments. The results showed a high therapeutic efficacy: Rhodopes favorably influenced the state of patients and caused neither mucosa irritation nor allergic and other adverse reactions. Rhodopes has received State Registration and is recommended for the treatment of all forms of herpetic disorders.

Anti–Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of Quercus brantii L Acorn

“… 47 The flavonoid fraction was shown to be effective against both HSV-1 and HSV-2 with inhibitory effect on replication cycle of HSV-1. 48 , 49 Therefore, in consistent with these findings, our results might indicate that promising anti-HSV-1 activity of chloroform fraction could be attributed to its flavonoid content.…”

Antiherpetic activity of a flavonoid fraction from Ocotea notata leaves

“…For instance, afzelin, quercitrin and kaempferol showed anti-HSV-1 activity (Almeida et al, 1998;Lyu et al, 2005) whereas quercetin and isoquercitrin showed activity against both HSV-1 and HSV-2 (Chiang et al, 2003;Gomes et al, 2008). A medicinal preparation from the plant extract Rhododendron ungernii containing the flavonoids quercetin, isoquercitrin, quercitrin, (+)-catechin, (-)-epicatechin and others received the approval from the Georgia government to treat HSV-1 disorders in the oral cavity (Kemertelidze et al, 2007).…”

Isolation of phenolic constituents from Rhododendron yunnanense flowers as a potent cyclooxygenase-2 and vascular endothelial growth factor receptor-2 inhibitor: Phytochemical and molecular simulation studies

“…One-dimensional and two-dimensional NMR together were used for structural elucidation of the isolated compounds and in comparison, with previously reported spectral data. Accordingly, the isolated compounds were identified as quercetin (1) (Jaiswal et al, 2012, Jaiswal et al, 2014, quercitrin (2) (Dai andYu, 2005, Jaiswal et al, 2012), avicularin (3) (Manivannan and Shopna, 2015), taxifolin-3-O-β-L-arabinoside (4) (Jin et al, 2009), azalein (5) (Hang et al, 2011), kaempferol-3-O-α-L-rhamnoside (6), kaempferol-4ʹ-methoxy-3-O-α-L-rhamnoside (7) (Jaiswal et al, 2014), kaempferol-3-O-α-D-glucoside (8) (Hong et al, 2007, Jaiswal et al, 2014, catechin (9) (Jaiswal et al, 2012;Jin et al, 2009), epicatechin (10) (Jaiswal et al, 2012), catechin gallate (11) (Jaiswal et al, 2012;Kemertelidze et al, 2007), 5-O-p-transcoumaroylquinic acid methyl ester (12) (Jaiswal et al, 2011), and 5-O-caffeoylquinic acid methyl ester (13) (Jaiswal et al, 2011). The data of the isolated compounds are listed in detail in the experimental section.…”