Isolation of phenolic constituents from Rhododendron yunnanense flowers as a potent cyclooxygenase-2 and vascular endothelial growth factor receptor-2 inhibitor: Phytochemical and molecular simulation studies

Abdelkader, Mohamed Salaheldin A.; Abdelhamid, Reda A.; Abouelela, Mohamed E.; Rateb, Mostafa E.; Hassan, Marwa H. A.

doi:10.7324/japs.2021.1101112

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Consequently, the isolated and identified compounds (Fig. 1) were kaempferol (1) (Wu et al, 2012), ethyl gallate (2) (Ooshiro et al, 2009), gallic acid (3) (López-Martínez et al, 2015), kaempferol-3-Oβ-D-glucoside "astragalin" (4) (Abdelkader et al, 2021;Ghareeb et al, 2018), astragalin-6″-gallate (5) (Nugroho et al, 2014), kaempferol-3-O-rutinoside "nicotiflorin" (6) (Orhan et al, 2007), ellagic acid (7) (Ghareeb et al, 2018) , and 1,2,3,4,6-pentagalloylglucose (8) (Deiab et al, 2015). The isolated compounds' NMR spectra are provided in the supplementary file section.…”

Section: Identification Of Isolated Compoundsmentioning

confidence: 99%

Colorectal cytotoxic activities of phenolic constituents isolated from Euphorbia pseudocactus cultivated in Egypt

Ismail¹,

Hassan²,

Zaki³

et al. 2022

J App Pharm Sc

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Phytochemical investigation of the ethyl acetate fraction of the Euphorbia pseudocactus aerial parts, family Euphorbiaceae, resulted in the isolation of eight phenolic compounds for the first time from this species. Identification was carried out using different chromatographic and spectroscopic techniques. The isolated compounds were kaempferol (1), ethyl gallate (2), gallic acid (3), astragalin (4), astragalin-6″-gallate (5), nicotiflorin (6), ellagic acid (7), and 1,2,3,4,6-pentagalloylglucose (8). The colorectal cytotoxic activity of the isolated phenolic compounds against the LS-174T and LS-513 (cecum) cell lines was tested using the sulforhodamine B assay. The results revealed that gallic acid possessed colorectal cytotoxic activity with IC 50 values of 18.27 and 50.11 µg/ml against the LS-174T and LS-513 cell lines, respectively, while ethyl gallate possessed cytotoxic activity with IC 50 value of 25.42 µg/ml against the LS-174T cell line. The results of the other phenolic compounds showed nonsignificant anticancer activity. These findings recommend gallic acid as an anticancer lead compound.

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Section: Identification Of Isolated Compoundsmentioning

confidence: 99%

Colorectal cytotoxic activities of phenolic constituents isolated from Euphorbia pseudocactus cultivated in Egypt

Ismail¹,

Hassan²,

Zaki³

et al. 2022

J App Pharm Sc

View full text Add to dashboard Cite

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Ceiba pentandra ethyl acetate extract improves doxorubicin antitumor outcomes against chemically induced liver cancer in rat model: a study supported by UHPLC-Q-TOF-MS/MS identification of the bioactive phytomolecules

Orabi,

Abouelela,

Darwish

et al. 2024

Front. Pharmacol.

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Hepatocellular carcinoma (HCC) is a prevalent cancer worldwide. Late-stage detection, ineffective treatments, and tumor recurrence contribute to the low survival rate of the HCC. Conventional chemotherapeutic drugs, like doxorubicin (DOX), are associated with severe side effects, limited effectiveness, and tumor resistance. To improve therapeutic outcomes and minimize these drawbacks, combination therapy with natural drugs is being researched. Herein, we assessed the antitumor efficacy of Ceiba pentandra ethyl acetate extract alone and in combination with DOX against diethylnitrosamine (DENA)-induced HCC in rats. Our in vivo study significantly revealed improvement in the liver-function biochemical markers (ALT, AST, GGT, and ALP), the tumor marker (AFP-L3), and the histopathological features of the treated groups. A UHPLC-Q-TOF-MS/MS analysis of the Ceiba pentandra ethyl acetate extract enabled the identification of fifty phytomolecules. Among these are the dietary flavonoids known to have anticancer, anti-inflammatory, and antioxidant qualities: protocatechuic acid, procyanidin B2, epicatechin, rutin, quercitrin, quercetin, kaempferol, naringenin, and apigenin. Our findings highlight C. pentandra as an affordable source of phytochemicals with possible chemosensitizing effects, which could be an intriguing candidate for the development of liver cancer therapy, particularly in combination with chemotherapeutic drugs.

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Isolation of phenolic constituents from Rhododendron yunnanense flowers as a potent cyclooxygenase-2 and vascular endothelial growth factor receptor-2 inhibitor: Phytochemical and molecular simulation studies

Cited by 2 publications

References 33 publications

Colorectal cytotoxic activities of phenolic constituents isolated from Euphorbia pseudocactus cultivated in Egypt

Colorectal cytotoxic activities of phenolic constituents isolated from Euphorbia pseudocactus cultivated in Egypt

Ceiba pentandra ethyl acetate extract improves doxorubicin antitumor outcomes against chemically induced liver cancer in rat model: a study supported by UHPLC-Q-TOF-MS/MS identification of the bioactive phytomolecules

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