Therapeutic effect of ferulic acid, an ethereal fraction of ethanolic of seed of Syzygium cumini against streptozotocin-induced diabetes in male rat

Abstract

Diabetic therapeutic and antioxidative effects of an ethereal fraction of the ethanolic extract of the seed of Syzygium cumini was studied in streptozotocin (STZ)-induced diabetic rats. Diabetes resulted in a significant elevation in the fasting blood glucose level and in the activity of hepatic glucose-6-phosphatase. There was diminution in the levels of glycogen in the liver and skeletal muscle along with diminution in the activities of hepatic glucose-6-phosphate dehydrogenase, catalase and peroxidase in diabetic rats when compared with controls. Hepatic levels of thiobarbituric acid reactive substance (TBARS) and conjugated dienes (CD) were elevated in respect to control. Oral coadministration of the above fraction to diabetic rats resulted in significant protection in all these parameters. Histological studies of the pancreas showed a qualitative diminution in the area and volume of the islet's of Langerhans, but coadministration of the specific fraction resulted in a significant recovery of the islet's of Langerhans. Chromatography study revealed that the used fraction was ferulic acid (FA). Treatment with FA in normoglycemic rats did not show any significant change in the levels of the selected biosensors. The possible hypothesis for the therapeutic effect of FA against diabetes may be due to its pancreatic beta-cell regenerative effect and/or due to its antioxidant properties.

Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate

“…Ferulate is known to have anti-diabetic, antithrombotic, anti-inflammatory, anticancer, and antiaging effects (Barone et al 2009;Mandal et al 2008). In most studies, ferulate has been explored largely as an antioxidant based on its phenolic structure, through which it scavenges free radicals by its hydroxyl and phenoxy groups that readily donate electrons (Graf 1992;Kanski et al 2002).…”

Bioavailability of hydroxycinnamates: a brief review of in vivo and in vitro studies

“…In this regard, HC have been shown to inhibit the oxidation of lipids in vitro (Nardini et al 1995;Castelluccio et al 1996;Bourne and Rice-Evans 1997;Andreasen et al 2001c) and of DNA in vivo (Maurya and Nair 2006). These may be the underlying mechanisms for preventing bacterial mutagenesis in vitro (Ferguson et al 2003), TPA-dependent tumor promotion in mouse (Huang et al 1988), 4-nitroquinoline-1-oxideinduced tongue carcinogenesis (Tanaka et al 1993), and streptozotocin-induced diabetes in rats (Balasubashini et al 2004;Ohnishi et al 2004;Mandal et al 2008).…”

Effect of Rosmarinus Officinalis on Lipid Profile of Streptozotocin-Induced Diabetic Rats

“…Glycemic control manifested by serum glucose and HbA1c was better in treated STZ-induced diabetic groups compared to untreated STZ-induced diabetics, which may suggest either sparing of more panctreatic islet cells with treatment, enhanced insulin sensitivity or insulinlike action of the dried rosemary leaves powder. The significant decrease of HbA1c in treated STZ-induced diabetic groups can be attributed to amelioration of hyperglycemia as well as the free radical scavenging activity of active components of the dried rosemary leaves powder (Mandal et al, 2008).…”