Effect of Rosmarinus Officinalis on Lipid Profile of Streptozotocin-Induced Diabetic Rats

Soliman, Ghada A.

doi:10.5171/2013.118807

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Also, the use of RO facilitates the bile flow and reduces the liver enzymes; therefore, it is used as a hepatoprotective agent and choleretic in traditional medicine (Tai et al, 2012, Rašković et al, 2014, Al-Sereiti et al, 1999. Moreover, several studies have been reported anti-diabetic (Soliman, 2013), anti-inflammatory (Mengoni et al, 2011), antioxidant (Selmi et al, 2017), renal protective (Azab et al, 2014) and hepatoprotective (Sotelo-Felix et al, 2002, Amin andHamza, 2005) properties of this plant. According to available reports, the most antioxidant compounds of RO are carnosicacid and carnosol (Gutiérrez et al, 2010).…”

Section: Introductionmentioning

confidence: 89%

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

2020

THE JAPS

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Section: Introductionmentioning

confidence: 89%

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

2020

THE JAPS

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“…The animals were housed individually in stainless steel cages in a controlled environment (25 ± 2°C, 50–60% relative humidity, and 12-hour light-dark cycle), and the experiment lasted for 8 weeks. The animals had ad libitum access to food and deionized water and were subdivided into five groups (7 rats each) as follows: group 1: control negative (C−) was fed standard balanced diet AIN-93G with normal calcium level (0.5% w/w) according to formula described by Reeves et al [22]; group 2: control positive (C+) was fed balanced diet with low calcium level (L Ca) (Ca 0.1% w/w) according to Shinoki and Hara [23]; group 3: thyme (T) was given L Ca diet and treated with thyme power (5% w/w) [24]; group 4: rosemary (R) was given L Ca diet and treated with rosemary power (5% w/w) [25]; group 5: oral calcium (O) was orally administered with CaCO3 (27 mg/kg b.w.) and fed L Ca diet [26].…”

Section: Methodsmentioning

confidence: 99%

The Impact of Thyme and Rosemary on Prevention of Osteoporosis in Rats

Elbahnasawy

Valeeva

El-Sayed

et al. 2019

Journal of Nutrition and Metabolism

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Osteoporosis poses an important public health problem which affects millions of people worldwide. There is a direct link between calcium deficiency in diet and induction of osteoporosis and bone loss. The current study was conducted to evaluate the protective effect of thyme (Thymus vulgaris L.) and rosemary (Rosmarinus officinalis L.) against osteoporosis in rats with low calcium intake. Essential oils of rosemary and thyme were analyzed. The experiment was carried out on growing male Sprague–Dawley rats; the experimental animals were divided into 5 groups: 1, control negative was fed standard balanced diet; 2, control positive was fed balanced diet with low calcium level (L Ca) (Ca 0.1% w/w); 3, (L Ca) + thyme powder (5% w/w); 4, (L Ca) + rosemary powder (5% w/w); 5, (L Ca) + orally administration with CaCO3 (27 mg/kg body weight). Blood samples were collected for different biochemical analyses in plasma (calcium (Ca), phosphorus (P), magnesium (Mg), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), malondialdehyde (MDA), parathyroid hormone (PTH), C-terminal telopeptide (CTX), and 1,25-(OH)2-vitamin D3). Femur mass, length, and bone mineral density (BMD) were recorded, and histopathological studies for femurs were examined. Low-calcium diet induced osteoporotic changes in positive control rats (decrease in Ca, vitamin D3, and BMD and increase in CTX, PTH, TNF-α, CRP, and MDA). Supplementation with thyme and rosemary inhibited significantly the development of bone loss, increased Ca and vitamin D3 in plasma, improved BMD, and also prevented the inflammation and oxidative stress (improved TNF-α, CRP and MDA) compared to the positive control. The histopathological examination of treated groups showed an improvement in bone histology and protection against bone loss. However, thyme powder showed more effective impact than rosemary. Our study demonstrates that thyme and rosemary effectively mitigated calcium deficiency-induced bone loss and maybe considered as promising candidates for preventing bone resorption and osteoporosis.

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“…Furthermore, administration of aqueous RE (200 mg/kg/day) for four weeks prior and to streptozotocin injection in rats significantly protected against STZ-induced elevations in blood glucose levels which was correlated with a significant protection against pancreatic β-cell loss [ 54 ] In addition, RE increased serum insulin, C-peptide while decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Administration of dried rosemary leaves (5 g/100 g of diet) for approximately six weeks in STZ-induced diabetic and healthy Sprague-Dawley rats decreased the FPG, glycated hemoglobin (HbA1c), TC and TG and LDL levels in STZ- induced rats without effecting the plasma glucose levels or the lipid profile in the control group [ 55 ]. Oral administration of RE (200 mg/kg/day) with or without moderate intensity exercise training for eight weeks resulted in reduction of FPG and increased serum insulin levels in STZ-induced diabetic rats [ 56 ].…”

Section: Streptozotocin (Stz)-induced Diabetes Modelmentioning

confidence: 99%

Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

et al. 2017

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Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods of prevention and treatments for insulin resistance and T2DM are lacking in number and efficacy and, therefore, there is a need for new preventative measures and targeted therapies. In recent years, chemicals found in plants/herbs have attracted attention for their use as functional foods or nutraceuticals for preventing and treating insulin resistance and T2DM. Rosemary is an evergreen shrub indigenous to the Mediterranean region and South America, which contains various polyphenols. Rosemary extract and its polyphenolic constituents have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-hyperglycemic properties. The current review summarizes the existing in vitro and in vivo studies examining the anti-diabetic effects of rosemary extract and its polyphenolic components and highlights the known mechanism of action.

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Effect of Rosmarinus Officinalis on Lipid Profile of Streptozotocin-Induced Diabetic Rats

Cited by 6 publications

References 19 publications

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

Comparative Physiological Response of Sainfoin (Onobrychis Viciaefolia) Seedlings to Alkaline and Saline-Alkaline Stress

The Impact of Thyme and Rosemary on Prevention of Osteoporosis in Rats

Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

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