Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

Naimi, Madina; Vlavcheski, Filip; Shamshoum, Hesham; Tsiani, Evangelia

doi:10.3390/nu9090968

Cited by 92 publications

(64 citation statements)

References 67 publications

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“…In addition, as has being described by various researchers, rosmarinic and chlorogenic acid act as strong antioxidants and hypoglycemic agents [48][49][50][51][52]. Thus, the antioxidant and enzyme inhibition activity of the plant, can be explained due to the properties of the above-mentioned compounds, in combination to the presence of the other identified compounds.…”

Section: Resultsmentioning

confidence: 86%

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

et al. 2019

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Ziziphora is a plant used in Turkish and Iran traditional medicine for its antibacterial activity, sedative and stomach soothing properties. Although the chemical profile of the essential oil of different Ziziphora species is well documented, data regarding plant extracts are incomplete. In this study extracts from Ziziphora taurica subsp. cleonioides were obtained using ethyl acetate, methanol and water and the chemical profile of the aerial part of the plant was elucidated. Among the compounds identified, rosmarinic acid was the most abundant (3375.67 ± 38.02 μg/mL), at the extract of methanol, followed by chlorogenic acid (3225.10 ± 16.44). Enzyme inhibition activity against α-amylase and tyrosinase was also estimated. The ethyl acetate extract showed the highest α-amylase activity (1.95 ± 0.04 mg/mL), while the best anti-tyrosinase activity was calculated for the methanolic extract (1.25 ± 0.01 mg/mL). In addition, total phenolic, flavonoid content and antioxidant activity were evaluated. According to our results, bioactivity of the plant is of great interest, nonetheless, at the same time, it is strongly depended on the solvent used during the extraction process. Our data suggest that the plant under study may be an important source to consider against metabolic, skin pigmentation and oxidative stress related disorders.

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Section: Resultsmentioning

confidence: 86%

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

et al. 2019

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“…However, it is difficult to determine the exact role of individual food components in disease prevention. Specific food components, polyphenols, have continued to gain attention within the scientific community for their potential health benefits and preventive and therapeutic properties against chronic diseases [12,13,[18][19][20][21].…”

Section: Glucose Homeostasis: Role Of Insulinmentioning

confidence: 99%

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approaches to prevent and manage/treat the disease better. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (I of II) summarizes the existing in vitro studies examining the antidiabetic effects of curcumin, while a second (II of II) review summarizes evidence from existing in vivo animal studies and clinical trials focusing on curcumin’s antidiabetic properties.

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“…However, it is difficult to determine the role of food components in disease prevention and treatment. Specific components, known as polyphenols, have gained attention within the scientific community for their potential health benefits and preventative and therapeutic properties against chronic diseases [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

2019

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment approaches to insulin resistance and T2DM lack in efficacy, resulting in the need for new approaches to prevent and treat the disease. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects, including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (II of II) summarizes the existing in vivo studies examining the antidiabetic effects of curcumin.

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Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives

Cited by 92 publications

References 67 publications

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

Study on the Chemical Composition, Enzyme Inhibition and Antioxidant Activity of Ziziphora taurica subsp. cleonioides

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

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