Therapeutic drug monitoring and measurement of drug concentrations using mass spectrometry

Telekes, András; Hegedüs, Márta; Kiss, István

doi:10.1016/b978-044451980-1.50015-x

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“…Percutaneous penetration measurements are performed in vivo in animal models or humans since they are dependent on blood circulation. Drug concentrations are usually measured by high-performance liquid chromatography (HPLC) or mass spectrometry [4]. Proton nuclear magnetic resonance (1H NMR) spectroscopy allows the characterisation of the most represented proton-containing low-molecular-mass compounds in a biological sample and their representation in a spectrum [5].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Psoriasis: Novel Approaches to Topical Delivery

Wollina¹,

Tirant²,

Vojvodić³

et al. 2019

Open Access Maced J Med Sci

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Topical treatment is the cornerstone for the management of mild to moderate psoriasis. Despite efforts in drug development, patient's satisfaction with the available topical treatments is limited. A strategy to improve safety, efficacy and comfort of topical treatment provides the development of new drug delivery and drug carrier systems. This review provides an overview of recent advances in this field with a focus on psoriasis. Laser-assisted drug delivery, foam formulations, nanoparticles, ethosomes, and niomes are considered. Hopefully, these new developments will improve topical drug therapy and patient satisfaction.

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Section: Introductionmentioning

confidence: 99%