Therapeutic Dosage in Small and Large Mammals

Abstract

Now available in this country, the outstanding SP.500 uv and visible range spectrophotometer. Try it. The first thing you'll notice is that the controls are mounted on a sloping panel -only Unicam can be operated accurately and comfortably by a seated operator. Saves fatigue, permits continuous operation.Turn on the instrument. Notice how the dials and other controls move precisely, smoothly through their cycles, giving the operator a sense of confidence. The heart of a high-quality spectrophotometer is an efficient monochromator. Check Unicam's! See how it combines excellent transmission characteristics, and narrow spectral bandwidth with a minimum of stray light. See how the universal cell housing focuses the light beam precisely for microcell workanother exclusive feature. But don't stop with the operation. Lift the cover. See the neatly soldered controls, the precision workmanship throughout. Note the convenient dual source housingstandard equipment on Unicam. The prism is of fused silica, another major improvement to extend the working range to 186 mu.We'll place a Unicam SP.500 in your laboratory on trial so you can prove its many advantages on both routine and special analytical work. Before you spend money on a spectrophotometer, see how much more you get with a Unicam, at lower cost. Write, wire or phone for a Unicam SP.500 trial without cost or obligation. Visit Booths 16 and 73 at the Pittsburgh ConferenceNow available in this country, the outstanding SP.500 uv and visible range spectrophotometer. Try it. The first thing you'll notice is that the controls are mounted on a sloping panel -only Unicam can be operated accurately and comfortably by a seated operator. Saves fatigue, permits continuous operation.Turn on the instrument. Notice how the dials and other controls move precisely, smoothly through their cycles, giving the operator a sense of confidence. The heart of a high-quality spectrophotometer is an efficient monochromator. Check Unicam's! See how it combines excellent transmission characteristics, and narrow spectral bandwidth with a minimum of stray light. See how the universal cell housing focuses the light beam precisely for microcell workanother exclusive feature. But don't stop with the operation. Lift the cover. See the neatly soldered controls, the precision workmanship throughout. Note the convenient dual source housingstandard equipment onUnicam. The prism is of fused silica, another major improvement to extend the working range to 186 mu.We'll place a Unicam SP.500 in your laboratory on trial so you can prove its many advantages on both routine and special analytical work. Before you spend money on a spectrophotometer, see how much more you get with a Unicam, at lower cost. Write, wire or phone for a Unicam SP.500 trial without cost or obligation. Visit Booths 16 and 73 at the Pittsburgh ConferenceNow available in this country, the outstanding SP.500 uv and visible range spectrophotometer. Try it. The first thing you'll notice is that the controls are mounted on a sloping panel -only...

Scaling toxicity data across species

“…The elephant immediately went into convulsions and died within 2 hours. Harwood (1963) pointed out that the outcome might have been different if body surface area scaling had been used.…”

LSD-induced effects in elephants: Comparisons with musth behavior

“…At least 1 week separated test doses. There was no apparent reaction to total doses of .0 25 or .100 mg. A dose of .300 rng, suggested by Harwood (1963), also failed to elicit observable responses. Doses of 1.0 mg administered orally or via intramuscular injection produced only mild restlessness and increased rocking and swaying.…”

“…Treatment with promazine (2 ,800 mg) and pentobarbital was followedby death at 100 min post LSD. The results failed to provide clear evidence of musth-like behavior, and the study has been the subject of controversy and criticism regarding issues of miscalculation of dosage (Harwood, 1963;Hoffer & Osmond, 1967) and toxicity of LSD independent of the other drugs (Witt, 1975) . Because the original study has continued to receive attention and criticism (e.g., Jentzsch, 1983), the following study was conducted to correct procedural problems and reexamine the relationship between LSD and musth behavior in the elephant.…”

Neonatal Exposure to Fenoterol and Betamethasone: Effects on the Behavioral Development in the Rat

“…To promote fetal lung maturation, BET is recommended at a dosage level of 12 mg given twice in 24 hr to the pregnant woman (NIH, 1995). A therapeutic dose for a 250-g rat on the basis of a human weight equivalent for surface area (Harwood, 1963) would be twice 1.1 mg/kg. In rats, a sufficient surfactant-inducing effect has indeed been observed at dosage levels of 1 mg/kg applied at gestational days 16 and 17 (Pfannschmidt et al, 1983) or gestational days 18 and 19 (Moya et al, 1992), respectively.…”