Therapeutic aspect of microRNA inhibition in various types of hypertension and hypertensive complications

Preethi, K. Auxzilia; Selvakumar, Sushmaa Chandralekha; Ross, Kehinde; Sekar, Durairaj

doi:10.1016/j.genrep.2022.101676

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…MicroRNA (miRNA) is a non-coding small fragment (approximately 20–22 nucleotides) single-stranded RNA molecule participating in various physiological processes in cells. , MiRNA let-7 is one of the earliest discovered miRNA families with 13 members in humans of which the miRNA let-7a is the earliest identified oncogene fragment . Numerous pathological studies have shown that the abnormal expression of miRNA let-7a in tumor cells and serum is correlated to many cancers, such as hepatocellular carcinoma (HCC), breast cancer, and pancreatic cancer, making miRNA let-7a one of crucial cancer biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Specific Adsorption of Magnetic Fe₃O₄@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Chen

Yang

et al. 2023

ACS Appl. Nano Mater.

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The unique discriminating ability of hydroxyapatite (HAP) to single- and double-stranded nucleic acid implies its potential as a biosensing material for nucleic acid analysis. Herein, a novel immobilization- and label-free electrochemical strategy has been developed for miRNA let-7a detection based on the specific adsorption of magnetic Fe3O4@hydroxyapatite (Fe3O4@HAP) to a duplex structure. Typically, the highly efficient homogeneous reaction between probe DNA (pDNA) and target miRNA let-7a produces the nucleic acid duplex, which is specifically adsorbed on the surface of Fe3O4@HAP. Thereafter, the electroactive intercalator Nile blue (NB) is introduced as the label-free signal molecule and inserts between the stacked base pairs of the pDNA–miRNA duplex. Thus, the Fe3O4@HAP bearing pDNA–miRNA and numerous intercalated NBs are adsorbed by the magnetic glassy carbon electrode, giving rise to an intense sensing signal without the need of nuclease-assisted cyclic amplification. With this advantage, the sensing system shows a wide linear range from 1.0 fM to 100 nM and a low detection limit of 0.051 fM for miRNA let-7a analysis. What is more, the synergy of the base-pairing-driven hybridization, the specific intercalation of NB to the duplex structure, and the selective adsorption of Fe3O4@HAP contribute to a high sensing specificity of the biosensing strategy. The sensing method provides a state-of-the-art strategy for the sensitive and facile bioanalysis and clinical diagnosis of miRNA.

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Section: Introductionmentioning

confidence: 99%

Specific Adsorption of Magnetic Fe₃O₄@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Chen

Yang

et al. 2023

ACS Appl. Nano Mater.

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“…A hipertensão é uma das principais causas de doenças cardiovasculares e renais, e prevê-se que até 2025, cerca de 25% dos adultos em todo mundo serão hipertensos (PREETHI et al, 2022). Apesar da ampla variedade de medicamentos anti-hipertensivos, apenas 21% dos indivíduos submetidos a essa terapia farmacológica terão a pressão arterial devidamente controlada (LOBO, ADEYEYE, KAPIL., 2022).…”

Section: Introductionunclassified

Influência Da Magnetita Incorporada Ao Óxido De Grafeno Na Adsorção De Furosemida

VARGAS¹,

ZANCANARO²,

NUNES³

et al. 2022

Anais Do Simpósio De Ensino, Pesquisa E Extensão (SEPE 2022)

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A utilização de medicamentos cresce exponencialmente no mundo e, por vezes, devido ao seu metabolismo incompleto, essas subtâncias como a furosemida são excretadas na sua forma inalterada. As técnicas convencionais de tratamento de efluentes atualmente empregadas mostram-se ineficientes à remoção deste microcontaminante, permitindo que retorne ao consumo. Assim, a adsorção utilizando nanomateriais, como o óxido de grafeno (GO) , mostra-se uma alternativa à remoção desse poluente aquático. A incorporação de nanopartículas magnéticas na estrutura do GO possibilita eliminar etapas, como centrifugação e filtração, necessárias para adsorventes convencionais. Tendo em vista as excelentes propriedades do adsorvente mencionado, o presente trabalho visa realizar um estudo de adsorção para a remoção de furosemida, utilizando GO e GO magnético (GO•Fe3O4) com diferentes proporções de magnetita incorporada.

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Non-Coding RNAs and Diet

Selvakumar,

Preethi,

Thomas

et al. 2024

Epigenetics and Human Health

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Therapeutic aspect of microRNA inhibition in various types of hypertension and hypertensive complications

Cited by 3 publications

References 68 publications

Specific Adsorption of Magnetic Fe₃O₄@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Specific Adsorption of Magnetic Fe₃O₄@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Influência Da Magnetita Incorporada Ao Óxido De Grafeno Na Adsorção De Furosemida

Non-Coding RNAs and Diet

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Therapeutic aspect of microRNA inhibition in various types of hypertension and hypertensive complications

Cited by 3 publications

References 68 publications

Specific Adsorption of Magnetic Fe3O4@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Specific Adsorption of Magnetic Fe3O4@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Influência Da Magnetita Incorporada Ao Óxido De Grafeno Na Adsorção De Furosemida

Non-Coding RNAs and Diet

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Product

Resources

About

Specific Adsorption of Magnetic Fe₃O₄@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA

Specific Adsorption of Magnetic Fe₃O₄@hydroxyapatite Nanocomposites to a Hybridized Duplex for Immobilization and Label-Free Electrochemical Biosensing of MicroRNA