Therapeutic applications of polarized light: Tissue healing and immunomodulatory effects

Feehan, Jack; Burrows, Soraya Patricia; Cornelius, Leonardo; Cook, Alyse Malietzis; Mikkelsen, Kathleen; Apostolopoulos, Vasso; Husaric, Maja; Kiatos, Dimitrios

doi:10.1016/j.maturitas.2018.07.009

Cited by 26 publications

(12 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study demonstrates that PLT can exert a measurable effect on the human immune system, giving much needed mechanistic evidence for its clinical effects. While phototherapies such as low‐level laser have been previously shown to have a suppressive effect on inflammation and immune response , very limited evidence exists investigating whether PLT has the same capacity. The results of this study demonstrate changes in gene expression and cell surface marker expression in differentiated U937 cells following 6 hours exposure of PL.…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of nonpharmacological anti‐inflammatory treatments is a key, but relatively underrepresented part of this process. A small but growing body of evidence indicates that phototherapies such as polarized light therapy (PLT) are a promising avenue of exploration in this area .…”

Section: Introductionmentioning

confidence: 99%

“…Preliminary clinical evidence indicates efficacy in the management of skin ulcers , burns , musculoskeletal injuries as well as surgical and nonhealing wounds . Despite this, there are little scientific data regarding the physiological mechanisms underlying these changes in vitro or in vivo . It has suggested that the interactions of light with the key mitochondrial enzyme cytochrome oxidase C are responsible for the beneficial changes observed in LLLT ; however, little information has been documented exploring the mechanisms of PLT.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects

Feehan

Tripodi

Fraser

et al. 2019

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

This study investigates the immunomodulatory effects of polychromatic polarized light therapy (PLT) on human monocyte cells. While there is some evidence demonstrating a clinical effect in the treatment of certain conditions, there is little research into its mechanism of action. Herein, U937 monocyte cells were cultured and exposed to PLT. The cells were then analyzed for change in expression of genes and cell surface markers relating to inflammation. It was noted that 6 hours of PLT reduced the expression of the CD14, MHC I and CD11b receptors, and increased the expression of CD86. It was also shown that PLT caused downregulation of the genes IL1B, CCL2, NLRP3 and NOD1, and upregulation of NFKBIA and TLR9. These findings imply that PLT has the capacity for immunomodulation in human immune cells, possibly exerting an anti‐inflammatory effect.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects

Feehan

Tripodi

Fraser

et al. 2019

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Polarized light in particular has been utilized for a number of clinical applications including wound healing [13] . Although its exact mechanism of action remains unknown, its advantageous effects over scattered light could be due to its higher capacity to penetrate skin, and thus to reach deeper tissues involved in wound healing.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent light energy in wound healing: when is a photon something more?

Zago

Dehghani

Jaworska

et al. 2020

Mechanisms of Photobiomodulation Therapy XV

View full text Add to dashboard Cite

Fluorescent Light Energy (FLE) is a unique form of photobiomodulation that stimulates healing, reduces inflammation, and alleviates pain. The system works by exciting a chromophore in a topical substrate, which emits FLE with a broad spectral range (~400-700 nm) that is delivered to the target tissue below. Results from in vivo and in vitro studies have shown FLE modulates inflammation via down-regulation of pro-inflammatory cytokines such as IL-6 and TNF-α, and stimulates mitochondria biogenesis 1. A recent study showed FLE-stimulated cells responded more potently compared to cells treated with light from an LED light source ("Mimicking Lamp") designed to generate the same emission spectra and power intensity profile as FLE 2. FLE-treated human dermal fibroblasts (HDF) experienced up-regulated collagen production, while a minor and nonsignificant effect was observed for the Mimicking Lamp-treated HDFs. These results suggest that photons generated by FLE either penetrate tissue differently or are absorbed differently compared to photons from a LED light source. Photonic properties of FLE that could impact tissue penetration or absorption may include polarity or coherency, leading to different cellular responses. To investigate if light polarity may influence cellular responses to FLE stimulation, the present study applied linear and circular-polarizing filters to investigate the influence of FLE's polarity on immune parameters. The data suggest that FLE polarity contributes to its impact on biological systems. Furthermore, the immunemodulatory impact of FLE was investgated in a pilot study on a human ex vivo skin model suggesting that central myeloid immune surface markes are modulated by FLE.

show abstract

“…Many studies reporting the effects of light therapy on humans, in different pathological conditions, concern the irradiation by the application of ultraviolet (UV) lamp [1,2], infrared (IR) laser [3,4], Light Emitting Diode (LED) [5,6], and Polarized Polychromatic Incoherent Low Energy Radiation (PILER) [7][8][9][10][11]. All these sources showed light therapy exerts reparative capacity by modulating the production of cytokines and other soluble factors, and their main targets are fibroblasts from the skin [7].…”

Section: Introductionmentioning

confidence: 99%

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Salmeri

Denaro

Ruello

et al. 2020

IJERPH

View full text Add to dashboard Cite

(1) Background: Physical stimuli may activate peripheral blood mononuclear cells (PBMCs) to secrete cytokines, which may favor pro-inflammatory responses or trigger reparative phenomena. The purpose of this study is to evaluate the action of Polarized Polychromatic Incoherent Low Energy Radiation (PILER) on human in vitro PBMCs, by detection of the possible effects on cytokine production; (2) Methods: isolated PBMCs were irradiated with a PILER lamp at different exposure times, at a distance of 10 cm, before incubation. The supernatants were collected after 24 h and 48 h and cytokines evaluated by ELISA; (3) Results: Our results showed a decrease in the levels of pro-inflammatory IL-12p70, IL-17A, IFN-γ, and TNF-α cytokines, whereas IL-10 and TGF-β1 with regulatory activity increased; (4) Conclusions: PILER irradiation affected the cytokine production by isolated PBMCs driving the immune response toward an anti-inflammatory/reparative profile.

show abstract

Therapeutic applications of polarized light: Tissue healing and immunomodulatory effects

Cited by 26 publications

References 34 publications

Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects

Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects

Fluorescent light energy in wound healing: when is a photon something more?

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Contact Info

Product

Resources

About