Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects

Abstract

This study investigates the immunomodulatory effects of polychromatic polarized light therapy (PLT) on human monocyte cells. While there is some evidence demonstrating a clinical effect in the treatment of certain conditions, there is little research into its mechanism of action. Herein, U937 monocyte cells were cultured and exposed to PLT. The cells were then analyzed for change in expression of genes and cell surface markers relating to inflammation. It was noted that 6 hours of PLT reduced the expression of the CD14, MHC I and CD11b receptors, and increased the expression of CD86. It was also shown that PLT caused downregulation of the genes IL1B, CCL2, NLRP3 and NOD1, and upregulation of NFKBIA and TLR9. These findings imply that PLT has the capacity for immunomodulation in human immune cells, possibly exerting an anti‐inflammatory effect.

Innovative Light Therapy: 3. Correction of the Acute Viral Respiratory Diseases Using Biophysical Capabilities of Bioptron-PILER-Light (Review)

“…The anti-inflammatory effect of PL is also confirmed by the results of a study of cultured human monocytes U937 that received a long exposure to PL [60]. The cells were then analyzed for change in expression of genes and cell surface markers relating to inflammation.…”

Treatment of Peri-Implant Mucositis with Standard of Care and Bioptron Hyperlight Therapy: A Randomized Clinical Trial

“…Bioptron light therapy system is a device with an optical unit emitting light that is similar to the sun, in terms of the electromagnetic spectrum produced, but without UV radiation. Bioptron irradiation increases the metabolism in human blood cells, affecting their cytokine production and driving the immune response towards an anti-inflammatory/reparative profile in addition to mitochondria activation and pain reduction [10,34,37]. These factors support the regenerative processes of irradiated tissues.…”

Phototherapy and Tailored Brushing Method. Personalized Oral Care in Patients with Facial and Dental Trauma. A Report of a Case

“…Bioptron light therapy system is a device with an optical unit emitting light that is similar to the sun in terms of the electromagnetic spectrum produced, but without UV radiation. Bioptron irradiation increases metabolism in human blood cells, affecting their cytokine production and driving the immune response towards an anti-inflammatory/reparative profile [ 25 ], in addition to mitochondria activation and pain reduction [ 16 , 27 , 28 ]. These factors support the regenerative processes of irradiated tissues.…”

“…Bioptron polarized light has been shown to be effective in microcirculation improvement [ 13 , 14 ], periodontal tissue regeneration, decrease in inflammation [ 15 , 16 ], and pain and stress relief, without any side-effects. Moreover, Bioptron Hyperlight Therapy has been used to implement the protocols of non-surgical periodontal therapy.…”