Therapeutic Apheresis: Why?

Malchesky, Paul S.

doi:10.1111/1744-9987.12353

Cited by 16 publications

(21 citation statements)

References 12 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After Malchesky, every effort should be made to delay the progression of chronic diseases. TA is clearly an important tool in treatment of many complex conditions now and in the future .…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Apheresis in Immunologic Renal and Neurological Diseases

Bambauer¹,

Latza²,

Burgard³

et al. 2017

Ther Apher Dial

View full text Add to dashboard Cite

Since the mid 1970s, when membrane modules became available, plasma separation techniques have gained in importance especially in the past few years. The advantages of this method are a complete separation of the corpuscular components from the plasma and due to increased blood flow rate and higher efficacy. Systemic autoimmune diseases based on an immune pathogenesis produce autoantibodies and circulating immune complexes, which cause inflammation in the tissues of various organs. In most cases, these diseases have a poor prognosis without treatment. Therapeutic apheresis (TA) in combination with immunosuppressive therapies has led to a steady increase in survival rates over the last 40 years. The updated information on immunology and molecular biology of different immunologic diseases are discussed in relation to the rationale for apheresis therapy and its place in combination with other modern treatments. The different diseases can be treated by various apheresis methods such as therapeutic plasma exchange (TPE) with substitution solution, or with online plasma or blood purification using adsorption columns, which contain biological or non-biological agents. Here, the authors provide an overview of the most important pathogenic aspects indicating that TA can be a supportive therapy in systemic autoimmune diseases such as renal and neurological disorders. For the immunological diseases that can be treated with TA, the guidelines of the German Working Group of Clinical Nephrology and of the Apheresis Committee of the American Society for Apheresis are cited.

show abstract

“…After Malchesky, every effort should be made to delay the progression of chronic diseases. TA is clearly an important tool in treatment of many complex conditions now and in the future .…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Apheresis in Immunologic Renal and Neurological Diseases

Bambauer¹,

Latza²,

Burgard³

et al. 2017

Ther Apher Dial

View full text Add to dashboard Cite

show abstract

“…Plasma exchange is currently used for therapeutic purposes in many immunological disorders. 3 Plasmapheresis generally is used when a toxic substance in the plasma, such as immunoglobulin, need to be effectively removed. Many well known inmmunological disorders that need plasmaphersis (including neurological disease MG, GBS etc, hematological disorders TTP, metabolic (Wilson disease), rheumatologic, dermatologic, renal diseases, and intoxications.…”

Section: Introductionmentioning

confidence: 99%

“…Many well known inmmunological disorders that need plasmaphersis (including neurological disease MG, GBS etc, hematological disorders TTP, metabolic (Wilson disease), rheumatologic, dermatologic, renal diseases, and intoxications. 3,4 There are many life style modifying disorders that require plasmapheresis as first-line therapy, or in conjunction with other treatment options (like thymectomy and use of steroids in many, or cytotoxic drugs) are as follows: GuillainBarre syndrome (GBS), Myasthenia gravis (MG), Thrombotic thrombocytopenic purpura (TTP) Hyperviscosity syndromes and Wilson disease etc. 5 Present study was conducted to determine the frequency of major indications require plasmapheresis in blood bank of Lady Reading …”

Section: Introductionmentioning

confidence: 99%

Plasmapheresis; An Experience in Blood Bank of a Tertiary Care Hospital in Peshawar

Qureshi

Khan

2017

TPMJ

View full text Add to dashboard Cite

ABSTRACT… Objectives:To determine the frequency of major indications require plasmapheresis in blood bank of Lady Reading Hospital Peshawar. Study Design: Cross sectional study. Setting: Blood bank of Lady Reading Hospital Peshawar. Period: June 2010 to June 2012. Material and methods: Relevant information's were recorded on a pre-designed questionnaire prepared in accordance with the objectives of the study. Results: A total of 54 patients were enrolled in the trial. 23 (42.59%) were females, and 31(57.41%) were males. Males to females ration was 1.4:1. We received patients for plasmaphersis in age ranging from 15 to 74 years. Majority were young patients in age range 15 to 34 years age. We received majority of the patients for the subject procedure from ICU (Intensive care unit) 20(73%), followed by cardiothoracic unit 17(31.48%). We also receive two volunteers during study. The frequency of various indications for plasmapheresis were; myasthenia gravis 29(53.7%), Guillen barre syndrome 20(37.04%) and thrombocytopenic purpura 3(5.56%). Conclusion. From this study we concluded that that autoimmune diseases are common in younger age which is a very serious concern for our society. Plasmapheresis is a therapeutic procedure as well and patients with autoimmune disorders get relieved with it symptomatically as autoimmune antibodies are removed. Myasthenia gravis was counted as major disease followed by GBS and thrombocytopenic purpura in our population. Key words:Autoimmune disorders, Plasmapheresis, Peshawar.

show abstract

“…I do not know anyone who would choose to be on dialysis or transplanted but we are very grateful to those researchers, developers, and clinicians who have provided these options as an alternative. In some nephrological diseases, their etiology is autoimmune‐ or immunological‐related . In some, such as rapidly progressing glomerulonephritis, Goodpasture’s, Henoch‐Schönlein purpura nephritis, focal segmental glomerulosclerosis, crescentric nephritis, lupus nephritis, ANCA‐associated glomerulonephritis, immune complex nephritis, and kidney transplantation rejection, there are biochemical factors present that accumulate or bind to the nephrons blocking the filtration processes of the kidneys.…”

mentioning

confidence: 99%

“…In some nephrological diseases, their etiology is autoimmune-or immunological-related. 10,11 In some, such as rapidly progressing glomerulonephritis, Goodpasture's, Henoch-Schönlein purpura nephritis, focal segmental glomerulosclerosis, crescentric nephritis, lupus nephritis, ANCA-associated glomerulonephritis, immune complex nephritis, and kidney transplantation rejection, there are biochemical factors present that accumulate or bind to the nephrons blocking the filtration processes of the kidneys. Treatment of these underlying causes before they become chronic can preserve function and actually prevent end-stage disease.…”

mentioning

confidence: 99%