Introduction: Chronic myelocytic leukemia (CML) is a slow growing disorder marked by excessive proliferation of cells of myeloid origin which do not lose their capacity to differentiate. Because of unavailability and un-affordability of such markers in most of our tertiary care centers, it is important to have a better understanding of clinical and hematological insight of this disease. Objective: To determine the clinical and hematological features of chronic myelocytic leukemia on bone marrow examination and trephine biopsy Material and method: The current study was cross-sectional study carried out at the Department of Hematology, Hayatabad medical complex, Peshawar from 8/4/2021 to 8/10/2021. In this study a total 196 patients were observed. The findings of bone marrow aspirate for morphology and phase of the disease, along with the trephine biopsy for bone marrow fibrosis were noted. All data with the demographic information like name, age, gender, occupation for further analysis were recorded. Results: In the current study, totally 196 patients were included. There were 112(57%) male patients and 84(43%) patients were female in our study. Based on clinical features and hematological features of patients with chronic myelocytic leukemia, 153(78%) patients had splenomegaly, 102(52%) patients had fever, 192(98%) patients had leukocytosis, 94(48%) patients had anemia. Conclusion: Our study concludes that the frequency of clinical and hematological features i.e. splenomegaly was 78%, fever was 52%, leukocytosis was 98%, anemia was 48% in patients presenting with chronic myelocytic leukemia. Keywords: clinical and hematological features, chronic myeloid leukemia.
ABSTRACT… Objectives:To determine the frequency of major indications require plasmapheresis in blood bank of Lady Reading Hospital Peshawar. Study Design: Cross sectional study. Setting: Blood bank of Lady Reading Hospital Peshawar. Period: June 2010 to June 2012. Material and methods: Relevant information's were recorded on a pre-designed questionnaire prepared in accordance with the objectives of the study. Results: A total of 54 patients were enrolled in the trial. 23 (42.59%) were females, and 31(57.41%) were males. Males to females ration was 1.4:1. We received patients for plasmaphersis in age ranging from 15 to 74 years. Majority were young patients in age range 15 to 34 years age. We received majority of the patients for the subject procedure from ICU (Intensive care unit) 20(73%), followed by cardiothoracic unit 17(31.48%). We also receive two volunteers during study. The frequency of various indications for plasmapheresis were; myasthenia gravis 29(53.7%), Guillen barre syndrome 20(37.04%) and thrombocytopenic purpura 3(5.56%). Conclusion. From this study we concluded that that autoimmune diseases are common in younger age which is a very serious concern for our society. Plasmapheresis is a therapeutic procedure as well and patients with autoimmune disorders get relieved with it symptomatically as autoimmune antibodies are removed. Myasthenia gravis was counted as major disease followed by GBS and thrombocytopenic purpura in our population. Key words:Autoimmune disorders, Plasmapheresis, Peshawar.
Objectives: To determine the frequency of major indications requireplasmapheresis in blood bank of Lady Reading Hospital Peshawar. Study Design: Crosssectional study. Setting: Blood bank of Lady Reading Hospital Peshawar. Period: June 2010to June 2012. Material and methods: Relevant information’s were recorded on a pre-designedquestionnaire prepared in accordance with the objectives of the study. Results: A total of 54patients were enrolled in the trial. 23 (42.59%) were females, and 31(57.41%) were males. Malesto females ration was 1.4:1. We received patients for plasmaphersis in age ranging from 15 to74 years. Majority were young patients in age range 15 to 34 years age. We received majorityof the patients for the subject procedure from ICU (Intensive care unit) 20(73%), followed bycardiothoracic unit 17(31.48%). We also receive two volunteers during study. The frequencyof various indications for plasmapheresis were; myasthenia gravis 29(53.7%), Guillen barresyndrome 20(37.04%) and thrombocytopenic purpura 3(5.56%). Conclusion. From thisstudy we concluded that that autoimmune diseases are common in younger age which is avery serious concern for our society. Plasmapheresis is a therapeutic procedure as well andpatients with autoimmune disorders get relieved with it symptomatically as autoimmuneantibodies are removed. Myasthenia gravis was counted as major disease followed by GBSand thrombocytopenic purpura in our population.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.