Therapeutic and Prophylactic Tools for Sporotrichosis: Current Strategies and Future Tendencies

Batista-Duharte, Alexander; Pereira, Sandro Antônio; Freitas, Dayvison Francis Saraiva; Fuentes, Deivys Portuondo; Gutierrez-Galhardo, Maria Clara; Carlos, Iracilda Zeppone

doi:10.1007/978-3-319-11912-0_9

Cited by 7 publications

(5 citation statements)

References 127 publications

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“…Ketoconazole Clinical studies on the use of ketoconazole for the treatment of feline sporotrichosis have shown varied results [ 78 , 85 , 135 , 136 , 137 , 138 , 139 , 140 ]. However, itraconazole has replaced ketoconazole due to its greater effectiveness and safety [ 85 , 141 ].…”

Section: Table A1mentioning

confidence: 99%

A One Health Approach to Combatting Sporothrix brasiliensis: Narrative Review of an Emerging Zoonotic Fungal Pathogen in South America

Rossow

Queiroz‐Telles

Cáceres

et al. 2020

JoF

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Cat-transmitted sporotrichosis caused by Sporothrix brasiliensis has become a major public health concern and presents a distinct divergence from the traditional epidemiology of sporotrichosis. This emerging fungal pathogen spreads readily among cat populations, and human infections occur exclusively via zoonotic transmission. While sporotrichosis is an implantation mycosis that typically manifests as cutaneous lesions in humans and cats, severe extracutaneous manifestations are more common with S. brasiliensis than other Sporothrix species infections. Rapid diagnosis and appropriate treatment regimens are critical for successful clinical resolution of sporotrichosis in both cats and humans. Species-level identification of Sporothrix is possible with molecular diagnostics and necessary for tracking the geographic expansion of S. brasiliensis and better understanding its epidemiology. Combatting cat-transmitted sporotrichosis requires a One Health approach to successfully implement public health control measures.

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Section: Table A1mentioning

confidence: 99%

A One Health Approach to Combatting Sporothrix brasiliensis: Narrative Review of an Emerging Zoonotic Fungal Pathogen in South America

Rossow

Queiroz‐Telles

Cáceres

et al. 2020

JoF

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“…Sporotrichosis can assume many clinical forms, including fixed cutaneous or lymphocutaneous and disseminated forms, the latter of which has been mainly reported in immunocompromised individuals [6,7]. Given the renewed epidemiological importance of sporotrichosis and difficulties associated with the conventional antifungal drugs, different strategies are being investigated for prevention and treatment of this disease [8,9].…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy and toxicity of two vaccine candidates against Sporothrix schenckii using either Montanide™ Pet Gel A or aluminum hydroxide adjuvants in mice

Portuondo

Batista-Duharte

Ferreira

et al. 2017

Vaccine

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Sporotrichosis is an important zoonosis in Brazil and the most frequent subcutaneous mycosis in Latin America, caused by different Sporothrix species. Currently, there is no effective vaccine available to prevent this disease. In this study, the efficacy and toxicity of the adjuvant Montanide™ Pet Gel A (PGA) formulated with S. schenckii cell wall proteins (ssCWP) was evaluated and compared with that of aluminum hydroxide (AH). Balb/c mice received two subcutaneous doses (1st and 14th days) of either the unadjuvanted or adjuvanted vaccine candidates. On the 21st day, anti-ssCWP antibody levels (ELISA), the phagocytic index, as well as the ex vivo release of IFN-γ, IL-4, and IL-17 by splenocytes and IL-12 by peritoneal macrophages were assessed. Cytotoxicity of the vaccine formulations was evaluated in vitro and by histopathological analysis of the inoculation site. Both adjuvanted vaccine formulations increased anti-ssCWP IgG, IgG1, IgG2a, and IgG3 levels, although IgG2a levels were higher in response to PGA+CWP100, probably contributing to the increase in S. schenckii yeast phagocytosis by macrophages in the opsonophagocytosis assay when using serum from PGA+CWP100-immunized mice. Immunization with AH+CWP100 led to a mixed Th1/Th2/Th17 ex vivo cytokine release profile, while PGA+CWP100 stimulated a preferential Th1/Th2 profile. Moreover, PGA+CWP100 was less cytotoxic in vitro, caused less local toxicity and led to a similar reduction in fungal load in the liver and spleen of S. schenckii- or S. brasiliensis-challenged mice as compared with AH+CWP100. These results suggest that PGA may be an effective and safe adjuvant for a future sporotrichosis vaccine.

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“…In this way, it was described that the exogenous supply of antioxidants, as natural compounds that scavenge free radicals, might represent an important additional tool for the treatment of opportunistic fungal infections during HIV infection (Otang et al, 2012). These findings suggest that the strategy associating immunomodulator/antinflammatory compounds with antifungal drugs seems to be promissory to improve the treatment efficacy in infections by S. schenckii (Guterres et al, 2014;Batista-Duharte et al, 2015.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii

Oliveira

Neto

et al. 2017

Journal of Ethnopharmacology

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Therapeutic and Prophylactic Tools for Sporotrichosis: Current Strategies and Future Tendencies

Cited by 7 publications

References 127 publications

A One Health Approach to Combatting Sporothrix brasiliensis: Narrative Review of an Emerging Zoonotic Fungal Pathogen in South America

A One Health Approach to Combatting Sporothrix brasiliensis: Narrative Review of an Emerging Zoonotic Fungal Pathogen in South America

Comparative efficacy and toxicity of two vaccine candidates against Sporothrix schenckii using either Montanide™ Pet Gel A or aluminum hydroxide adjuvants in mice

Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii

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