Therapeutic and fertility restoration effects of <i>Ionidium suffruticosum</i> on sub-fertile male albino Wistar rats: effects on testis and caudal spermatozoa

Chenniappan, Kuppusamy; Murugan, K

doi:10.1080/13880209.2016.1278453

Cited by 18 publications

(14 citation statements)

References 31 publications

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“…This finding concluded that Vitis vinifera possessed protective effects against reproductive toxicity. Ionidium suffruticosum (L.) Ging (Violaceae) is an ethnomedicinal herb widely used for treating jaundice, male sterility, diabetes, malaria, urinary tract infections, and water retention [ 60 ]. Carbendazim induced subfertile albino rats, treated with methanol extracts of Ionidium suffruticosum , showed an increase of sperm count, cauda epididymis sperm motility, body and testis weight, and germinal epithelial cell mass.…”

Section: Plant Extract and Infertilitymentioning

confidence: 99%

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, Angelica keiskei powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect.

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Section: Plant Extract and Infertilitymentioning

confidence: 99%

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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“…Sperm counts were evaluated according to an established method [ 26 ]. Semen obtained from cauda epididymides was diluted, thoroughly mixed, and transferred to a hemocytometer with a cover slip overlay.…”

Section: Methodsmentioning

confidence: 99%

Downregulation of DJ-1 Fails to Protect Mitochondrial Complex I Subunit NDUFS3 in the Testes and Contributes to the Asthenozoospermia

Wang

Sun

Zhao

et al. 2018

Mediators of Inflammation

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Asthenozoospermia (AS), an important cause of male infertility, is characterized by reduced sperm motility. Among the aetiologies of AS, inflammation seems to be the main cause. DJ-1, a conserved protein product of the PARK7 gene, is associated with male infertility and plays a role in oxidative stress and inflammation. Although our previous studies showed that a reduction in DJ-1 was accompanied by mitochondrial dysfunction in the sperm of patients with AS, the specific mechanism underlying this association remained unclear. In this study, we found that compared to the patients without AS, the expression of mitochondrial protein nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) Fe-S protein 3 (NDUFS3) was also significantly decreased in the sperm of patients with AS. Similarly, decreased expression of DJ-1 and NDUFS3 and reduced mitochondria complex I activity were evident in a rat model of AS. Moreover, we showed that the interaction between DJ-1 and NDUFS3 in rat testes was weakened by ORN treatment. These results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis.

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“…Diabetes have deleterious effect on male reproductive organs, OLE restored the weights of reproductive organs towards control level by its antioxidant activity, this was approved by the histopathology of testicular tissues of treated animals ( 28 ). L. suffruticosum leaf extract affect the testis as it increase the testicular weight, it also maintain normal pH in testicular microenvironment, it also increase the testicular oxidative biomarkers, SOD and CAT so lessen sperm agglutination ( 29 ).…”

Section: Effect Of Medicinal Herbs On Testismentioning

confidence: 99%

“…Sub-fertility was induced by carbendazim, the increase in cauda epididymal sperm counts is due to increased activity of acid and alkaline phosphatases and LDH of cauda epididymis, increased spermatogenesis by avoiding the sloughing off germ cells and by stimulating testosterone secretion. It also caused slight sperm agglutination due to the I. suffruticosum healing property on the epididymal epithelium, and regulation of epididymal cell protein secretion ( 29 ).…”

Section: Effect Of Medicinal Herbs On Epididymismentioning

confidence: 99%

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Effect of Herbal Medicine on Fertility Potential in Experimental Animals - an Update Review

Alahmadi

2020

Mater Sociomed

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Introduction: Sexual function greatly affects the quality of life. Any problem which affects satisfaction is considered sexual dysfunction. Aim: The aim of this study was to investigate how recently used of complementary and alternative medicines has increased in treating infertility. Methods: Study has descriptive character based on searched and analyzed facts from the published articles in scientific journals. Results: The majority of the studies done for the detection of the efficacy of medicinal plants in treating male infertility were done on experimental animals with few clinical studies. However, there is still a need for more studies to have certain results, as conflicting results were noted in different studies done on the effect of the same medicinal plant on spermatogenesis. It might be referred it to the absence of standardization among research models, the difference in extracts, administration route, doses and how long did the experiment last added to differences in the part of the plant used and plant collection. This review summarized the finding of many studies that studied the effect of different medicinal herbs on the testes, epididymis, sperm and prostate parameters, testosterone level and steroidogenesis, erection/ejaculation function and libido. Conclusion: The protective effect might be due to OLE competence to antagonize the oxidative stress and LPO. Londium suffruticosum I. suffruticosum leaf extract was administered to sub-fertile male rats, subfertility was induced by carbendazim, it resulted in increased spermatogenesis, increased sperm counts, lessened sperm agglutination by preserving normal pH in testicular microenvironment, increasing the testicular oxidative biomarkers, SOD, and CAT. It was found that the main active components of the extract are alkaloids, steroidal lactones and flavonoids.

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Therapeutic and fertility restoration effects of Ionidium suffruticosum on sub-fertile male albino Wistar rats: effects on testis and caudal spermatozoa

Cited by 18 publications

References 31 publications

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Downregulation of DJ-1 Fails to Protect Mitochondrial Complex I Subunit NDUFS3 in the Testes and Contributes to the Asthenozoospermia

Effect of Herbal Medicine on Fertility Potential in Experimental Animals - an Update Review

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