Therapeutic and diagnostic applications of dendrimers for cancer treatment☆

Wolinsky, Jesse B.; Grinstaff, Mark W.

doi:10.1016/j.addr.2008.02.012

Cited by 500 publications

(360 citation statements)

References 101 publications

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“…The higher the number of generations is the more terminal groups and bigger size the dendrimer has. The pharmacological and biomedical applicability of dendrimers has been extensively studied and reviewed lately, yet it is still a progressive field of research [1][2][3][4][5][6][7]. Dendrimers are ideal nanocarriers for drugs, because not only the drug itself, but also targeting and imaging molecules can be attached to the same macromolecule.…”

Section: Introductionmentioning

confidence: 99%

A mechanistic view of lipid membrane disrupting effect of PAMAM dendrimers

Berényi

Mihály

Wacha

et al. 2014

Colloids and Surfaces B: Biointerfaces

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The effect of 5 th generation polyamidoamine (PAMAM G5) dendrimers on multilamellar dipalmitoylphosphocholine (DPPC) vesicles was investigated. PAMAM was added in two different concentration to the lipids (10 -3 and 10 -2 dendrimer/lipid molar ratios). The thermal behavior of the evolved systems was characterized by DSC; while the structure and the morphology were investigated with small-and wide-angel X-ray scattering (SWAXS), freeze-fracture electron microscopy (FFTEM) and phosphorus-31 nuclear magnetic resonance ( 31 P-NMR) spectroscopy, respectively. IR spectroscopy was used to study the molecular interactions between PAMAM and DPPC. The obtained results show that the dendrimers added in 10 -3 molar ratio to the lipids generate minor perturbations in the multilamellar structure and thermal character of liposomes, while added in 10 -2 molar ratio dendrimers cause major disturbance in the vesicular system. The terminal amino groups of the dendrimers are in strong interaction with the phosphate headgroups and through this binding dendrimers disrupt the regular multilamellar structure of DPPC. Besides highly swollen, fragmented bilayers, small vesicles are formed.

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Section: Introductionmentioning

confidence: 99%

A mechanistic view of lipid membrane disrupting effect of PAMAM dendrimers

Berényi

Mihály

Wacha

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…Over the last several years, substantial progress has been made towards the therapeutic applications of dendrimers for cancer treatment (Wolinsky and Grinstaff, 2008); diverse dendrimers were used to increase the solubility of anticancer drugs, as well as to reduce drug toxicity. Recently, Hai et al (2011) have reported a PEGylated fourth generation PAMAM dendrimer as nanocarrier of the anticancer drug doxorubicin, encapsulated in the interior of PAMAM molecules; this study provides a potential application of this dendrimeric system for current brain cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers

Fernández

Sigal

Otero

et al. 2011

Braz. J. Chem. Eng.

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-The improvement of aqueous solubility of methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate, albendazole (ABZ) using polyamidoamine (PAMAM) dendrimers as solubility enhancers was investigated. Full generation PAMAM dendrimers with amine terminal groups, (G3), with hydroxyl terminal groups (G3OH) and half generation PAMAM dendrimers with carboxylate terminal groups (G2.5 and G3.5), were chosen for this study. The nature of dendrimer-ABZ association was investigated by UV absorption, fluorescence emission measurements and by 1 H-NMR spectroscopy. The results obtained show that these polymeric structures have the capacity to enhance the solubility of ABZ, both lipophilic and specific hydrogen bond interactions contributing to the guest-host association. Although all studied dendrimers have hydrophobic internal nanoenvironments with similar dimensions, their surfaces differ significantly and the nature and the localization of the interactions involved in ABZ-dendrimer association depend on the type of terminal groups.

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“…The prime example of this is seen in application of dendrimers. Dendrimers are circular designed nanoparticles that have been considered as a mean to administer medicinal agents for a variety of diseases [35]. A group of researchers developed a technique to attach tissue plasminogen activator (tPA) to dendrimers creating a drug delivery system which would necessitate lesser doses with reduced side effects.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…A group of scientists examined the dispersion of CNFs in PU with varying PU and CNF weight ratio to make an ideal bladder prosthetic material that should not only encourage usual chief human urothelial cell (HUC) purpose, but also hinder the reappearance of bladder cancerous cell action. The results were promising and delivered a new nano composite comprising of CNF and PU that should be considered for preventing the reoccurrence of cancerous bladder tissue and for encouraging usual non-cancerous bladder tissue development [30][31][32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%