Theranostic nanocomplex of gold-decorated upconversion nanoparticles for optical imaging and temperature-controlled photothermal therapy

Ramírez-García, Gonzalo; Honorato-Colin, Miguel Angel; Rosa, E. De la; López–Luke, Tzarara; Panikar, Sandeep Surendra; Ibarra-Sánchez, José de Jesús; Piazza, Valeria

doi:10.1016/j.jphotochem.2019.112053

Cited by 18 publications

(18 citation statements)

References 42 publications

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“…Therefore, it is important to detect the temperature in the tumor site during the PTT process to obtain the optimal treatment temperature at which the tumor can be completely eliminated while surrounding normal tissues are not damaged or only minimally damaged. Previous studies have shown that rare earth elements Yb 3+ and Er 3+ doped materials had fluorescence emission at 525 and 545 nm under 980-nm laser irradiation, which was linear correlated with temperature and might be used for temperature sensing (29)(30)(31)(32). However, these Yb 3+ and Er 3+ doped materials do not have photothermal property, and the light absorption under 980-nm irradiation is high in vivo by body fluids.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

et al. 2020

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Photothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.

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Section: Resultsmentioning

confidence: 99%

Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

et al. 2020

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“…NIR light-activated nanocomposites combining UCNPs with photothermal agents show great prospects in PTT of tumor 45 , 110 – 115 . Our group 44 reported multifunctional UCNPs@CS@Ag 2 Se nanocomposites for multi-modal imaging-guided PTT of tumor.…”

Section: Emerging Applications Of Ucnps-based Nanocompositesmentioning

confidence: 99%

Nanocomposites based on lanthanide-doped upconversion nanoparticles: diverse designs and applications

Feng

Gao

et al. 2022

Light Sci Appl

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Lanthanide-doped upconversion nanoparticles (UCNPs) have aroused extraordinary interest due to the unique physical and chemical properties. Combining UCNPs with other functional materials to construct nanocomposites and achieve synergistic effect abound recently, and the resulting nanocomposites have shown great potentials in various fields based on the specific design and components. This review presents a summary of diverse designs and synthesis strategies of UCNPs-based nanocomposites, including self-assembly, in-situ growth and epitaxial growth, as well as the emerging applications in bioimaging, cancer treatments, anti-counterfeiting, and photocatalytic fields. We then discuss the challenges, opportunities, and development tendency for developing UCNPs-based nanocomposites.

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“…It is also known that the peak optical absorption in AuNPs ranges from 510 to 550 nm in wavelength, and the spectral intensity depends on the number, shape, and dispersity of the particles. 20,30,31 In this experiment, although the purple colors of the liquid products were found at all pH conditions, the liquid product at pH 9.5 possessed the stronger purple color and the higher optical absorption than those produced at any other pH conditions. This indicates that the difference in the pH value resulted in a structural or organizational change in AuNPs.…”

Section: ■ Results and Discussionmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 99%

“…The purple color of liquid products is due to the AuNPs characteristics of surface plasmon resonance. , This implies that the AuNPs dispersed stably in aqueous solution products. It is also known that the peak optical absorption in AuNPs ranges from 510 to 550 nm in wavelength, and the spectral intensity depends on the number, shape, and dispersity of the particles. ,, …”

Section: Resultsmentioning

confidence: 99%

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Atmospheric-Pressure Pulsed Discharge Plasma in a Slug Flow Reactor System for the Synthesis of Gold Nanoparticles

et al. 2020

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Gold nanoparticle (AuNP) formation by applying pulsed discharge plasma in the slug flow reactor system was demonstrated. Experiments were carried out continuously at room temperature. The argon gas as a gas phase and the hydrogen tetrachloroaurate(III) tetra hydrate solution containing lysine as a liquid phase simultaneously flowed in the slug flow reactor system. The flow rates of the feed solution and argon gas were kept at 1.5 and 0.2 mL/min, respectively. To generate discharge plasma, the AC power supply with a bipolar pulsed output at 10 kV was applied. The purple color solution product was obtained, and the ultraviolet–visible (UV–vis) spectrophotometer showed that this possessed the absorption light from 510 to 550 nm associated with the existence of gold nanoparticles in each collected sample. Transmission electron microscopy (TEM) revealed that the lysine-capped AuNPs were produced in a spherical morphology and dispersed in aqueous solution products with a diameter of less than 20 nm.

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Theranostic nanocomplex of gold-decorated upconversion nanoparticles for optical imaging and temperature-controlled photothermal therapy

Cited by 18 publications

References 42 publications

Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

Nanocomposites based on lanthanide-doped upconversion nanoparticles: diverse designs and applications

Atmospheric-Pressure Pulsed Discharge Plasma in a Slug Flow Reactor System for the Synthesis of Gold Nanoparticles

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