Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

Abstract

Photothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.

Dual‐Effective Chronic Wounds Management System through a Monoglyceride Binary Blend Matrix Based Thermal‐Responsive Phase‐Transition Substrate

“…To prove the practical value of GG and GG-rGO-Ag, the diabetic model was successfully established by injection of alloxan [24,25] (Figures S40-S42, Supporting Information). The wound closure process was recorded and analyzed in detail (Figure 5a).…”

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

“…However, recent evidence indicates MBGs suitability in managing skin wounds as well. On this matter, the reported studies have been full of hopes and promise [ 17 ]; however, more research should be carried out to determine all the pros and cons in the way of extensive usage of MBGs in skin wound healing. For example, their optimal formulation and dosages, as well as final fate in injured sites, indeed deserve careful investigation in the future.…”

Intelligent Silk Fibroin Based Microneedle Dressing (i‐SMD)

“…Nonhealing wounds often lead to serious damage to the body such as severe bleeding and bacterial infections. [1][2][3][4][5] Thus, timely healing of skin wounds is needed. Wound secretion is a kind of compound secreted by damaged tissues during wound recovery.…”