Theranostic Carbon Dots with Innovative NIR-II Emission for in Vivo Renal-Excreted Optical Imaging and Photothermal Therapy

Li, Youbin; Bai, Gongxun; Zeng, Songjun; Hao, Jianhua

doi:10.1021/acsami.8b14877

Cited by 237 publications

(169 citation statements)

References 49 publications

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“…The ease of modification, low toxicity, and most importantly, outstanding FL properties make BCDs ideal drug delivery vehicles. Except transport drug molecules into cells, BCDs can also serve as bioimaging agents . In the past few years, many research groups have used a variety of raw materials to prepare a wide variety of BCDs for bioimaging.…”

Section: Applications Of Bcdsmentioning

confidence: 99%

Biomass‐Derived Carbon Dots and Their Applications

Meng

Bai

Wang

et al. 2019

Energy & Environ Materials

376

179

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Carbon dots (CDs) have received much attention due to their superior properties including water solubility, low toxicity, biocompatibility, small size, fluorescence, and ease of modification. The use of a more environmentally friendly method to prepare high‐quality CDs is still an urgent question waiting for solve. The use of renewable, inexpensive, and green biomass resources not only meets the urgent need for large‐scale synthesis biomass CDs (BCDs), but also promotes the development of sustainable applications. In this article, we summarize the representative methods for synthesizing BCDs in green and simple ways using biomass as a carbon source, including hydrothermal carbonization, and microwave, pyrolysis. The prepared BCDs have a uniform particle size distribution and a relatively high throughput, which provide a method to scale up industrial production. Moreover, the integration of specific optical properties, that is, tunable photoluminescence and up‐photoluminescence, has led to remarkable use in bioimaging, sensing, and drug delivery. But the current review is not particularly comprehensive for BCDs. Therefore, we now provide a review focusing on the synthesis, properties, and recent advances in BCDs in biosensing, bioimaging, optoelectronics, and catalytic applications.

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Section: Applications Of Bcdsmentioning

confidence: 99%

Biomass‐Derived Carbon Dots and Their Applications

Meng

Bai

Wang

et al. 2019

Energy & Environ Materials

376

179

View full text Add to dashboard Cite

show abstract

“…This blue supra-CDs exhibited a broad absorption peak in the NIR region which is responsible to the high photothermal conversion efficiency 52%) under 732 nm laser of 0.5 W cm −2 . Li et al [157] showed the CDs from the biomass-watermelon, which showed the NIR II imaging and photothermal conversion efficiency of 30.6% triggered by laser of 808 nm. It is well known that the d orbits of Cu(II) can split under the ligand field with specific geometry, generating higher degenerate e.g.…”

Section: Fluorescent Cds Conjugated With Photothermal Therapeutic (Ptmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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“…Not only photodynamic therapy, also photothermal therapy (PTT) has been proven to induce irreversible damage to many cancer cell types [96]. CDs can be used as potential photothermal agents since they can induce enormous temperature changes under irradiation [8].…”

Section: Carbon Dots As Photothermal Agentsmentioning

confidence: 99%

Advances in fluorescent carbon dots for biomedical applications

Koutsogiannis

Thomou

Stamatis

et al. 2020

Advances in Physics: X

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Carbon Dots are an emerging class of carbon-based nanoparticles, which since their discovery have attracted tremendous attention because of their exceptional fluorescent, chemical and mechanical properties as well as high photostability and biocompatibility. This unique combination of outstanding characteristics, together with the ease with which they can be synthesized, qualify carbon dots as highly promising materials for applications in electronics and biology, in particular, for biosensing, bioimaging, biotherapy and drug delivery. In this review, we present some of the most recent applications of carbon dots in biology and medicine, concentrating on their fluorescence properties, biocompatibility and efficiency; we also discuss how improvements could prompt their use in human studies. We illustrate how carbon dots, prepared through several facile and costeffective methods by either the bottom-up or the top-down route, can be used for imaging cells and bacteria and as sensing probes of metal cations. Moreover, we explain how their astonishing versatility has given rise to new biotherapy methods especially in the field of cancer theranostics.

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Theranostic Carbon Dots with Innovative NIR-II Emission for in Vivo Renal-Excreted Optical Imaging and Photothermal Therapy

Cited by 237 publications

References 49 publications

Biomass‐Derived Carbon Dots and Their Applications

Biomass‐Derived Carbon Dots and Their Applications

Recent advance of carbon dots in bio-related applications

Advances in fluorescent carbon dots for biomedical applications

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